Zobrazeno 1 - 10
of 205
pro vyhledávání: '"Petros C Karakousis"'
Autor:
Samuel K Ayeh, Enoch J Abbey, Banda A A Khalifa, Richard D Nudotor, Albert Danso Osei, Vignesh Chidambaram, Ngozi Osuji, Samiha Khan, Emmanuella L Salia, Modupe O Oduwole, Hasiya E Yusuf, Oluwatobi Lasisi, Esosa Nosakhare, Petros C Karakousis
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0256899 (2021)
BackgroundThere is an urgent need for novel therapeutic strategies for reversing COVID-19-related lung inflammation. Recent evidence has demonstrated that the cholesterol-lowering agents, statins, are associated with reduced mortality in patients wit
Externí odkaz:
https://doaj.org/article/088dd1bd9d78445cb4f07f17f272c332
Autor:
Vignesh Chidambaram, Nyan Lynn Tun, Waqas Z Haque, Marie Gilbert Majella, Ranjith Kumar Sivakumar, Amudha Kumar, Angela Ting-Wei Hsu, Izza A Ishak, Aqsha A Nur, Samuel K Ayeh, Emmanuella L Salia, Ahsan Zil-E-Ali, Muhammad A Saeed, Ayu P B Sarena, Bhavna Seth, Muzzammil Ahmadzada, Eman F Haque, Pranita Neupane, Kuang-Heng Wang, Tzu-Miao Pu, Syed M H Ali, Muhammad A Arshad, Lin Wang, Sheriza Baksh, Petros C Karakousis, Panagis Galiatsatos
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0241541 (2020)
BackgroundUnderstanding the factors associated with disease severity and mortality in Coronavirus disease (COVID-19) is imperative to effectively triage patients. We performed a systematic review to determine the demographic, clinical, laboratory and
Externí odkaz:
https://doaj.org/article/e6cf0132187e48dab7d3740327b84782
Autor:
Enoch J Abbey, Banda A A Khalifa, Modupe O Oduwole, Samuel K Ayeh, Richard D Nudotor, Emmanuella L Salia, Oluwatobi Lasisi, Seth Bennett, Hasiya E Yusuf, Allison L Agwu, Petros C Karakousis
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0239398 (2020)
The ongoing COVID-19 pandemic has devastated many countries with ripple effects felt in various sectors of the global economy. In November 2019, the Global Health Security (GHS) Index was released as the first detailed assessment and benchmarking of
Externí odkaz:
https://doaj.org/article/1b251881944641379faa07e5936c89da
Autor:
Leon L. Hsieh, Monika Looney, Alexis Figueroa, Guido Massaccesi, Georgia Stavrakis, Eduardo U. Anaya, Franco R. D'Alessio, Alvaro A. Ordonez, Andrew S. Pekosz, Victor R. DeFilippis, Petros C. Karakousis, Andrew H. Karaba, Andrea L. Cox
Publikováno v:
mBio, Vol 15, Iss 10 (2024)
ABSTRACT The pathogenesis of COVID-19 is associated with a hyperinflammatory immune response. Monocytes and macrophages play a central role in this hyperinflammatory response to SARS-CoV-2. NLRP3 inflammasome activation has been observed in monocytes
Externí odkaz:
https://doaj.org/article/aa0e19b78c824561aa71c9c28ac4ee3b
Autor:
Lalitha Srinivasan, Serdar A Gurses, Benjamin E Hurley, Jessica L Miller, Petros C Karakousis, Volker Briken
Publikováno v:
PLoS Pathogens, Vol 12, Iss 5, p e1005652 (2016)
The interaction of Mycobacterium tuberculosis (Mtb) with host cell death signaling pathways is characterized by an initial anti-apoptotic phase followed by a pro-necrotic phase to allow for host cell exit of the bacteria. The bacterial modulators reg
Externí odkaz:
https://doaj.org/article/2c476a43455d48089ba8adeb807e9b93
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147192 (2016)
Co-infection with Mycobacterium tuberculosis accelerates progression from HIV to AIDS. Our previous studies showed that M. tuberculosis complex, unlike M. smegmatis, enhances TLR2-dependent susceptibility of CD4+ T cells to HIV. The M. tuberculosis c
Externí odkaz:
https://doaj.org/article/1a2c1a0258784da4bd90a4d5281f4917
Autor:
Selvakumar Subbian, Liana Tsenova, Mi-Jeong Kim, Helen C Wainwright, Annalie Visser, Nirmalya Bandyopadhyay, Joel S Bader, Petros C Karakousis, Gabriele B Murrmann, Linda-Gail Bekker, David G Russell, Gilla Kaplan
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132249 (2015)
The formation and maintenance of granulomas is central to the host response to Mycobacterium tuberculosis (Mtb) infection. It is widely accepted that the lungs of patients with tuberculosis (TB) usually contain multiple infection foci, and that the g
Externí odkaz:
https://doaj.org/article/16167bfc738a42f19540f6b99a0839c0
Autor:
Ciaran Skerry, Supriya Pokkali, Michael Pinn, Nicholas A Be, Jamie Harper, Petros C Karakousis, Sanjay K Jain
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66310 (2013)
We have previously identified Mycobacterium tuberculosis PknD to be an important virulence factor required for the pathogenesis of central nervous system (CNS) tuberculosis (TB). Specifically, PknD mediates bacillary invasion of the blood-brain barri
Externí odkaz:
https://doaj.org/article/de2334973bd64c369211bcd0f0f19958
Autor:
Seema M Thayil, Ya-Chi Ho, Robert C Bollinger, Joel N Blankson, Robert F Siliciano, Petros C Karakousis, Kathleen R Page
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41093 (2012)
Among HIV-infected individuals, co-infection with Mycobacterium tuberculosis is associated with faster progression to AIDS. We investigated the hypothesis that M. bovis BCG and M. tuberculosis (Mtb complex) could enhance susceptibility of CD4+ cells
Externí odkaz:
https://doaj.org/article/2c51c965ecec4440a8a4c75a3d51ad39
Autor:
Bing-Shao Chia, Fedora Lanzas, Dalin Rifat, Aubrey Herrera, Elizabeth Y Kim, Christine Sailer, Edith Torres-Chavolla, Purvaja Narayanaswamy, Viktor Einarsson, Jaime Bravo, Juan M Pascale, Thomas R Ioerger, James C Sacchettini, Petros C Karakousis
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40456 (2012)
The frequency of individual genetic mutations conferring drug resistance (DR) to Mycobacterium tuberculosis has not been studied previously in Central America, the place of origin of many immigrants to the United States. The current gold standard for
Externí odkaz:
https://doaj.org/article/66164b15925a4c009ca55f00ee068d78