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Long-term stability of clinical-grade lentiviral vectors for cell therapy.

Autor: Jadlowsky JK; Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Leskowitz R; Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., McKenna S; Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Karar J; Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Ma Y; Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Dai A; Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Plesa G; Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Chen F; Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Alexander K; Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Petrella J; Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Gong N; Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Hwang WT; Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104, USA., Farrelly O; Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Barber-Rotenberg J; Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Christensen S; Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Gonzalez VE; Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Chew A; Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Fraietta JA; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., June CH; Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.; Parker Institute for Cancer Immunotherapy at the University of Pennsylvania, Philadelphia, PA 19104, USA.

Publikováno v: Molecular therapy. Methods & clinical development [Mol Ther Methods Clin Dev] 2024 Jan 10; Vol. 32 (1), pp. 101186. Date of Electronic Publication: 2024 Jan 10 (Print Publication: 2024).

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872 - Process Development and Manufacturing: DEVELOPMENT AND FEASIBILITY OF RELEASE ASSAYS TO TEST FOR CD33-KNOCKOUT EFFICIENCY AND POTENCY OF GENE-MODIFIED CD34+ HSCS FOR LARGE-SCALE MANUFACTURED PRODUCTS

Autor: Petrella, J., Dai, A., Mackey, S., Ngo, S., Brennan, A.L., Correa, A., Colligon, T.A., Tran, K., Buchholz, K., Plesa, G., Siegel, D.

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