GRK2-mediated AKT activation controls cell cycle progression and G2 checkpoint in a p53-dependent manner

Autor: Verónica Rivas, Teresa González-Muñoz, Ángela Albitre, Vanesa Lafarga, Cristina Delgado-Arévalo, Federico Mayor, Petronila Penela

Publikováno v: Cell Death Discovery, Vol 10, Iss 1, Pp 1-19 (2024)

Abstract Cell cycle checkpoints, activated by stressful events, halt the cell cycle progression, and prevent the transmission of damaged DNA. These checkpoints prompt cell repair but also trigger cell death if damage persists. Decision-making between

Externí odkaz: https://doaj.org/article/f474f24de365466aa2e172883990a2eb

Degradation of GRK2 and AKT is an early and detrimental event in myocardial ischemia/reperfusionResearch in context

Autor: Petronila Penela, Javier Inserte, Paula Ramos, Antonio Rodriguez-Sinovas, David Garcia-Dorado, Federico Mayor, Jr

Publikováno v: EBioMedicine, Vol 48, Iss , Pp 605-618 (2019)

Background: Identification of signaling pathways altered at early stages after cardiac ischemia/reperfusion (I/R) is crucial to develop timely therapies aimed at reducing I/R injury. The expression of G protein-coupled receptor kinase 2 (GRK2), a key

Externí odkaz: https://doaj.org/article/857a76c86336481095934286f38a0946

G Protein-coupled Receptor Kinase 2 (GRK2) Promotes Breast Tumorigenesis Through a HDAC6-Pin1 Axis

Autor: Laura Nogués, Clara Reglero, Verónica Rivas, Alicia Salcedo, Vanesa Lafarga, Maria Neves, Paula Ramos, Marta Mendiola, Alberto Berjón, Kostas Stamatakis, Xiao Zhen Zhou, Kun Ping Lu, David Hardisson, Federico Mayor Jr., Petronila Penela

Publikováno v: EBioMedicine, Vol 13, Iss C, Pp 132-145 (2016)

In addition to oncogenic drivers, signaling nodes can critically modulate cancer-related cellular networks to strength tumor hallmarks. We identify G-protein-coupled receptor kinase 2 (GRK2) as a relevant player in breast cancer. GRK2 is up-regulated

Externí odkaz: https://doaj.org/article/b1dfca60da144d5db201e71b0938f759

The CXCL12/CXCR4/ACKR3 Axis in the Tumor Microenvironment: Signaling, Crosstalk, and Therapeutic Targeting

Autor: Géraldine Schlecht-Louf, Marco Siderius, Petronila Penela, Jelle van den Bor, Martine J. Smit, Françoise Bachelerie, Federico Mayor, Maria Neves

Publikováno v: Annual Review of Pharmacology and Toxicology, 61, 541-563. Annual Reviews Inc.
Smit, M J, Schlecht-Louf, G, Neves, M, Van Den Bor, J, Penela, P, Siderius, M, Bachelerie, F & Mayor, F 2021, ' The CXCL12/CXCR4/ACKR3 Axis in the Tumor Microenvironment: Signaling, Crosstalk, and Therapeutic Targeting ', Annual Review of Pharmacology and Toxicology, vol. 61, pp. 541-563 . https://doi.org/10.1146/annurev-pharmtox-010919-023340
Annual Review of Pharmacology and Toxicology

Elevated expression of the chemokine receptors CXCR4 and ACKR3 and of their cognate ligand CXCL12 is detected in a wide range of tumors and the tumor microenvironment (TME). Yet, the molecular mechanisms by which the CXCL12/CXCR4/ACKR3 axis contribut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e339715ecc2f768c0a8a1e5426253c2
https://doi.org/10.1146/annurev-pharmtox-010919-023340

Mdm2-Mediated Downmodulation of GRK2 Restricts Centrosome Separation for Proper Chromosome Congression

Autor: Petronila Penela, Belén Ortiz del Castillo, Verónica Rivas, Federico Mayor, Clara Reglero

Publikováno v: Cells
Volume 10
Issue 4
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cells, Vol 10, Iss 729, p 729 (2021)

The timing of centrosome separation and the distance moved apart influence the formation of the bipolar spindle, affecting chromosome stability. Epidermal growth factor receptor (EGFR) signaling induces early centrosome separation through downstream

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783f362abb6efb0aa12c759dd6c413e9