Ligand-based targeting of c-kit using engineered γδ T cells as a strategy for treating acute myeloid leukemia.

Autor: Branella GM; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, United States.; Graduate Division of Biological and Biomedical Sciences, Laney Graduate School, Emory University, Atlanta, GA, United States.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, United States., Lee JY; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, United States.; Graduate Division of Biological and Biomedical Sciences, Laney Graduate School, Emory University, Atlanta, GA, United States.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, United States., Okalova J; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, United States.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, United States.; Molecular Systems Pharmacology Program, Graduate Division of Biological and Biomedical Sciences, Laney Graduate School, Emory University, Atlanta, GA, United States., Parwani KK; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, United States.; Graduate Division of Biological and Biomedical Sciences, Laney Graduate School, Emory University, Atlanta, GA, United States.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, United States., Alexander JS; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, United States.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, United States., Arthuzo RF; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, United States.; Graduate Division of Biological and Biomedical Sciences, Laney Graduate School, Emory University, Atlanta, GA, United States.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, United States., Fedanov A; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, United States.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, United States., Yu B; Expression Therapeutics, Inc., Tucker, GA, United States., McCarty D; Expression Therapeutics, Inc., Tucker, GA, United States., Brown HC; Expression Therapeutics, Inc., Tucker, GA, United States., Chandrakasan S; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, United States.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, United States., Petrich BG; Expression Therapeutics, Inc., Tucker, GA, United States., Doering CB; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, United States.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, United States.; Molecular Systems Pharmacology Program, Graduate Division of Biological and Biomedical Sciences, Laney Graduate School, Emory University, Atlanta, GA, United States., Spencer HT; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, United States.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, United States.; Molecular Systems Pharmacology Program, Graduate Division of Biological and Biomedical Sciences, Laney Graduate School, Emory University, Atlanta, GA, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2023 Nov 13; Vol. 14, pp. 1294555. Date of Electronic Publication: 2023 Nov 13 (Print Publication: 2023).

Talin-dependent integrin activation is required for endothelial proliferation and postnatal angiogenesis.

Autor: Pulous FE; Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta, GA, USA., Carnevale JC; Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta, GA, USA., Al-Yafeai Z; Department of Molecular and Cellular Physiology, LSU Health Sciences Center, Shreveport, LA, USA., Pearson BH; Department of Molecular and Cellular Physiology, LSU Health Sciences Center, Shreveport, LA, USA., Hamilton JAG; Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta, GA, USA., Henry CJ; Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta, GA, USA., Orr AW; Department of Molecular and Cellular Physiology, LSU Health Sciences Center, Shreveport, LA, USA.; Department of Cell Biology and Anatomy, LSU Health Sciences Center, Shreveport, LA, USA.; Pathology and Translational Pathobiology, LSU Health Sciences Center, Shreveport, LA, USA., Petrich BG; Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta, GA, USA. brian.petrich@emory.edu.

Publikováno v: Angiogenesis [Angiogenesis] 2021 Feb; Vol. 24 (1), pp. 177-190. Date of Electronic Publication: 2020 Oct 28.

DNA-Based Microparticle Tension Sensors (μTS) for Measuring Cell Mechanics in Non-planar Geometries and for High-Throughput Quantification.

Autor: Hu Y; Department of Chemistry, Emory University, Atlanta, GA, 30322, USA., Ma VP; Department of Chemistry, Emory University, Atlanta, GA, 30322, USA., Ma R; Department of Chemistry, Emory University, Atlanta, GA, 30322, USA., Chen W; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Department of Pediatrics, Emory University, Atlanta, GA, 30322, USA., Duan Y; Department of Chemistry, Emory University, Atlanta, GA, 30322, USA., Glazier R; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30322, USA., Petrich BG; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Department of Pediatrics, Emory University, Atlanta, GA, 30322, USA., Li R; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Department of Pediatrics, Emory University, Atlanta, GA, 30322, USA., Salaita K; Department of Chemistry, Emory University, Atlanta, GA, 30322, USA.; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30322, USA.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2021 Aug 09; Vol. 60 (33), pp. 18044-18050. Date of Electronic Publication: 2021 Jun 28.

Dual role of endothelial Myct1 in tumor angiogenesis and tumor immunity.

Autor: Kabir AU; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110-1093, USA.; Molecular and Cell Biology Program, Washington University School of Medicine, St. Louis, MO 63110-1093, USA., Subramanian M; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110-1093, USA., Lee DH; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Wang X; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110-1093, USA., Krchma K; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110-1093, USA., Wu J; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110-1093, USA., Naismith T; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110-1093, USA., Halabi CM; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110-1093, USA., Kim JY; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Pulous FE; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Petrich BG; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Kim S; Department of Biomedical Sciences, College of Medicine, Korea University, Ansan 15335, Republic of Korea., Park HC; Department of Biomedical Sciences, College of Medicine, Korea University, Ansan 15335, Republic of Korea., Hanson PI; Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109-5624, USA., Pan H; Health Heart Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA., Wickline SA; Health Heart Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA., Fremont DH; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110-1093, USA., Park C; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA. cpar13@lsuhsc.edu kchoi@wustl.edu.; Department of Molecular and Cellular Physiology, Louisiana State University Health Science Center, Shreveport, LA 71103, USA., Choi K; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110-1093, USA. cpar13@lsuhsc.edu kchoi@wustl.edu.; Molecular and Cell Biology Program, Washington University School of Medicine, St. Louis, MO 63110-1093, USA.; Graduate School of Biotechnology, Kyung Hee University, Yong In 17104, Republic of Korea.

Publikováno v: Science translational medicine [Sci Transl Med] 2021 Mar 03; Vol. 13 (583).

Significant differences in single-platelet biophysics exist across species but attenuate during clot formation.

Autor: Oshinowo O; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA.; Department of Pediatrics, Aflac Cancer Center and Blood Disorders Service, Children's Healthcare of Atlanta, Emory University School of Medicine, Emory University, Atlanta, GA.; Parker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA.; Winship Cancer Institute and., Copeland R; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA.; Department of Pediatrics, Aflac Cancer Center and Blood Disorders Service, Children's Healthcare of Atlanta, Emory University School of Medicine, Emory University, Atlanta, GA.; Parker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA.; Winship Cancer Institute and., Sakurai Y; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA.; Department of Pediatrics, Aflac Cancer Center and Blood Disorders Service, Children's Healthcare of Atlanta, Emory University School of Medicine, Emory University, Atlanta, GA.; Parker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA.; Winship Cancer Institute and., Fay ME; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA.; Department of Pediatrics, Aflac Cancer Center and Blood Disorders Service, Children's Healthcare of Atlanta, Emory University School of Medicine, Emory University, Atlanta, GA.; Parker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA.; Winship Cancer Institute and., Petrich BG; Department of Pediatrics, Aflac Cancer Center and Blood Disorders Service, Children's Healthcare of Atlanta, Emory University School of Medicine, Emory University, Atlanta, GA., Leong T; Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA; and., Brainard B; Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA., Lam WA; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA.; Department of Pediatrics, Aflac Cancer Center and Blood Disorders Service, Children's Healthcare of Atlanta, Emory University School of Medicine, Emory University, Atlanta, GA.; Parker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA.; Winship Cancer Institute and.

Publikováno v: Blood advances [Blood Adv] 2021 Jan 26; Vol. 5 (2), pp. 432-437.