BRCA1 genomic deletions are major founder mutations in Dutch breast cancer patients

Autor: Hanne Meijers-Heijboer, Egbert Bakker, M.J.L. Ligtenberg, Anne Petrij-Bosch, Tamara Peelen, M. Drusedau, Cees J. Cornelisse, R. Olmer, Peter Devilee, S. Hageman, Hans F. A. Vasen, L.J. van 't Veer, Jan G. M. Klijn, G.J.B. van Ommen, Frans B. L. Hogervorst, Peer Arts, M. van Vliet, R. van Eijk

Publikováno v: Nature Genetics, 17, 341-345
Nature Genetics, 17, 3, pp. 341-345
Nature Genetics, 17, pp. 341-345
Nature genetics, 17(3), 341-345. Nature Publishing Group

To date, more than 300 distinct small deletions, insertions and point mutations, mostly leading to premature termination of translation, have been reported in the breast/ovarian-cancer susceptibility gene BRCA1. The elevated frequencies of some mutat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72f5e60aebf7c879ed17cbc5d09d4da5
https://doi.org/10.1038/ng1197-341

A high proportion of novel mutations in BRCA1 with strong founder effects among Dutch and Belgian hereditary breast and ovarian cancer families

Autor: Peelen, T, van Vliet, M, Petrij-Bosch, A, Mieremet, R, Szabo, C, van den Ouweland, A M, Hogervorst, F, Brohet, R, Ligtenberg, M J, Teugels, E, van der Luijt, R, van der Hout, A H, Gille, J J, Pals, G, Jedema, I, Olmer, R, van Leeuwen, I, Newman, B, Plandsoen, M, van der Est, M, Brink, G, Hageman, S, Arts, P J, Bakker, M M, Devilee, P

Publikováno v: Peelen, T, van Vliet, M, Petrij-Bosch, A, Mieremet, R, Szabo, C, van den Ouweland, A M, Hogervorst, F, Brohet, R, Ligtenberg, M J, Teugels, E, van der Luijt, R, van der Hout, A H, Gille, J J, Pals, G, Jedema, I, Olmer, R, van Leeuwen, I, Newman, B, Plandsoen, M, van der Est, M, Brink, G, Hageman, S, Arts, P J, Bakker, M M & Devilee, P 1997, ' A high proportion of novel mutations in BRCA1 with strong founder effects among Dutch and Belgian hereditary breast and ovarian cancer families ', American journal of human genetics, vol. 60, no. 5, pp. 1041-9 .
American journal of human genetics, 60(5), 1041-9. Cell Press

We have identified 79 mutations in BRCA1 in a set of 643 Dutch and 23 Belgian hereditary breast and ovarian cancer families collected either for research or for clinical diagnostic purposes. Twenty-eight distinct mutations have been observed, 18 of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e77c1b66697cba59b1266b9edace05f9
https://research.vumc.nl/en/publications/21f059aa-38bd-428a-9b59-47074e11452b

BRCA1 genomic deletions are major founder mutations in Dutch breast cancer patients (vol 17, pg 341, 1997)

Autor: Petrij-Bosch, A., Peelen, T., van Vliet, M., van Eijk, R., Olmer, R., Drusedau, M., Hogervorst, F. B. L., Hageman, S., Arts, P. J. W., Ligtenberg, M. J. L., Meijers-Heijboer, H., Klijn, J. G. M., Vasen, H. F. A., Cornelisse, C. J., van't Veer, L. J., Bakker, E., van Ommen, G. J., Devilee, P.

Publikováno v: Nature genetics, 17(4). Nature Publishing Group

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::0562efd4e401673c7102bd67376070d3
https://pure.amc.nl/en/publications/brca1-genomic-deletions-are-major-founder-mutations-in-dutch-breast-cancer-patients-vol-17-pg-341-1997(8b1fe59f-146d-42c2-b203-5888194e9d38).html

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A high proportion of novel mutations in BRCA1 with strong founder effects among Dutch and Belgian hereditary breast and ovarian cancer families.

Autor: Peelen T; Department of Human Genetics, Leiden University Medical Center, The Netherlands., van Vliet M, Petrij-Bosch A, Mieremet R, Szabo C, van den Ouweland AM, Hogervorst F, Brohet R, Ligtenberg MJ, Teugels E, van der Luijt R, van der Hout AH, Gille JJ, Pals G, Jedema I, Olmer R, van Leeuwen I, Newman B, Plandsoen M, van der Est M, Brink G, Hageman S, Arts PJ, Bakker MM, Devilee P, et. al.

Publikováno v: American journal of human genetics [Am J Hum Genet] 1997 May; Vol. 60 (5), pp. 1041-9.