Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Petras P Dzeja"'
Autor:
Eugenia Trushina, Emirhan Nemutlu, Song Zhang, Trace Christensen, Jon Camp, Janny Mesa, Ammar Siddiqui, Yasushi Tamura, Hiromi Sesaki, Thomas M Wengenack, Petras P Dzeja, Joseph F Poduslo
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32737 (2012)
The identification of early mechanisms underlying Alzheimer's Disease (AD) and associated biomarkers could advance development of new therapies and improve monitoring and predicting of AD progression. Mitochondrial dysfunction has been suggested to u
Externí odkaz:
https://doaj.org/article/e9f4c61c946440419d7386cc8cc29d9e
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19300 (2011)
Energetic and metabolic circuits that orchestrate cell differentiation are largely unknown. Adenylate kinase (AK) and associated AMP-activated protein kinase (AMPK) constitute a major metabolic signaling axis, yet the role of this system in guiding d
Externí odkaz:
https://doaj.org/article/b92a2878f2c34e94bb13f9bb1eb0d960
Autor:
Maria J Forteza, Martin Berg, Andreas Edsfeldt, Jangming Sun, Roland Baumgartner, Ilona Kareinen, Felipe Beccaria Casagrande, Ulf Hedin, Song Zhang, Ivan Vuckovic, Petras P Dzeja, Konstantinos A Polyzos, Anton Gisterå, Mette Trauelsen, Thue W Schwartz, Lea Dib, Joerg Herrmann, Claudia Monaco, Ljubica Matic, Isabel Gonçalves, Daniel F J Ketelhuth
Publikováno v:
Cardiovascular Research.
AimsRecent studies have revealed a close connection between cellular metabolism and the chronic inflammatory process of atherosclerosis. While the link between systemic metabolism and atherosclerosis is well established, the implications of altered m
Autor:
Janane F. Rahbani, LeeAnn C Ramsay, Petras P. Dzeja, Danielle Tenen, Gina Z. Lu, Florence Y. Dou, Bruce M. Spiegelman, Song Zhang, Lawrence Kazak, Linus T.-Y. Tsai, Mathieu Lajoie, Evan D. Rosen, Edward T. Chouchani, Ian R. Watson, Mark P. Jedrychowski, Bozena Samborska
Publikováno v:
Nature metabolism
Depleting creatine levels in thermogenic adipocytes by inhibiting creatine biosynthesis reduces thermogenesis and causes obesity. However, whether creatine import from the circulation affects adipocyte thermogenesis is unknown. Here we show that dele
Autor:
Song Zhang, Aleksandr Klepinin, Petras P. Dzeja, Andre Terzic, Tuuli Kaambre, Satsuki Yamada, Sungjo Park
Publikováno v:
Biochem Biophys Res Commun
Adenylate kinase 2 (AK2) catalyzes trans-compartmental nucleotide exchange, but the functional implications of this mitochondrial intermembrane isoform is only partially understood. Here, transgenic AK2−/− null homozygosity was lethal early in em
Autor:
Benjamin Gateno, Tara O’Hagan, Michael K. Lee, Xiujuan Zhu, Yu Yamazaki, Joel M. Reid, Andrea Stojakovic, Takahisa Kanekiyo, Su-Youne Chang, Song Zhang, Renee A. Schoon, Tamar Pirtskhalava, Rachel E. Geroux, Xing Li, Ye In Christopher Kwon, Trace A. Christensen, Eugenia Trushina, Jeffrey L. Salisbury, Slobodan Macura, Cory C. Funk, Mrunal Dehankar, James L. Kirkland, Petras P. Dzeja, Utkarsh Tripathi, Jarred J. Nesbitt, Adam Jaspersen, Tamar Tchkonia, Padraig J. Flannery, Sergey Trushin, Emirhan Nemutlu, Jordan Wilkins, Alexander Galkin, Anna Stepanova, Anthony Sheu, Layla Khalili, Rachel A. Kudgus
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-20 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-20 (2021)
Alzheimer’s Disease (AD) is a devastating neurodegenerative disorder without a cure. Here we show that mitochondrial respiratory chain complex I is an important small molecule druggable target in AD. Partial inhibition of complex I triggers the AMP
