Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Petric Kuballa"'
Publikováno v:
PLoS ONE, Vol 3, Iss 10, p e3391 (2008)
The genetic risk factors predisposing individuals to the development of inflammatory bowel disease are beginning to be deciphered by genome-wide association studies. Surprisingly, these new data point towards a critical role of autophagy in the patho
Externí odkaz:
https://doaj.org/article/828174e611e54aa59d321e9cefa602f2
Autor:
Alexander, Klimke, Steffen, Güttler, Petric, Kuballa, Simone, Janzen, Sonja, Ortmann, Adriano, Flora
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1953
The use of CRISPR/Cas9 to modify the mouse genome has gained immense interest in the past few years since it allows the direct modification of embryos, bypassing the need of labor-intensive procedures for the manipulation of embryonic stem cells. By
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cf5c751c4e7d00a1bb95cd9341bbc003
https://pubmed.ncbi.nlm.nih.gov/30912024
https://pubmed.ncbi.nlm.nih.gov/30912024
Publikováno v:
Molecular Genetics of Inflammatory Bowel Disease ISBN: 9783030287023
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::649afa3b4bfcfa3502557b9ae26a3f91
https://doi.org/10.1007/978-3-030-28703-0_14
https://doi.org/10.1007/978-3-030-28703-0_14
Autor:
Adriano Flora, Steffen Güttler, Simone Janzen, Sonja Ortmann, Alexander Klimke, Petric Kuballa
Publikováno v:
Target Identification and Validation in Drug Discovery ISBN: 9781493991440
The use of CRISPR/Cas9 to modify the mouse genome has gained immense interest in the past few years since it allows the direct modification of embryos, bypassing the need of labor-intensive procedures for the manipulation of embryonic stem cells. By
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4907abefb4e727ad412bd61b3eca9d62
https://doi.org/10.1007/978-1-4939-9145-7_13
https://doi.org/10.1007/978-1-4939-9145-7_13
Autor:
Moshe Biton, Ramnik J. Xavier, John D. Gagnon, Noga Rogel, Leigh A. Baxt, Petric Kuballa, Kara G. Lassen, Bernard Khor, Jakob Begun, Kara L. Conway, Abdifatah S. Omar, Aviv Regev, Adam L. Haber
Publikováno v:
PMC
J Immunol
J Immunol
The clear role of autophagy in human inflammatory diseases such as Crohn disease was first identified by genome-wide association studies and subsequently dissected in multiple mechanistic studies. ATG16L1 has been particularly well studied in knockou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29df94faf92625097b53e67e249e7991
https://hdl.handle.net/1721.1/128135
https://hdl.handle.net/1721.1/128135
Publikováno v:
FEBS Letters. 589:1450-1458
Genome-wide transcript profiling to elucidate responses to HSP90 inhibition revealed strong induction of HSPA6 in MCF-7 cells treated with 17-AAG. Time- and dose dependent induction of HSPA6 (confirmed by qPCR and Western Blots) occurred also upon tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d217662951b1647efb22ae821e7bae6c
https://doi.org/10.1016/j.febslet.2015.04.053
https://doi.org/10.1016/j.febslet.2015.04.053
Autor:
Alykhan F. Shamji, Ramnik J. Xavier, Gautam Goel, Szu Yu Kuo, Adam B. Castoreno, Jaime H. Cheah, Petric Kuballa, Matthew G. Rees, Stuart L. Schreiber, Isabel J. Latorre, Leslie N. Aldrich, Brinton Seashore-Ludlow
Publikováno v:
Journal of the American Chemical Society
Lysosomes perform a critical cellular function as a site of degradation for diverse cargoes including proteins, organelles, and pathogens delivered through distinct pathways, and defects in lysosomal function have been implicated in a number of disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b531db4c770858384b6f63c05d88e7
https://doi.org/10.1021/jacs.5b02150
https://doi.org/10.1021/jacs.5b02150
Autor:
Christine Becker, Petric Kuballa, Johnathan Mercer, Herbert W. Virgin, Kara G. Lassen, Heiko Horn, Stuart L. Schreiber, Ömer H. Yilmaz, Steven A. Carr, Ta-Chiang Liu, Kara L. Conway, Alykhan F. Shamji, Jason M. Norman, Atul K. Bhan, Eduardo J. Villablanca, Jacob D. Jaffe, Morgan L. Becker, Robert J. Heath, Lola Fagbami, Khushbu Patel, Thaddeus S. Stappenbeck, Ramnik J. Xavier, Mark J. Daly, Joanna M. Peloquin
Publikováno v:
Proceedings of the National Academy of Sciences. 111:7741-7746
A coding polymorphism (Thr300Ala) in the essential autophagy gene, autophagy related 16-like 1 (ATG16L1), confers increased risk for the development of Crohn disease, although the mechanisms by which single disease-associated polymorphisms contribute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e699aba15d5ef8ce4e1a5b0f96d4d67
https://doi.org/10.1073/pnas.1407001111
https://doi.org/10.1073/pnas.1407001111
Publikováno v:
Annual Review of Immunology. 30:611-646
Stressors ranging from nutrient deprivation to immune signaling can induce the degradation of cytoplasmic material by a process known as autophagy. Increasingly, research on autophagy has begun to focus on its role in inflammation and the immune resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d378ac35f8c1e0089b5bc1cddec0b6f4
https://doi.org/10.1146/annurev-immunol-020711-074948
https://doi.org/10.1146/annurev-immunol-020711-074948
Autor:
Petric Kuballa, Ramnik J. Xavier
Publikováno v:
Seminars in Immunopathology. 32:319-322
Autophagy is a cellular disposal system directing cargoes into lysosomes, where the substrates, ranging from proteins to pathogens, are finally subjected to proteolytic cleavage. It is well-known as a “provider” of anabolic building blocks under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b551604ec4a78d98b18f82708b6cde9e
https://doi.org/10.1007/s00281-010-0229-5
https://doi.org/10.1007/s00281-010-0229-5