Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Petra Wilgenbus"'
Autor:
Eva-Maria Schweikert, Julianna Amort, Petra Wilgenbus, Ulrich Förstermann, John F. Teiber, Sven Horke
Publikováno v:
Journal of Lipids, Vol 2012 (2012)
The pathogen Pseudomonas aeruginosa causes serious damage in immunocompromised patients by secretion of various virulence factors, among them the quorum sensing N-(3-oxododecanoyl)-L-homoserine lactone (3OC12) and the redox-active pyocyanin (PCN). Pa
Externí odkaz:
https://doaj.org/article/867c52dc95aa47f198b75bc72048e70b
Autor:
Lisa Spiecker, Kerstin Jurk, Wolfram Ruf, John F. Teiber, Sven Horke, Kathrin Schwierczek, Petra Wilgenbus, Huige Li, Julia Ebert, Mareike Döhrmann, Ning Xia
Publikováno v:
Blood. 131:2161-2172
Oxidative stress and inflammation of the vessel wall contribute to prothrombotic states. The antioxidative protein paraoxonase-2 (PON2) shows reduced expression in human atherosclerotic plaques and endothelial cells in particular. Supporting a direct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e39bb362dc19a04d69821d7c77d821
https://doi.org/10.1182/blood-2017-09-807040
https://doi.org/10.1182/blood-2017-09-807040
Autor:
Sven Pagel, Sabine Reyda, Wolfram Ruf, Jennifer Pott, Claudine Graf, Maki Kitano, Stephan Macher-Göppinger, Petra Wilgenbus, Federico Marini, Hartmut Weiler
Immune evasion in the tumor microenvironment (TME) is a crucial barrier for effective cancer therapy, and plasticity of innate immune cells may contribute to failures of targeted immunotherapies. Here, we show that rivaroxaban, a direct inhibitor of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57704dbb2b2a71b8a21b7c1b546190cf
https://europepmc.org/articles/PMC6830514/
https://europepmc.org/articles/PMC6830514/
Autor:
Johanna P. Helmstädter, Julia Ebert, Irina Grechowa, Julianna Amort, Maximilian Krüger, Ines Witte, Maximilian Moergel, Petra Wilgenbus, Stefan Tenzer, Sven Horke
Publikováno v:
Oncotarget
Aberrant Wnt signaling and control of anti-apoptotic mechanisms are pivotal features in different types of cancer to undergo cell death programs. The intracellular human enzyme Paraoxonase-2 (PON2) is known to have anti-apoptotic properties in leukem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5246380967e09658c9f463c2a809ae3d
http://europepmc.org/articles/PMC5239460
http://europepmc.org/articles/PMC5239460
Publikováno v:
Blood. 132:135-135
Coagulation signaling through protease activated receptors (PARs) participates in inflammation and immunity. In cancer, tissue factor (TF) driven signaling via PAR2 promotes tumor progression, but effective pharmacological strategies to inhibit the P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58e92942efe122d31ece19b01e1aa816
https://doi.org/10.1182/blood-2018-99-119167
https://doi.org/10.1182/blood-2018-99-119167
Autor:
Sebastian Altenhöfer, Albrecht M. Clement, John F. Teiber, Sven Horke, Heidrun Witan, Andrea Pautz, Ulrich Förstermann, Petra Wilgenbus, Ines Witte, Andreas Daiber, Huige Li
Publikováno v:
Journal of Biological Chemistry. 285:24398-24403
The human enzyme paraoxonase-2 (PON2) has two functions, an enzymatic lactonase activity and the reduction of intracellular oxidative stress. As a lactonase, it dominantly hydrolyzes bacterial signaling molecule 3OC12 and may contribute to the defens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8030f93a02da0ed78e7d2a30b90879a
https://doi.org/10.1074/jbc.m110.118604
https://doi.org/10.1074/jbc.m110.118604
Autor:
Petra Wilgenbus, Marion Goldeck, Sebastian Altenhöfer, Puneet K. Chowdhary, John F. Teiber, Donovan C. Haines, Gerald L. Kramer, Ulrich Förstermann, Junhui Xiao, Ines Witte, Sven Horke, Robert W. Haley
Publikováno v:
Biochemical Journal. 426:73-83
Two virulence factors produced by Pseudomonas aeruginosa are pyocyanin and N-(3-oxododecanoyl)-L-homoserine lactone (3OC12). Pyocyanin damages host cells by generating ROS (reactive oxygen species). 3OC12 is a quorum-sensing signalling molecule which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::206d10d978497689f536e29f509a357e
https://doi.org/10.1042/bj20091414
https://doi.org/10.1042/bj20091414
Autor:
Maximilian Krüger, Huige Li, Ines Witte, Sven Horke, Petra Wilgenbus, Sebastian Altenhöfer, Ulrich Förstermann
Publikováno v:
Biochemical Journal. 416:395-405
PON2 (paraoxonase-2) is a ubiquitously expressed antioxidative protein which is largely found in the ER (endoplasmic reticulum). Addressing the cytoprotective functions of PON2, we observed that PON2 overexpression provided significant resistance to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9becb4a09c0bb634c1828cd50b0e15ea
https://doi.org/10.1042/bj20080775
https://doi.org/10.1042/bj20080775
Autor:
Ines Witte, Maximilian Krüger, Petra Wilgenbus, Sven Horke, Ulrich Förstermann, Dennis Strand
Publikováno v:
Circulation. 115:2055-2064
Background— In the vascular system, elevated levels of reactive oxygen species (ROS) produce oxidative stress and predispose to the development of atherosclerosis. Therefore, it is important to understand the systems producing and those scavenging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ea1dbf708813908d47d6e82f4202d87
https://doi.org/10.1161/circulationaha.106.681700
https://doi.org/10.1161/circulationaha.106.681700
Autor:
Ines Witte, Eva Schütz, Moritz Selbach, Gerald L. Kramer, Sven Horke, John F. Teiber, Junhui Xiao, Petra Wilgenbus
Pseudomonas aeruginosa produces N -(3-oxo-dodecanoyl)- l -homoserine lactone (3OC12), a crucial signaling molecule that elicits diverse biological responses in host cells thought to subvert immune defenses. The mechanism mediating many of these respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97c0a8cf10fbb7252dadf9240af9e44b
https://europepmc.org/articles/PMC4534671/
https://europepmc.org/articles/PMC4534671/