Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Petra W. van Duijn"'
Autor:
Hanneke Korsten, Angelique C J Ziel-van der Made, Wytske M van Weerden, Theo van der Kwast, Jan Trapman, Petra W Van Duijn
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147500 (2016)
Previously, we generated a preclinical mouse prostate tumor model based on PSA-Cre driven inactivation of Pten. In this model homogeneous hyperplastic prostates (4-5m) developed at older age (>10m) into tumors. Here, we describe the molecular and his
Externí odkaz:
https://doaj.org/article/04529b4168a7415d832f1d571e13be43
Autor:
Emmy W. Verschuren, Katja Närhi, Jenni Lahtela, Simon Anders, Annabrita Hemmes, Jan Trapman, Antti Rannikko, Jari Räsänen, Nina Linder, Riku Turkki, Ashwini S. Nagaraj, Johan Lundin, Kaisa Salmenkivi, Wolfgang Sommergruber, Mikko I. Mäyränpää, Petra W van Duijn, Taija af Hällström, Virva Uotinen, Elina Parri, Olli Kallioniemi
Publikováno v:
The Journal of Pathology. 245:101-113
A key question in precision medicine is how functional heterogeneity in solid tumours informs therapeutic sensitivity. We demonstrate that spatial characteristics of oncogenic signalling and therapy response can be modelled in precision-cut slices fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f65017437957ddde284d19983379b3d4
https://doi.org/10.1002/path.5059
https://doi.org/10.1002/path.5059
Autor:
Petra W van Duijn, Cor A. Berrevoets, Angelique C.J. Ziel-van der Made, Ashraf Aghai, Wytske M. van Weerden, Guido Jenster, Rute B. Marques, Jan Trapman, Reno Debets, Hanneke J. A. A. van Zoggel
Publikováno v:
Prostate, 78(13), 1013-1023. Wiley-Liss Inc.
Background Prostate cancer is recognized as a heterogeneous disease demanding appropriate preclinical models that reflect tumor complexity. Previously, we established the PSA-Cre;PtenLoxP/LoxP genetic engineered mouse model (GEMM) for prostate cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1aa427d28d0ad67f423dd911ea02dd6
https://doi.org/10.1002/pros.23659
https://doi.org/10.1002/pros.23659
Autor:
Wolfgang Sommergruber, Riku Turkki, Mikko I. Mäyränpää, Olli Kallioniemi, Katja Närhi, Jenni Lahtela, Virva Uotinen, Emmy W. Verschuren, Annabrita Hemmes, Taija af Hällström, Simon Anders, Antti Rannikko, Jari Räsänen, Nina Linder, Ashwini S. Nagaraj, Petra W van Duijn, Kaisa Salmenkivi, Elina Parri, Jan Trapman, Johan Lundin
Publikováno v:
Journal of Pathology, 245(1), 101-113. John Wiley & Sons Ltd.
The Journal of Pathology
The Journal of Pathology
A key question in precision medicine is how functional heterogeneity in solid tumours informs therapeutic sensitivity. We demonstrate that spatial characteristics of oncogenic signalling and therapy response can be modelled in precision-cut slices fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f766be33f2ab7f68d5121725cb9d845
http://hdl.handle.net/10138/333759
http://hdl.handle.net/10138/333759
Autor:
J. Trapman, Petra W. van Duijn
Publikováno v:
The Prostate. 66:749-760
BACKGROUND We compared the involvement of PI3K/PTEN/Akt signaling in the regulation of the cell-cycle regulator p27kip1 and investigated the mechanism of PI3K/PTEN/Akt modulation of p27kip1 in the prostate cancer cell lines LNCaP, PC346, PC3, and DU1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c1feed024647303b1b568d8443f78d
https://doi.org/10.1002/pros.20398
https://doi.org/10.1002/pros.20398
Autor:
Marcel Vermeij, Angelique C.J. Ziel-van der Made, Jan Trapman, Kitty B.J.M. Cleutjens, Paul Krimpenfort, Hetty A. G. M. van der Korput, Binha Autar, Ronald R. de Krijger, Anton Berns, Petra W van Duijn, Theo H. van der Kwast, Xiaoqian Ma
Publikováno v:
Cancer Research, 65(13), 5730-5739. American Association for Cancer Research Inc.
The PTEN tumor suppressor gene is frequently inactivated in human tumors, including prostate cancer. Based on the Cre/loxP system, we generated a novel mouse prostate cancer model by targeted inactivation of the Pten gene. In this model, Cre recombin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6dee8e32610779d12100c210fe6bee7
https://doi.org/10.1158/0008-5472.can-04-4519
https://doi.org/10.1158/0008-5472.can-04-4519
Autor:
Petra W van Duijn, Jan Trapman, Angelique C.J. Ziel-van der Made, Hanneke Korsten, Wytske M. van Weerden, Theo H. van der Kwast
Publikováno v:
PLoS One (print), 11(1):e0147500. Public Library of Science
PLoS ONE
PLoS ONE, Vol 11, Iss 1, p e0147500 (2016)
PLoS ONE
PLoS ONE, Vol 11, Iss 1, p e0147500 (2016)
Previously, we generated a preclinical mouse prostate tumor model based on PSA-Cre driven inactivation of Pten. In this model homogeneous hyperplastic prostates (4-5m) developed at older age (>10m) into tumors. Here, we describe the molecular and his
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23769c2d05cca2e8890d463aba6fff12
https://doi.org/10.1371/journal.pone.0147500
https://doi.org/10.1371/journal.pone.0147500