Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Petro, Halkowycz"'
Autor:
Ron de Jong, Takashi Satou, Bheema Paraselli, Charles Grimshaw, Yoshikazu Ohta, Mika Teratani, Toshiyuki Nomura, Seigo Ishino, BiChing Sang, Petro Halkowycz, Bumsup Lee, Robyn Fabrey, Sarah Elliott, Lilly Zhang, Takashi Hoshino, Deepika Balakrishna, Jennifer Matuszkiewicz, Lihong Shi, Pamela Farrell
PDF file - 56 KB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d578afa59c63d95d6d60d9fb9d264df
https://doi.org/10.1158/1535-7163.22498837.v1
https://doi.org/10.1158/1535-7163.22498837.v1
Autor:
Ron de Jong, Takashi Satou, Bheema Paraselli, Charles Grimshaw, Yoshikazu Ohta, Mika Teratani, Toshiyuki Nomura, Seigo Ishino, BiChing Sang, Petro Halkowycz, Bumsup Lee, Robyn Fabrey, Sarah Elliott, Lilly Zhang, Takashi Hoshino, Deepika Balakrishna, Jennifer Matuszkiewicz, Lihong Shi, Pamela Farrell
PDF file - 3 MB, Quantitative cellular target profiling of TAK-901 using affinity chromatography.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c76153b0135413183ebb9ffa88719414
https://doi.org/10.1158/1535-7163.22498843
https://doi.org/10.1158/1535-7163.22498843
Autor:
Paul Tanis, Urmi Banerjee, Ron de Jong, Charles E. Grimshaw, Mark Sabat, Chris Proffitt, Walter Keung, Petro Halkowycz, Kim Peacock, Jacques Ermolieff
Publikováno v:
SLAS Discovery. 26:676-683
Two different signaling pathways lead to the activation of the transcription factor NF-κB, initiating distinct biological responses: The canonical NF-κB pathway activation has been implicated in host immunity and inflammatory responses, whereas the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::461b487527afd747e2f0032556040ba0
https://doi.org/10.1177/2472555220964450
https://doi.org/10.1177/2472555220964450
Autor:
Simone V, Bigi-Botterill, Anthony, Ivetac, Erica L, Bradshaw, Derek, Cole, Douglas R, Dougan, Jacques, Ermolieff, Petro, Halkowycz, Ben, Johnson, Christopher, McBride, Jason, Pickens, Mark, Sabat, Steven, Swann
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(17)
Apoptosis Signal-Regulating Kinase-1 (ASK1) is a known member of the Mitogen-Activated Protein Kinase Kinase Kinase (MAP3K) family and upon stimulation will activate the p38- and JNK-pathways leading to cardiac apoptosis, fibrosis, and hypertrophy. U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e9508fc04218099085008152ac9ef4b6
https://pubmed.ncbi.nlm.nih.gov/32738982
https://pubmed.ncbi.nlm.nih.gov/32738982
Autor:
Loui Madakamutil, Ewan Taylor, Phong H. Vu, Mark Sabat, Deepika Balakrishna, Beverly Knight, Haixia Wang, Corey Wyrick, Mark S. Hixon, Nicholas Scorah, Christopher Ronald Smith, Donavon McConn, Petro Halkowycz, Douglas R. Dougan, J. David Lawson, Jacques Ermolieff
Publikováno v:
Journal of Medicinal Chemistry. 64:16318-16318
This publication details the successful use of FBDD (fragment-based drug discovery) principles in the invention of a novel covalent Bruton's tyrosine kinase inhibitor, which ultimately became the Takeda Pharmaceuticals clinical candidate TAK-020. Des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77e890954972cb077d4fa384cc9189ca
https://doi.org/10.1021/acs.jmedchem.1c01685
https://doi.org/10.1021/acs.jmedchem.1c01685
Autor:
Petro Halkowycz, Zacharia Cheruvallath, Mark Sabat, Bumsup Lee, David J. Hosfield, Andrew John Jennings, Haixia Wang, Mingnam Tang, Stephen L. Gwaltney, Yiqin Wu, Charles E. Grimshaw
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:2678-2682
Guided by co-crystal structural information obtained from a different series we were exploring, a scaffold morphing and SBDD approach led to the discovery of the 1,4-disubstituted indazole series as a novel class of GKAs that potently activate GK in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ed0d84b42b1111c1cc3b8ded9c30c17
https://doi.org/10.1016/j.bmcl.2017.04.041
https://doi.org/10.1016/j.bmcl.2017.04.041
Autor:
Haixia Wang, Marion Lanier, Jacques Ermolieff, Jason Pickens, Tony Gibson, Steve Swann, Joanne Miura, Anthony Ivetac, Erica L. Bradshaw-Pierce, Mark Sabat, Petro Halkowycz, Tyhonas John, Douglas R. Dougan, Derek C. Cole, Simone V. Bigi, Evan Nunez, Xiaolun Wang, Alison Chambers, Zacharia Cheruvallath, Aki Hirokawa
Publikováno v:
ACS Medicinal Chemistry Letters. 8:316-320
Apoptosis signal-regulating kinase 1 (ASK1/MAP3K) is a mitogen-activated protein kinase family member shown to contribute to acute ischemia/reperfusion injury. Using structure-based drug design, deconstruction, and reoptimization of a known ASK1 inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b83736b9abec7698eec902596de03c
https://doi.org/10.1021/acsmedchemlett.6b00481
https://doi.org/10.1021/acsmedchemlett.6b00481
Autor:
Petro Halkowycz, Douglas R. Dougan, Simone V. Bigi-Botterill, Derek C. Cole, Ben Johnson, Erica L. Bradshaw, Christopher McBride, Mark Sabat, Steven Swann, Anthony Ivetac, Jacques Ermolieff, Jason Pickens
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:127405
Apoptosis Signal-Regulating Kinase-1 (ASK1) is a known member of the Mitogen-Activated Protein Kinase Kinase Kinase (MAP3K) family and upon stimulation will activate the p38- and JNK-pathways leading to cardiac apoptosis, fibrosis, and hypertrophy. U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25da11a914471dd4b239f04844248a87
https://doi.org/10.1016/j.bmcl.2020.127405
https://doi.org/10.1016/j.bmcl.2020.127405
Autor:
Derek C. Cole, Benjamin Johnson, Petro Halkowycz, Douglas R. Dougan, Andrea Fanjul, Tony Gibson, Steven Swann
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(8)
Structure-based drug design is an iterative process that is an established means to accelerate lead optimization, and is most powerful when integrated with information from different sources. Herein is described the use of such methods in conjunction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0abaad67d7f6f5ab9269c484b009af65
https://pubmed.ncbi.nlm.nih.gov/28291695
https://pubmed.ncbi.nlm.nih.gov/28291695
Autor:
Josephine Atienza, Isaac Hoffman, Jason Kahana, Deepika Balakrishna, Ron de Jong, Amogh Boloor, Walter Keung, Petro Halkowycz, Kiryanov Andre A, J. David Lawson, Anthony R. Gangloff, Jason W. Brown, Pamela Farrell, Robert J. Skene
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(4)
Axl has been a target of interest in the oncology field for several years based on its role in various oncogenic processes. To date, no wild-type Axl crystal structure has been reported. Herein, we describe the structure-based optimization of a novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84146fc25876e811144f0d269a6346cf
https://pubmed.ncbi.nlm.nih.gov/28082036
https://pubmed.ncbi.nlm.nih.gov/28082036