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Characterization of a novel OX40 ligand and CD40 ligand-expressing oncolytic adenovirus used in the PeptiCRAd cancer vaccine platform

Autor: Erkko Ylösmäki, Leena Ylösmäki, Manlio Fusciello, Beatriz Martins, Petra Ahokas, Hanne Cojoc, Arttu Uoti, Sara Feola, Anna Kreutzman, Tuuli Ranki, Julia Karbach, Tapani Viitala, Petri Priha, Elke Jäger, Sari Pesonen, Vincenzo Cerullo

Publikováno v: Molecular Therapy: Oncolytics, Vol 20, Iss , Pp 459-469 (2021)

Oncolytic viruses (OVs) have been shown to induce anti-cancer immunity and enhance cancer immunotherapies, such as immune checkpoint inhibitor therapies. OV therapies can be further improved by arming OVs with immunostimulatory molecules, including v

Externí odkaz: https://doaj.org/article/249495d6c67844b0b08173d27d8abb6a

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Abstract B123: Local treatment with PeptiCRAd-1, a novel cancer immunotherapy approach, mediates a systemic antitumour CD8+ T-cell response and infiltration of CD8+ and CD4+ T-cells into distant untreated tumors in a clinically relevant humanized mouse melanoma model

Autor: Erkko Ylösmäki, Vincenzo Cerullo, Sari Pesonen, Charlotta Backman, Matthew Vaughn, Petri Priha, Tuuli Ranki

Publikováno v: Cancer Immunology Research. 7:B123-B123

Multiple oncolytic viruses (OV) are currently in clinical development as cancer immunotherapy candidates, due to their high immunogenicity and immune activation capacity. However, only anecdotal clinical evidence for OV-mediated tumor-specific immune

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e41e5dfd4abdd77999e68da51fa493b
https://doi.org/10.1158/2326-6074.cricimteatiaacr18-b123

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Phase I study with ONCOS-102 for the treatment of solid tumors – an evaluation of clinical response and exploratory analyses of immune markers

Publikováno v: Journal for Immunotherapy of Cancer

We conducted a phase I study with a granulocyte macrophage colony stimulating factor (GMCSF)-expressing oncolytic adenovirus, ONCOS-102, in patients with solid tumors refractory to available treatments. The objectives of the study were to determine t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d5ca2cc3e2ac5b0472e34724c7f0155
http://europepmc.org/articles/PMC4791966

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Local treatment of a pleural mesothelioma tumor with ONCOS-102 induces a systemic antitumor CD8(+) T-cell response, prominent infiltration of CD8(+) lymphocytes and Th1 type polarization

Publikováno v: Oncoimmunology

Late stage cancer is often associated with reduced immune recognition and a highly immunosuppressive tumor microenvironment. The presence of tumor infiltrating lymphocytes (TILs) and specific gene-signatures prior to treatment are linked to good prog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c204f983d0932a4cd45c57626fb4f437
http://hdl.handle.net/10138/225325

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Effect of copper on membrane lipids and on methane monooxygenase activity of Methylococcus capsulatus (Bath)

Autor: Petri Peltola, Petri Priha, Simo Laakso

Publikováno v: Archives of Microbiology. 159:521-525

The effect of copper supplementation on growth, methane monooxygenase activity and lipid composition of Methylococcus capsulatus (Bath) was studied. Copper increased biomass yield, methane monooxygenase activity and phospholipid content from 7.7 to 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17b6319f401975b791ea3cc5212a3439
https://doi.org/10.1007/bf00249029

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Repeated intratumoral administration of ONCOS-102 leads to systemic antitumor CD8+T-cell response and robust cellular and transcriptional immune activation at tumor site in a patient with ovarian cancer

Publikováno v: OncoImmunology. 4:e1017702

Adenoviruses are excellent immunotherapeutic agents with a unique ability to prime and boost immune responses. Recombinant adenoviruses cause immunogenic cancer cell death and subsequent release of tumor antigens for antigen presenting cells, resulti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f56748782b9e374c24011f7b8ecf144
https://doi.org/10.1080/2162402x.2015.1017702

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