Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Petros Tyrakis"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8630 (2024)
Alzheimer’s disease (AD), a progressive neurodegenerative disorder, manifests through dysregulation of brain function and subsequent loss of bodily control, attributed to β-amyloid plaque deposition and TAU protein hyperphosphorylation and aggrega
Externí odkaz:
https://doaj.org/article/6be3fae4a8fc40a1943782db2386dc65
Autor:
Iosifina P. Foskolou, Pedro P Cunha, Eleanor Minogue, Benoit P Nicolet, Aurelie Guislain, Christian Jorgensen, Nordin D Zandhuis, Laura Barbieri, David Bargiela, Demitris Nathanael, Petros Tyrakis, Asis Palazon, Monika C Wolkers, Randall S Johnson
SUMMARY2-hydroxyglutarate (2HG) is a by-product of the TCA cycle, and is readily detected in the tissues of healthy individuals. 2HG is found in two enantiomeric forms: S-2HG and R-2HG. Here, we investigate the differential roles of these two enantio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3171c013fcf504e83cd81bb30e0da657
https://doi.org/10.1101/2022.08.18.504372
https://doi.org/10.1101/2022.08.18.504372
Autor:
João A, Ribeiro, Alexander, Hammer, Gerardo A, Libreros-Zúñiga, Sair M, Chavez-Pacheco, Petros, Tyrakis, Gabriel S, de Oliveira, Timothy, Kirkman, Jamal, El Bakali, Silvana A, Rocco, Mauricio L, Sforça, Roberto, Parise-Filho, Anthony G, Coyne, Tom L, Blundell, Chris, Abell, Marcio V B, Dias
Publikováno v:
ACS infectious diseases. 6(8)
Dihydrofolate reductase (DHFR), a key enzyme involved in folate metabolism, is a widely explored target in the treatment of cancer, immune diseases, bacteria, and protozoa infections. Although several antifolates have proved successful in the treatme
Autor:
Colin E Evans, Cristina Branco-Price, Alice Prodger, Asis Palazon, Petros Tyrakis, Helene Rundqvist, Par-Ola Bendahl, Mattias Belting, Randall S Johnson
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 35
Introduction: Mechanisms that regulate the positive association between thrombosis and metastasis are incompletely understood. It was hypothesised that thrombus formation stimulates a hypoxic response, which in turn promotes extravasation. The primar