Plasma proteomics analysis of patients with chronic spontaneous urticaria reveals significant associations with key disease characteristics but not with response to omalizumab treatment.

Autor: Ghazanfar MN; Department of Dermato-Venereology & Wound Healing Centre, Urticaria Center of Reference and Excellence (UCARE), Bispebjerg Hospital, Copenhagen, Denmark., Petrosius V; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Sørensen JA; Department of Dermato-Venereology & Wound Healing Centre, Urticaria Center of Reference and Excellence (UCARE), Bispebjerg Hospital, Copenhagen, Denmark., Zhang DG; Department of Dermato-Venereology & Wound Healing Centre, Urticaria Center of Reference and Excellence (UCARE), Bispebjerg Hospital, Copenhagen, Denmark., Ali Z; Department of Dermato-Venereology & Wound Healing Centre, Urticaria Center of Reference and Excellence (UCARE), Bispebjerg Hospital, Copenhagen, Denmark., Maurer M; Urticaria Center of Reference and Excellence (UCARE), Institute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany., Kocatürk E; Urticaria Center of Reference and Excellence (UCARE), Institute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany.; Department of Dermatology, Koç University School of Medicine, Istanbul, Turkey., Nielsen VW; Department of Dermato-Venereology & Wound Healing Centre, Urticaria Center of Reference and Excellence (UCARE), Bispebjerg Hospital, Copenhagen, Denmark., Savickas S; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Keller UAD; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Schoof EM; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Thomsen SF; Department of Dermato-Venereology & Wound Healing Centre, Urticaria Center of Reference and Excellence (UCARE), Bispebjerg Hospital, Copenhagen, Denmark.; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

Publikováno v: Allergy [Allergy] 2024 Sep; Vol. 79 (9), pp. 2547-2550. Date of Electronic Publication: 2024 May 26.

Assessing the Role of Trypsin in Quantitative Plasma and Single-Cell Proteomics toward Clinical Application.

Autor: Woessmann J; Department of Biotechnology and Biomedicine, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark.; Science for Life Laboratory, KTH─Royal Institute of Technology, SE-171 65 Solna, Sweden.; Department of Protein Science, KTH─Royal Institute of Technology, SE-106 91 Stockholm, Sweden., Petrosius V; Department of Biotechnology and Biomedicine, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark., Üresin N; The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, 2200 Copenhagen, Denmark., Kotol D; Science for Life Laboratory, KTH─Royal Institute of Technology, SE-171 65 Solna, Sweden.; Department of Protein Science, KTH─Royal Institute of Technology, SE-106 91 Stockholm, Sweden., Aragon-Fernandez P; Department of Biotechnology and Biomedicine, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark., Hober A; Science for Life Laboratory, KTH─Royal Institute of Technology, SE-171 65 Solna, Sweden.; Department of Protein Science, KTH─Royal Institute of Technology, SE-106 91 Stockholm, Sweden., Auf dem Keller U; Department of Biotechnology and Biomedicine, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark., Edfors F; Science for Life Laboratory, KTH─Royal Institute of Technology, SE-171 65 Solna, Sweden.; Department of Protein Science, KTH─Royal Institute of Technology, SE-106 91 Stockholm, Sweden., Schoof EM; Department of Biotechnology and Biomedicine, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark.

Publikováno v: Analytical chemistry [Anal Chem] 2023 Sep 12; Vol. 95 (36), pp. 13649-13658. Date of Electronic Publication: 2023 Aug 28.

DNA binding and RAD51 engagement by the BRCA2 C-terminus orchestrate DNA repair and replication fork preservation.

Autor: Kwon Y; Department of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Rösner H; Biotech Research and Innovation Centre, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200, Copenhagen N, Denmark., Zhao W; Department of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Selemenakis P; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA.; Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., He Z; Department of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Kawale AS; Department of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, 02129, USA., Katz JN; Department of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Rogers CM; Department of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Neal FE; Department of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Badamchi Shabestari A; Department of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Petrosius V; Biotech Research and Innovation Centre, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200, Copenhagen N, Denmark., Singh AK; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT, USA.; GentiBio Inc., 150 Cambridgepark Dr, Cambridge, MA, 02140, USA., Joel MZ; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT, USA.; Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Lu L; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT, USA., Holloway SP; Department of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Burma S; Department of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.; Department of Neurosurgery, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Mukherjee B; Department of Neurosurgery, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Hromas R; Department of Medicine, University of Texas Health at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, USA., Mazin A; Department of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Wiese C; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA. claudia.wiese@colostate.edu., Sørensen CS; Biotech Research and Innovation Centre, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200, Copenhagen N, Denmark. claus.storgaard@bric.ku.dk., Sung P; Department of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA. sungp@uthscsa.edu.

Publikováno v: Nature communications [Nat Commun] 2023 Jan 26; Vol. 14 (1), pp. 432. Date of Electronic Publication: 2023 Jan 26.

Temporal phosphoproteomics reveals WEE1-dependent control of 53BP1 pathway.

Autor: Petrosius V; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark., Benada J; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark., Nielsen O; Cell Cycle and Genome Stability Group, Department of Molecular Biology, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen K, Denmark., Schoof EM; Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads 224, 2800 Kgs. Lyngby, Denmark., Sørensen CS; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark.

Publikováno v: IScience [iScience] 2022 Dec 13; Vol. 26 (1), pp. 105806. Date of Electronic Publication: 2022 Dec 13 (Print Publication: 2023).

WEE1 kinase protects the stability of stalled DNA replication forks by limiting CDK2 activity.

Autor: Elbæk CR; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaløesvej 5, Copenhagen N 2200, Denmark; Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads, Kongens Lyngby 2800, Denmark., Petrosius V; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaløesvej 5, Copenhagen N 2200, Denmark., Benada J; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaløesvej 5, Copenhagen N 2200, Denmark., Erichsen L; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaløesvej 5, Copenhagen N 2200, Denmark., Damgaard RB; Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads, Kongens Lyngby 2800, Denmark., Sørensen CS; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaløesvej 5, Copenhagen N 2200, Denmark. Electronic address: claus.storgaard@bric.ku.dk.

Publikováno v: Cell reports [Cell Rep] 2022 Jan 18; Vol. 38 (3), pp. 110261.