Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Petranel Ferrao"'
Publikováno v:
Journal of Molecular Graphics and Modelling. 23:139-152
The receptor tyrosine kinase, KIT, displays activating mutations in the kinase domain, which are associated with various cancers. We have used homology modelling based on the crystal structures of the insulin receptor kinase in active and inactive co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceaf6b4fce77ef61785c28f1bb0a630f
https://doi.org/10.1016/j.jmgm.2004.04.003
https://doi.org/10.1016/j.jmgm.2004.04.003
Publikováno v:
Leukemia Research. 25:395-405
Drug compartmentalization as well as drug efflux can contribute to drug resistance. We demonstrate the presence of P-gp in intracellular vesicles in certain AML cell lines and show localization of DNR to a similar subcellular compartment(s) that can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eab5f3f38fdd08c578424f6f1a48a13
https://doi.org/10.1016/s0145-2126(00)00156-9
https://doi.org/10.1016/s0145-2126(00)00156-9
Publikováno v:
Leukemia & Lymphoma. 34:451-461
Activating mutations in c-Kit, the receptor for Stem Cell Factor (SCF), have been identified in dysplasias and leukaemias of the mast cell lineage and have been shown to contribute to transformation in model systems. Early myeloid cells also normally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20a944357db97a65042df9db2762bd33
https://doi.org/10.3109/10428199909058472
https://doi.org/10.3109/10428199909058472
Publikováno v:
Blood. 90:4539-4552
The cDNAs encoding wild type (WT) human receptor tyrosine kinase c-Kit and a constitutively activated mutant, V816Kit, were introduced into granulocyte-macrophage colony-stimulating factor (GM-CSF )-dependent early murine hemopoietic cells, which had
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e87444ddd38f5b766aeef342933eef9
https://doi.org/10.1182/blood.v90.11.4539
https://doi.org/10.1182/blood.v90.11.4539
Autor:
Petranel Ferrao, Cliff Meldrum, E. Upjohn, Renate Griffith, George Varigos, Leonie K. Ashman, Ellen M. Byrnes, Rodney J. Scott, Gayle Ross, A. Braue, R. Foster
Publikováno v:
British Journal of Dermatology.
Summary Background The receptor tyrosine kinase c-KIT plays a key role in normal mast cell development. Point mutations in c-KIT have been associated with sporadic or familial mastocytosis. Objectives Two unrelated pairs of apparently identical twins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7556a337ef632d624c7431ef335e57c
https://doi.org/10.1111/j.1365-2133.2008.08827.x
https://doi.org/10.1111/j.1365-2133.2008.08827.x
Publikováno v:
Blood. 102(13)
Elevated expression of multidrug efflux pumps such as P-glycoprotein (Pgp) have been associated with resistance to cytotoxic drugs used in the treatment of leukemias and other cancers. Imatinib mesylate (STI-571 or Gleevec) is a potent inhibitor of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89d64cb0dfac59629b180754a5721a96
https://pubmed.ncbi.nlm.nih.gov/12881321
https://pubmed.ncbi.nlm.nih.gov/12881321
Publikováno v:
Leukemia research. 27(6)
Mutations of Kit at position D816 have been implicated in mastocytosis, acute myeloid leukaemia and germ cell tumours. Expression of this mutant Kit in cell lines results in factor-independent growth, differentiation and increased survival in vitro a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::893a6e1c6dbfcfad9722ffadbb9904a6
https://pubmed.ncbi.nlm.nih.gov/12648515
https://pubmed.ncbi.nlm.nih.gov/12648515
Autor:
RuJu Chian, Diana Linnekin, Leonie K. Ashman, Alla Danilkovitch-Miagkova, Sonia Young, Lars Rönnstrand, Edward J. Leonard, Petranel Ferrao
Publikováno v:
Blood. 98(5)
Stem cell factor (SCF) binds the receptor tyrosine kinase c-Kit and is critical for normal hematopoiesis. Substitution of valine for aspartic acid 816 (D816V) constitutively actives human c-Kit, and this mutation is found in patients with mastocytosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a809a4bc45911b4de7a401c2759d668a
https://pubmed.ncbi.nlm.nih.gov/11520784
https://pubmed.ncbi.nlm.nih.gov/11520784
Publikováno v:
Leukemia Research. 25:827
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::700ed80c7f1e7eef65101a9d1febc198
https://doi.org/10.1016/s0145-2126(01)00120-5
https://doi.org/10.1016/s0145-2126(01)00120-5
Autor:
Edward J. Leonard, A. Danilkovitch-Miagkova, Diana Linnekin, R. Chian, Lars Rönnstrand, S. Young, Petranel Ferrao, Leonie K. Ashman
Publikováno v:
Experimental Hematology. 28:1491
C-Kit is a receptor tyrosine kinase that binds stem cell factor. Substitution of valine for aspartic acid 816 (V816) constitutively activates human c-Kit and this mutation is found in patients with mastocytosis, leukemia and germ cells tumors. Transd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::830cd3b47f2524a1ef67eddc94584102
https://doi.org/10.1016/s0301-472x(00)00562-2
https://doi.org/10.1016/s0301-472x(00)00562-2