Decreased extrasynaptic δ‐GABAA receptors in PNN‐associated parvalbumin interneurons correlates with anxiety in APP and tau mouse models of Alzheimer's disease.

Autor: Zhang, Weicong, Liu, Tiansheng, Li, Jialin, Singh, Jaijeet, Chan, Andi, Islam, Anam, Petrache, Alexandra, Peng, Yunan, Harvey, Kirsten, Ali, Afia B.

Publikováno v: British Journal of Pharmacology; Oct2024, Vol. 181 Issue 20, p3944-3975, 32p

Aberrant Excitatory–Inhibitory Synaptic Mechanisms in Entorhinal Cortex Microcircuits During the Pathogenesis of Alzheimer’s Disease

Autor: Petrache, Alexandra L, Rajulawalla, Aarib, Shi, Anqi, Wetzel, Andrea, Saito, Takashi, Saido, Takaomi C, Harvey, Kirsten, Ali, Afia B

Publikováno v: Cerebral Cortex (New York, NY)

Synaptic dysfunction is widely proposed as an initial insult leading to the neurodegeneration observed in Alzheimer’s disease (AD). We hypothesize that the initial insult originates in the lateral entorhinal cortex (LEC) due to deficits in key inte

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http://europepmc.org/articles/PMC6418384

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Decreased extrasynaptic δ-GABA A receptors in PNN-associated parvalbumin interneurons correlates with anxiety in APP and tau mouse models of Alzheimer's disease.

Autor: Zhang W; UCL School of Pharmacy, London, UK., Liu T; UCL School of Pharmacy, London, UK., Li J; UCL School of Pharmacy, London, UK., Singh J; UCL School of Pharmacy, London, UK., Chan A; UCL School of Pharmacy, London, UK., Islam A; UCL School of Pharmacy, London, UK., Petrache A; UCL School of Pharmacy, London, UK., Peng Y; UCL School of Pharmacy, London, UK., Harvey K; UCL School of Pharmacy, London, UK., Ali AB; UCL School of Pharmacy, London, UK.

Publikováno v: British journal of pharmacology [Br J Pharmacol] 2024 Oct; Vol. 181 (20), pp. 3944-3975. Date of Electronic Publication: 2024 Jun 17.