Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Petro Borysko"'
Autor:
Vadym V. Levterov, Yaroslav Panasiuk, Kateryna Sahun, Oleksandr Stashkevych, Valentyn Badlo, Oleh Shablykin, Iryna Sadkova, Lina Bortnichuk, Oleksii Klymenko-Ulianov, Yuliia Holota, Leonid Lachmann, Petro Borysko, Kateryna Horbatok, Iryna Bodenchuk, Yuliia Bas, Dmytro Dudenko, Pavel K. Mykhailiuk
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract The phenyl ring is a basic structural element in chemistry. Here, we show the design, synthesis, and validation of its new saturated bioisostere with improved physicochemical properties − 2-oxabicyclo[2.2.2]octane. The design of the struct
Externí odkaz:
https://doaj.org/article/40ae1c7eff7f48309d4252061fceaf57
Autor:
Mikhail Krasavin, Stanislav Kalinin, Sergey Zozulya, Anastasia Griniukova, Petro Borysko, Andrea Angeli, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 165-171 (2020)
Testing of an expanded, 800-compound set of analogues of the earlier described Strecker-type α-aminonitriles (selected from publicly available Enamine Ltd. Screening Collection) in thermal shift assay against bovine carbonic anhydrase (bCA) led to f
Externí odkaz:
https://doaj.org/article/e3b860d34fb7405fbc2cfb24b09d2294
Autor:
Mikhail Krasavin, Stanislav Kalinin, Sergey Zozulya, Anastasiia Gryniukova, Petro Borysko, Andrea Angeli, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 306-310 (2020)
The differential scanning fluorimetry (DSF) screening of 5.692 fragments in combination with benzenesulfonamide (BSA) against bovine carbonic anhydrase (bCA) delivered >100 hits that either caused, on their own, a significant thermal shift (ΔTm, °C
Externí odkaz:
https://doaj.org/article/fc10cfcdab0649f8818c3aee44de95e6
Autor:
Franca-Maria Klingler, Marcus Gastreich, Oleksandr O. Grygorenko, Olena Savych, Petro Borysko, Anastasia Griniukova, Kateryna E. Gubina, Christian Lemmen, Yurii S. Moroz
Publikováno v:
Molecules, Vol 24, Iss 17, p 3096 (2019)
We introduce SAR by Space, a concept to drastically accelerate structure-activity relationship (SAR) elucidation by synthesizing neighboring compounds that originate from vast chemical spaces. The space navigation is accomplished within minutes on af
Externí odkaz:
https://doaj.org/article/f9fd1d3cde3e4c9ca8fe4a49155cb0cc
Autor:
Roman V. Rodik, Sergiy O. Cherenok, Viktoriia Y. Postupalenko, Sule Oncul, Vladyslava Brusianska, Petro Borysko, Vitaly I. Kalchenko, Yves Mely, Andrey S. Klymchenko
Publikováno v:
Journal of Colloid and Interface Science. 624:270-278
Shape-persistent macrocycles enable superior control on molecular self-assembly, allowing the preparation of well-defined nanostructures with new functions. Here, we report on anionic amphiphilic calixarenes of conic shape and their self-assembly beh
Autor:
Janis Müller, Raphael Klein, Olga Tarkhanova, Anastasiia Gryniukova, Petro Borysko, Stefan Merkl, Moritz Ruf, Alexander Neumann, Marcus Gastreich, Yurii S. Moroz, Gerhard Klebe, Serghei Glinca
Publikováno v:
Journal of Medicinal Chemistry. 65:15663-15678
Fragment-based drug discovery (FBDD) has successfully led to approved therapeutics for challenging and "undruggable" targets. In the context of FBDD, we introduce a novel, multidisciplinary method to identify active molecules from purchasable chemica
Autor:
Halyna Kuznietsova, Petro Borysko, Alexander Rudnichenko, Dmytro L. Titikaiev, Serhii I. Sirobaba, Maksym V. Stambirskyi, Yurii V. Dmytriv, Iryna Pishel, Pavel K. Mykhailiuk, Tetiana Kostiuk
Publikováno v:
The Journal of Organic Chemistry. 86:12783-12801
A general practical approach to hetero(aromatic) and aliphatic P(O)Me2-substituted derivatives is elaborated. The key synthetic step was a [Pd]-mediated C-P coupling of (hetero)aryl bromides/iodides with HP(O)Me2. The P(O)Me2 substituent was shown to
Autor:
Sergey Holovach, Kostiantyn P. Melnykov, Artem Skreminskiy, Maksym Herasymchuk, Olha Tavlui, Danylo Aloshyn, Petro Borysko, Alexander B. Rozhenko, Sergey V. Ryabukhin, Dmitriy M. Volochnyuk, Oleksandr O. Grygorenko
Publikováno v:
Chemistry – A European Journal. 28
Autor:
Sergey Holovach, Kostiantyn P. Melnykov, Artem Skreminskiy, Maksym Herasymchuk, Olha Tavlui, Danylo Aloshyn, Petro Borysko, Alexander B. Rozhenko, Sergey V. Ryabukhin, Dmitriy M. Volochnyuk, Oleksandr O. Grygorenko
Publikováno v:
Chemistry – A European Journal. 28
Physico-chemical properties important to drug discovery (pK
Autor:
Igor V. Komarov, Ganna Tolstanova, Halyna Kuznietsova, Natalia Dziubenko, Petro I. Yanchuk, Lydia Y. Shtanova, Stanislav P. Veselsky, Liudmyla V. Garmanchuk, Nataliia Khranovska, Oleksandr Gorbach, Taisa Dovbynchuk, Petro Borysko, Oleg Babii, Tim Schober, Anne S. Ulrich, Sergii Afonin
Publikováno v:
Journal of Photochemistry and Photobiology B: Biology, 233, Art.-Nr.: 112479
An in vivo study of a photoswitchable cytotoxic peptide LMB040 has been undertaken on a chemically induced hepatocellular carcinoma model in immunocompetent rats. We analysed the pharmacokinetic profile of the less toxic photoform (“ring-closed”
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26099e5b5127a60a841d73a7119aec51