Zobrazeno 1 - 10
of 609
pro vyhledávání: '"Petri T Kovanen"'
Autor:
Katariina Nurmi, Katri Niemi, Ilona Kareinen, Kristiina Silventoinen, Martina B Lorey, Yan Chen, Vesa‐Petteri Kouri, Jukka Parantainen, Timo Juutilainen, Katariina Öörni, Petri T Kovanen, Dan Nordström, Sampsa Matikainen, Kari K Eklund
Publikováno v:
Clinical & Translational Immunology, Vol 10, Iss 8, Pp n/a-n/a (2021)
Abstract Objectives The NLRP3 inflammasome plays a key role in arterial wall inflammation. In this study, we elucidated the role of serum lipoproteins in the regulation of NLRP3 inflammasome activation by serum amyloid A (SAA) and other inflammasome
Externí odkaz:
https://doaj.org/article/758af8f4859648f6b84a88fa15cc16c5
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e108352 (2014)
Activated mast cells in atherosclerotic lesions degranulate and release bioactive compounds capable of regulating atherogenesis. Here we examined the ability of activated human primary mast cells to regulate the expression of the major scavenger rece
Externí odkaz:
https://doaj.org/article/0896c51494fb484d9062d0e165942e4d
Autor:
Satu Lehti, Reijo Käkelä, Sohvi Hörkkö, Outi Kummu, Satu Helske-Suihko, Markku Kupari, Kalervo Werkkala, Petri T Kovanen, Katariina Oörni
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65810 (2013)
In aortic stenosis plasma lipoprotein-derived lipids accumulate in aortic valves. Here, we first compared the lipid compositions of stenotic aortic valves and atherosclerotic plaque cores. Both pathological tissues were found to be enriched in choles
Externí odkaz:
https://doaj.org/article/ddfa985d64a6433b91d865f292db20ea
Autor:
Katariina Nurmi, Juhani Virkanen, Kristiina Rajamäki, Katri Niemi, Petri T Kovanen, Kari K Eklund
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e78537 (2013)
In the pathogenesis of coronary atherosclerosis, local macrophage-driven inflammation and secretion of proinflammatory cytokines, interleukin-1β (IL-1β) in particular, are recognized as key factors. Moderate alcohol consumption is associated with a
Externí odkaz:
https://doaj.org/article/bd01f144a9994d559d234deb3ed39a46
Autor:
Petri T. Kovanen, Alpo Vuorio
Publikováno v:
Atherosclerosis Plus, Vol 53, Iss , Pp 1-5 (2023)
In this short narrative review, we aim at defining the pathophysiological role endothelial dysfunction in the observed COVID-19–associated rise in risk of cardiovascular disease. Variants of the SARS-CoV-2 virus have caused several epidemic waves o
Externí odkaz:
https://doaj.org/article/7f7fe1bdf35a4a1c9748b0275fcdde00
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 1, p e1002299 (2012)
Cholesteryl ester transfer protein (CETP) transports cholesteryl esters, triglycerides, and phospholipids between different lipoprotein fractions in blood plasma. The inhibition of CETP has been shown to be a sound strategy to prevent and treat the d
Externí odkaz:
https://doaj.org/article/2eadda8f583147b290927858ef3ba367
Autor:
Vibhor Kumar, Sarah J Butcher, Katariina Öörni, Peter Engelhardt, Jukka Heikkonen, Kimmo Kaski, Mika Ala-Korpela, Petri T Kovanen
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e18841 (2011)
BackgroundLow-density lipoprotein (LDL) particles, the major carriers of cholesterol in the human circulation, have a key role in cholesterol physiology and in the development of atherosclerosis. The most prominent structural components in LDL are th
Externí odkaz:
https://doaj.org/article/3bc145db1cc642a99f5f82be6aca3aa0
Autor:
Kristiina Rajamäki, Jani Lappalainen, Katariina Oörni, Elina Välimäki, Sampsa Matikainen, Petri T Kovanen, Kari K Eklund
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11765 (2010)
Chronic inflammation of the arterial wall is a key element in the pathogenesis of atherosclerosis, yet the factors that trigger and sustain the inflammation remain elusive. Inflammasomes are cytoplasmic caspase-1-activating protein complexes that pro
Externí odkaz:
https://doaj.org/article/47f674a61a6042f7be9acff3813af17c
Autor:
Kristiina Kanerva, Jani Lappalainen, Laura T Mäkitie, Susanna Virolainen, Petri T Kovanen, Leif C Andersson
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6858 (2009)
BACKGROUND:Upon IgE-mediated activation, mast cells (MC) exocytose their cytoplasmic secretory granules and release a variety of bioactive substances that trigger inflammatory responses. Polyamines mediate numerous cellular and physiological function
Externí odkaz:
https://doaj.org/article/e94643029eb7401885028514e57da3e1
Publikováno v:
Annals of Medicine, Vol 55, Iss 1 (2023)
AbstractPatients with hypercholesterolemia often have coronary microvascular dysfunction (CMD). Viral infections, such as the SARS-CoV-2 infection, may also result in CMD. Three non-randomized studies have shown significant beneficial effects of stat
Externí odkaz:
https://doaj.org/article/49707ce65fe74a84b18382cd7f685ee8