Strongly Truncated Dnaaf4 Plays a Conserved Role in Drosophila Ciliary Dynein Assembly as Part of an R2TP-Like Co-Chaperone Complex With Dnaaf6

Autor: Jennifer Lennon, Petra zur Lage, Alex von Kriegsheim, Andrew P. Jarman

Publikováno v: Frontiers in Genetics, Vol 13 (2022)

Axonemal dynein motors are large multi-subunit complexes that drive ciliary movement. Cytoplasmic assembly of these motor complexes involves several co-chaperones, some of which are related to the R2TP co-chaperone complex. Mutations of these genes i

Externí odkaz: https://doaj.org/article/bf562fc50d3c4d89923566c56e172ab9

Survey of the Ciliary Motility Machinery of Drosophila Sperm and Ciliated Mechanosensory Neurons Reveals Unexpected Cell-Type Specific Variations: A Model for Motile Ciliopathies

Autor: Petra zur Lage, Fay G. Newton, Andrew P. Jarman

Publikováno v: Frontiers in Genetics, Vol 10 (2019)

The motile cilium/flagellum is an ancient eukaryotic organelle. The molecular machinery of ciliary motility comprises a variety of cilium-specific dynein motor complexes along with other complexes that regulate their activity. Assembling the motors r

Externí odkaz: https://doaj.org/article/59da76133cc24f7cbf1ba4d51bde40f4

HEATR2 plays a conserved role in assembly of the ciliary motile apparatus.

Autor: Christine P Diggle, Daniel J Moore, Girish Mali, Petra zur Lage, Aouatef Ait-Lounis, Miriam Schmidts, Amelia Shoemark, Amaya Garcia Munoz, Mihail R Halachev, Philippe Gautier, Patricia L Yeyati, David T Bonthron, Ian M Carr, Bruce Hayward, Alexander F Markham, Jilly E Hope, Alex von Kriegsheim, Hannah M Mitchison, Ian J Jackson, Bénédicte Durand, Walter Reith, Eamonn Sheridan, Andrew P Jarman, Pleasantine Mill

Publikováno v: PLoS Genetics, Vol 10, Iss 9, p e1004577 (2014)

Cilia are highly conserved microtubule-based structures that perform a variety of sensory and motility functions during development and adult homeostasis. In humans, defects specifically affecting motile cilia lead to chronic airway infections, infer

Externí odkaz: https://doaj.org/article/221a47d3cc01479e8e83de40453586ea

The Drosophila orthologue of the primary ciliary dyskinesia-associated gene, DNAAF3, is required for axonemal dynein assembly

Autor: Alex von Kriegsheim, Andrew P. Jarman, Iain Hunter, Wai Kit Chan, Alfonso Bolado Carrancio, Petra zur Lage, Jennifer Lennon, Zhiyan Xi

Publikováno v: Biology Open
article-version (VoR) Version of Record
Biology Open, Vol 10, Iss 10 (2021)

Ciliary motility is powered by a suite of highly conserved axoneme-specific dynein motor complexes. In humans, the impairment of these motors through mutation results in the disease primary ciliary dyskinesia (PCD). Studies in Drosophila have helped

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3cc1de59df7f45ceedadbd9710e5fc3
https://doi.org/10.1242/bio.058812

ZMYND10 functions in a chaperone relay during axonemal dynein assembly

Autor: Girish R Mali, Patricia L Yeyati, Seiya Mizuno, Daniel O Dodd, Peter A Tennant, Margaret A Keighren, Petra zur Lage, Amelia Shoemark, Amaya Garcia-Munoz, Atsuko Shimada, Hiroyuki Takeda, Frank Edlich, Satoru Takahashi, Alex von Kreigsheim, Andrew P Jarman, Pleasantine Mill

Publikováno v: eLife
Mali, G R, Yeyati, P L, Mizuno, S, Dodd, D O, Tennant, P A, Keighren, M A, Zur Lage, P, Shoemark, A, Garcia-Munoz, A, Shimada, A, Takeda, H, Edlich, F, Takahashi, S, von Kreigsheim, A, Jarman, A P & Mill, P 2018, ' ZMYND10 functions in a chaperone relay during axonemal dynein assembly ', eLife, vol. 7, e34389 . https://doi.org/10.7554/eLife.34389
eLife, Vol 7 (2018)
Mali, G R, Yeyati, P L, Mizuno, S, Dodd, D O, Tennant, P A, Keighren, M A, zur Lage, P, Shoemark, A, Garcia-Munoz, A, Shimada, A, Takeda, H, Edlich, F, Takahashi, S, von Kreigsheim, A, Jarman, A P & Mill, P 2018, ' ZMYND10 functions in a chaperone relay during axonemal dynein assembly ', eLIFE, vol. 7, e34389 . https://doi.org/10.7554/eLife.34389

Molecular chaperones promote the folding and macromolecular assembly of a diverse set of ‘client’ proteins. How ubiquitous chaperone machineries direct their activities towards specific sets of substrates is unclear. Through the use of mouse gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::fe9afdf204c3777902853e0c311205d4
https://pubmed.ncbi.nlm.nih.gov/29916806