Extract from Armoracia rusticana and Its Flavonoid Components Protect Human Lymphocytes against Oxidative Damage Induced by Hydrogen Peroxide

Autor: Michala Gafrikova, Eliska Galova, Andrea Sevcovicova, Petronela Imreova, Pavel Mucaji, Eva Miadokova

Publikováno v: Molecules, Vol 19, Iss 3, Pp 3160-3172 (2014)

DNA damage prevention is an important mechanism involved in cancer prevention by dietary compounds. Armoracia rusticana is cultivated mainly for its roots that are used in the human diet as a pungent spice. The roots represent rich sources of biologi

Externí odkaz: https://doaj.org/article/8360f5465d9040c99c7affd0fcd4d709

Hyperforin Exhibits Antigenotoxic Activity on Human and Bacterial Cells

Autor: Katarína Kozics, Kristina Bodnarova, Ivan Chalupa, Jana Feruszová, Petronela Imreova, Stanislav Kyzek, Pavel Mučaji, Andrea Sevcovicova, Martina Zduriencikova, Eva Miadoková, Eliška Gálová

Publikováno v: Molecules; Volume 22; Issue 1; Pages: 167
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules, Vol 22, Iss 1, p 167 (2017)

Hyperforin (HF), a substance that accumulates in the leaves and flowers of Hypericum perforatum L. (St. John’s wort), consists of a phloroglucinol skeleton with lipophilic isoprene chains. HF exhibits several medicinal properties and is mainly used

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c46d007ae2836762eaf88017327982ab

Photoactivated hypericin is not genotoxic

Autor: Ivan Chalupa, Eliška Gálová, Jana Feruszová, Eva Miadoková, Stanislav Kyzek, Andrea Sevcovicova, Petronela Imreova, Kristina Bodnarova

Publikováno v: General physiology and biophysics. 35(2)

The study was designed to test the potential photogenotoxicity of hypericin (HYP) at three different levels: primary DNA damages, gene mutations and chromosome aberrations. Primary genetic changes were detected using the comet assay. The potential mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed760e76d096f6f58ed6d2217b94f437
https://pubmed.ncbi.nlm.nih.gov/26891274

DNA-protective activities of hyperforin and aristoforin

Autor: Dusan Loderer, Eva Miadoková, Mária Kožurková, Eliška Gálová, Peter Fedoročko, Andrea Sevcovicova, Jana Plsikova, Petronela Imreova, Martina Šemeláková

Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA. 29(3)

The aim of this study was to explain the molecular mechanisms of action of hyperforin, a phluoroglucinol derivative found in Hypericum perforatum L. and its more stable derivative aristoforin. DNA-topology assay revealed partial DNA-protective activi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1ed9098f5fcc2b3d9e52e5496e1cc9e
https://pubmed.ncbi.nlm.nih.gov/25678043

Mechanisms of emodin bioprotectivity

Autor: Kristina Bodnarova, Eva Miadoková, Petronela Imreova, Andrea Sevcovicova, Dusan Loderer, Eliška Gálová

Publikováno v: Toxicology Letters. 229:S83

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d90034a0bc006eaddde067a3e602fb28
https://doi.org/10.1016/j.toxlet.2014.06.314