Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Petrilla Jayaprakash"'
Autor:
Petrilla Jayaprakash, Dmytro Isaev, Keun-Hang Susan Yang, Rami Beiram, Murat Oz, Bassem Sadek
Publikováno v:
Pharmaceuticals, Vol 17, Iss 4, p 482 (2024)
Studying the involvement of nicotinic acetylcholine receptors (nAChRs), specifically α7-nAChRs, in neuropsychiatric brain disorders such as autism spectrum disorder (ASD) has gained a growing interest. The flavonoid apigenin (APG) has been confirmed
Externí odkaz:
https://doaj.org/article/bba029305b4c4ac9b0e217ca16ac2717
Autor:
Sabna Abdalla, Nermin Eissa, Petrilla Jayaprakash, Rami Beiram, Kamil J. Kuder, Dorota Łażewska, Katarzyna Kieć-Kononowicz, Bassem Sadek
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 16, p 12719 (2023)
The role of histamine H3 receptors (H3Rs) in memory and the prospective of H3R antagonists in pharmacological control of neurodegenerative disorders, e.g., Alzheimer’s disease (AD), is well-accepted. Therefore, the procognitive effects of acute sys
Externí odkaz:
https://doaj.org/article/23e23af10ddb4356b05b65ab4d10e065
Publikováno v:
Pharmaceuticals, Vol 16, Iss 5, p 769 (2023)
Based on their proven anti-inflammatory and antioxidant effects, recent studies have examined the therapeutic potential of the sodium-glucose cotransporter 2 (SGLT2) inhibitors in neurodevelopmental disorders such as autism spectrum disorder (ASD). T
Externí odkaz:
https://doaj.org/article/87d6745c04ee43d1a875736b141b8f95
Autor:
Nermin Eissa, Mohamed Al Awad, Shilu Deepa Thomas, Karthikkumar Venkatachalam, Petrilla Jayaprakash, Sicheng Zhong, Holger Stark, Bassem Sadek
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 526 (2022)
Dysregulation in brain neurotransmitters underlies several neuropsychiatric disorders, e.g., autism spectrum disorder (ASD). Also, abnormalities in the extracellular-signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) pathway pave t
Externí odkaz:
https://doaj.org/article/b592964444374c609604dc5fa9aab316
Autor:
Karthikkumar Venkatachalam, Nermin Eissa, Mohamed Al Awad, Petrilla Jayaprakash, Sicheng Zhong, Frauke Stölting, Holger Stark, Bassem Sadek
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 138, Iss , Pp 111517- (2021)
Several brain neurotransmitters, including histamine (HA), acetylcholine (ACh), and dopamine (DA) are suggested to be involved in several brain disorders including cognitive deficits, depression, schizophrenia, anxiety, and narcolepsy, all of which a
Externí odkaz:
https://doaj.org/article/e1d51c09029e44fe844f48f9e9d561b6
Autor:
Nermin Eissa, Karthikkumar Venkatachalam, Petrilla Jayaprakash, Priya Yuvaraju, Markus Falkenstein, Holger Stark, Bassem Sadek
Publikováno v:
Pharmaceuticals, Vol 15, Iss 8, p 929 (2022)
Altered regulation of neurotransmitters may lead to many pathophysiological changes in brain disorders including autism spectrum disorder (ASD). Given the fact that there are no FDA-approved effective treatments for the social deficits in ASD, the pr
Externí odkaz:
https://doaj.org/article/0efa1960988047b9b1c29fffbe458b20
Autor:
Petrilla Jayaprakash, Dmytro Isaev, Waheed Shabbir, Dietrich E. Lorke, Bassem Sadek, Murat Oz
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 14, p 7251 (2021)
Autistic spectrum disorder (ASD) refers to a group of neurodevelopmental disorders characterized by impaired social interaction and cognitive deficit, restricted repetitive behaviors, altered immune responses, and imbalanced oxidative stress status.
Externí odkaz:
https://doaj.org/article/93d9e3b491b446818d6edfa008051da3
Autor:
Nermin Eissa, Karthikkumar Venkatachalam, Petrilla Jayaprakash, Markus Falkenstein, Mariam Dubiel, Annika Frank, David Reiner-Link, Holger Stark, Bassem Sadek
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4, p 1947 (2021)
Autism spectrum disorder (ASD) is a complex heterogeneous neurodevelopmental disorder characterized by social and communicative impairments, as well as repetitive and restricted behaviors (RRBs). With the limited effectiveness of current pharmacother
Externí odkaz:
https://doaj.org/article/01a572bf17204c6297c946cfb7e908f6
Autor:
Nermin Eissa, Petrilla Jayaprakash, Holger Stark, Dorota Łażewska, Katarzyna Kieć-Kononowicz, Bassem Sadek
Publikováno v:
Biomolecules, Vol 10, Iss 9, p 1251 (2020)
Autism spectrum disorder (ASD) is a heterogenous neurodevelopmental disorder defined by persistent deficits in social interaction and the presence of patterns of repetitive and restricted behaviors. The central neurotransmitters histamine (HA) and ac
Externí odkaz:
https://doaj.org/article/a440167b3f204f0da88eb8efcf418c3d
Autor:
Nermin Eissa, Sheikh Azimullah, Petrilla Jayaprakash, Richard L. Jayaraj, David Reiner, Shreesh K. Ojha, Rami Beiram, Holger Stark, Dorota Łażewska, Katarzyna Kieć-Kononowicz, Bassem Sadek
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 11, p 3996 (2020)
The histamine H3 receptor (H3R) functions as auto- and hetero-receptors, regulating the release of brain histamine (HA) and acetylcholine (ACh), respectively. The enzyme acetylcholine esterase (AChE) is involved in the metabolism of brain ACh. Both b
Externí odkaz:
https://doaj.org/article/61598b170f66419eb2d0e6d7212fe877