Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Petra U. Prinz"'
Autor:
Melissa Maxwell, James Cardia, Mani Kadiyala, Elfriede Noessner, Petra U. Prinz, Dingxue Yan, Anna Herbstritt, Simon Fricker
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Although present in high numbers, T and NK cells appear functionally impaired in the renal cell carcinoma (RCC) tumor milieu, as they cannot be stimulated to degranulation and IFN-γ production. This is in part due to altered regulation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d2c2ae11be826d3e0337ce2d61e6003
https://doi.org/10.1136/jitc-2020-sitc2020.0599
https://doi.org/10.1136/jitc-2020-sitc2020.0599
Autor:
Melissa Maxwell, Mani Kadiyala, AS Herbstritt, Petra U. Prinz, Dingxue Yan, Elfriede Noessner
Publikováno v:
E-Poster Presentations.
Background T and NK cells from human renal cell carcinoma (RCC) are functionally non-responsive. Analysis of the TCR signaling cascade required for effector function identified that proximal signaling molecules were activated whereas activation of do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1ea487640ce29e51f4718b7c5097d42
https://doi.org/10.1136/jitc-2020-itoc7.21
https://doi.org/10.1136/jitc-2020-itoc7.21
Autor:
Elfriede Noessner, Ralph Oberneder, Dorothee Brech, Anna N. Mendler, Petra U. Prinz, Ilias Masouris
Publikováno v:
International Journal of Cancer. 135:1832-1841
The relevance of NK cells in tumor control is well established in mouse models and human hematologic malignancies; however, their contribution to the control of human solid tumors remains disputed due to problems with in situ detection and reports of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d276ec06800f359d6b483a0d450bd2d
https://doi.org/10.1002/ijc.28837
https://doi.org/10.1002/ijc.28837
Autor:
Ilias Masouris, Petra U. Prinz, Elfriede Noessner, Ralph Oberneder, Leopold Durner, Anna N. Mendler
Publikováno v:
J. Immunol. 188, 5990-6000 (2012)
CD8+ tumor-infiltrating T cells (CD8-TILs) are found in many types of tumors including human renal cell carcinoma. However, tumor rejection rarely occurs, suggesting limited functional activity in the tumor microenvironment. In this study, we documen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04844889c4e3eb63670dfef6f239a6e
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=7569
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=7569
Autor:
Rainer Riesenberg, Elfriede Noessner, Robert Kammerer, Alexander Buchner, Peter J. Nelson, Petra U. Prinz, Sabine Siegert, Judith Eckl
Publikováno v:
J. Mol. Med. 90, 55-66 (2012)
Clear cell renal cell carcinoma (ccRCC) is an aggressive and difficult to manage cancer. Immunotherapy has the potential to induce long-lasting regression in a small group of patients. However, severe side effects limit broad application which highli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0346609684f260c248d17add074fe2dd
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=7134
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=7134
Publikováno v:
Int. J. Cancer 131, 633-640 (2012)
Lactic acidosis is common to most solid tumors and has been found to affect infiltrating immune cells. Here we document effector phase inhibition of cytotoxic T cells (CTLs) involving complete blockage of cytokine production and partial impairment of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cefd153805d1019176259544d6f1180
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=6619
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=6619
Autor:
Niklas Muenchmeier, Nicole Rieth, Petra U. Prinz, David Anz, Ainhoa-M. Figel, Peter J. Nelson, Alexander Buchner, Stefan Porubsky, Judith Eckl, Ulrike K. Lettenmeyer, Adriana Turqueti-Neves, Elfriede Noessner, Stephan Segerer, Josef Mysliwietz, Sabine Siegert, Dorothee Brech
Publikováno v:
AMERICAN JOURNAL OF PATHOLOGY
Am. J. Pathol. 179, 436-451 (2011)
Am. J. Pathol. 179, 436-451 (2011)
Tissue dendritic cells (DCs) may influence the progression of renal cell carcinoma (RCC) by regulating the functional capacity of antitumor effector cells. DCs and their interaction with T cells were analyzed in human RCC and control kidney tissues.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9f42f629dbf5bca058d2bb30a417063
https://doi.org/10.5167/uzh-53895
https://doi.org/10.5167/uzh-53895