Zobrazeno 1 - 10
of 205
pro vyhledávání: '"Petros C. Karakousis"'
Autor:
Leon L. Hsieh, Monika Looney, Alexis Figueroa, Guido Massaccesi, Georgia Stavrakis, Eduardo U. Anaya, Franco R. D'Alessio, Alvaro A. Ordonez, Andrew S. Pekosz, Victor R. DeFilippis, Petros C. Karakousis, Andrew H. Karaba, Andrea L. Cox
Publikováno v:
mBio, Vol 15, Iss 10 (2024)
ABSTRACT The pathogenesis of COVID-19 is associated with a hyperinflammatory immune response. Monocytes and macrophages play a central role in this hyperinflammatory response to SARS-CoV-2. NLRP3 inflammasome activation has been observed in monocytes
Externí odkaz:
https://doaj.org/article/aa0e19b78c824561aa71c9c28ac4ee3b
Autor:
James Tristan Gordy, Yinan Hui, Courtney Schill, Tianyin Wang, Fengyixin Chen, Kaitlyn Fessler, Jacob Meza, Yangchen Li, Alannah D. Taylor, Rowan E. Bates, Petros C. Karakousis, Andrew Pekosz, Jaiprasath Sachithanandham, Maggie Li, Styliani Karanika, Richard B. Markham
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundPrevious studies have demonstrated enhanced efficacy of vaccine formulations that incorporate the chemokine macrophage inflammatory protein 3α (MIP-3α) to direct vaccine antigens to immature dendritic cells. To address the reduction in va
Externí odkaz:
https://doaj.org/article/708db69f8a054d40b2e5f6c712033389
Autor:
Vignesh Chidambaram, Amudha Kumar, Bhavna Seth, Dinesh Voruganti, Subhi J. Al'Aref, Panagis Galiatsatos, Petros C. Karakousis, Jawahar L. Mehta
Publikováno v:
American Journal of Preventive Cardiology, Vol 13, Iss , Pp 100409- (2023)
Therapeutic Area: ASCVD/CVD Risk Factors Background: Host cell-membrane cholesterol, an important player in viral infections, is in constant interaction with serum lipids, such as high-density lipoprotein cholesterol (HDL-C) and low-density lipoprote
Externí odkaz:
https://doaj.org/article/c677477cd6884aa2b96b1fe8d304c157
Autor:
William M. Matern, Harley T. Harris, Carina Danchik, Marissa McDonald, Gopi Patel, Aashish Srivastava, Thomas R. Ioerger, Joel S. Bader, Petros C. Karakousis
Publikováno v:
Microorganisms, Vol 11, Iss 9, p 2269 (2023)
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), poses a global health challenge and is responsible for over a million deaths each year. Current treatment is lengthy and complex, and new, abbreviated regimens are urgently n
Externí odkaz:
https://doaj.org/article/b37aec3ccc9845ddb8d54ddb9956d983
Autor:
James T. Gordy, Avinaash K. Sandhu, Kaitlyn Fessler, Kun Luo, Aakanksha R. Kapoor, Samuel K. Ayeh, Yinan Hui, Courtney Schill, Fengyixin Chen, Tianyin Wang, Styliani Karanika, Joel C. Sunshine, Petros C. Karakousis, Richard B. Markham
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
IntroductionDNA vaccines containing a fusion of the gene encoding chemokine MIP-3α (CCL20), the ligand for CCR6 on immature dendritic cells (DCs), to melanoma-associated antigen genes have enhanced anti-tumor immunity and efficacy compared to those
Externí odkaz:
https://doaj.org/article/f580847271df43f3ba7a30b33b0a8791
The Global Health Security Index is not predictive of vaccine rollout responses among OECD countries
Autor:
Banda A. Khalifa, Enoch J. Abbey, Samuel K. Ayeh, Hasiya E. Yusuf, Richard D Nudotor, Ngozi Osuji, Samiha Khan, Esosa Nosakhare, Modupe O. Oduwole, Emmanuella L. Salia, Oluwatobi Lasisi, Petros C. Karakousis
Publikováno v:
International Journal of Infectious Diseases, Vol 113, Iss , Pp 7-11 (2021)
Objective: This study sought to evaluate the utility of the Global Health Security (GHS) index in predicting the launch of COVID-19 vaccine rollout by Organization for Economic Cooperation and Development (OECD) member countries.Methods: Country-leve
Externí odkaz:
https://doaj.org/article/f344d3e09799453f97620622a6eed69c
Autor:
Styliani Karanika, James T. Gordy, Pranita Neupane, Theodoros Karantanos, Jennie Ruelas Castillo, Darla Quijada, Kaitlyn Comstock, Avinaash K. Sandhu, Aakanksha R. Kapoor, Yinan Hui, Samuel K. Ayeh, Rokeya Tasneen, Stefanie Krug, Carina Danchik, Tianyin Wang, Courtney Schill, Richard B. Markham, Petros C. Karakousis
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Lengthy tuberculosis (TB) treatment is required to overcome the ability of a subpopulation of persistent Mycobacterium tuberculosis (Mtb) to remain in a non-replicating, antibiotic-tolerant state characterized by metabolic remodeling, including induc
Externí odkaz:
https://doaj.org/article/9e6a0ab5a6a54babb18f999d3a442d6d
Autor:
Vignesh Chidambaram, Jennie Ruelas Castillo, Amudha Kumar, Justin Wei, Siqing Wang, Marie Gilbert Majella, Akshay Gupte, Jann-Yuan Wang, Petros C. Karakousis
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Tuberculosis (TB) and atherosclerotic cardiovascular disease (ASCVD) have a close epidemiological and pathogenetic overlap. Thus, it becomes essential to understand the relationship between ASCVD and TB outcomes. From our retrospective cohor
Externí odkaz:
https://doaj.org/article/0d8f4950a93b4efbb6c8e077efd9ebd3
Autor:
Vignesh Chidambaram, Amudha Kumar, Marie Gilbert Majella, Bhavna Seth, Ranjith Kumar Sivakumar, Dinesh Voruganti, Mahesh Bavineni, Ahmad Baghal, Kim Gates, Annu Kumari, Subhi J. Al'Aref, Panagis Galiatsatos, Petros C. Karakousis, Jawahar L. Mehta
Publikováno v:
EBioMedicine, Vol 82, Iss , Pp 104166- (2022)
Summary: Background: Host cell-membrane cholesterol, an important player in viral infections, is in constant interaction with serum high-density lipoprotein-cholesterol (HDL-C) and low-density lipoprotein-cholesterol (LDL-C). Low serum lipid levels d
Externí odkaz:
https://doaj.org/article/b745c599600043fab5254a80253aba69
Publikováno v:
BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-9 (2021)
Abstract COVID-19 is a novel disease caused by SARS-CoV-2. During the global vaccination rollout, it is vital to thoroughly understand the modes of transmission of the virus in order to prevent further spread of variants and ultimately to end the pan
Externí odkaz:
https://doaj.org/article/5b4e66181a204d41812d618e2fedf1ea