Autor:
Tamar Pirtskhalava, Trace A. Christensen, Emirhan Nemutlu, Mrunal Dehankar, Utkarsh Tripathi, Adam Jaspersen, Anthony Sheu, Sergey Trushin, Eugenia Trushina, Tamar Tchkonia, Christopher Ye In Kwon, Su-Youne Chang, Song Zhang, James L. Kirkland, Xing Li, Xiujuan Zhu, Slobodan Macura, Jordan Wilkins, Layla Khalili, Rachel A. Kudgus, Andrea Stojakovic, Jeffrey L. Salisbury, Alexander Galkin, Jarred J. Nesbitt, Petras P. Dzeja, Padraig J. Flannery, Joel M. Reid, Renee A. Schoon, Takahisa Kanekiyo, Anna Stepanova, Tara O’Hagan, Michael K. Lee, Yu Yamazaki, Rachel E. Geroux, Cory C. Funk, Benjamin Gateno
We demonstrate that mitochondrial respiratory chain complex I is an important small molecule druggable target in Alzheimer’s Disease (AD). Partial inhibition of complex I triggers the AMP-activated protein kinase-dependent signaling network leading
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9277825fbc16e4b867cbddafb5528dbf
https://doi.org/10.1101/2020.07.01.182428
https://doi.org/10.1101/2020.07.01.182428
Autor:
Song Zhang, Egle Rebane-Klemm, Tuuli Kaambre, Aleksandr Klepinin, Petras P. Dzeja, Ljudmila Klepinina, Andre Terzic
Publikováno v:
Frontiers in Oncology
Frontiers in Oncology, Vol 10 (2020)
Frontiers in Oncology, Vol 10 (2020)
A hallmark of cancer cells is the ability to rewire their bioenergetics and metabolic signaling circuits to fuel their uncontrolled proliferation and metastasis. Adenylate kinase (AK) is the critical enzyme in the metabolic monitoring of cellular ade
Autor:
Hidetaka Shiratori, Claudius Werner, Kavita Praveen, Stef J.F. Letteboer, Petra Pennekamp, Petras P. Dzeja, Katrin Junger, Inga M. Höben, Franziska Rabert, Friederike Stumme, Julia Wallmeier, Isabella Aprea, Zeev Perles, Erica E. Davis, Judith A. Klinkenbusch, Israel Amirav, Yasin Memari, Yayoi Ikawa, Niki T. Loges, Diana Bracht, Wang Kyaw Twan, Kerstin Bartscherer, Tabea Nöthe-Menchen, Micha Aviram, Yuan Ping Pang, Rim Hjeij, Johanna Raidt, Heike Olbrich, Huda Mussaffi, Katsutoshi Mizuno, Nicola Horn, Timo Strünker, Heymut Omran, Sandra Cindric, Asaf Ta-Shma, Gerard W. Dougherty, Katsuyoshi Takaoka, Marius Ueffing, Thomas Kaiser, Katsura Minegishi, Jörg Große-Onnebrink, Hiroshi Hamada, Jana Gützlaff, Bernd Dworniczak, Luisa Biebach, Samuel M. Young, Orly Elpeleg, Nicholas Katsanis, Karsten Boldt, Takahiro Ide, Ronald Roepman
Publikováno v:
Nature Communications, 11
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Nature Communications
Nature Communications, 11, 1
Nature Communications, 11(1). Nature Publishing Group
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Nature Communications
Nature Communications, 11, 1
Nature Communications, 11(1). Nature Publishing Group
Axonemal dynein ATPases direct ciliary and flagellar beating via adenosine triphosphate (ATP) hydrolysis. The modulatory effect of adenosine monophosphate (AMP) and adenosine diphosphate (ADP) on flagellar beating is not fully understood. Here, we de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d88a83337a6f0f647e8e4ba37a5d642
http://hdl.handle.net/2066/229376
http://hdl.handle.net/2066/229376
Publikováno v:
Pacing and Clinical Electrophysiology. 39:1404-1409
Heart failure (HF) is associated with changes in cardiac substrate utilization and energy metabolism, including a decline in high-energy phosphate content, mitochondrial dysfunction, and phosphotransfer enzyme deficiency. A shift toward glucose metab