Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Petra Simic"'
Autor:
Petra Simic
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Purpose of review: Mineral and bone disorder (MBD) is a prevalent complication in chronic kidney disease (CKD), significantly impacting overall health with multifaceted implications including fractures, cardiovascular events, and mortality. Despite i
Externí odkaz:
https://doaj.org/article/a3b8a68b2d4d483987b27c61fa643d7c
Autor:
Han Xie, Isinsu Bastepe, Wen Zhou, Birol Ay, Zara Ceraj, Ignacio A. Portales-Castillo, Eva S. Liu, Sherri-Ann M. Burnett-Bowie, Harald Jüppner, Eugene P. Rhee, Murat Bastepe, Petra Simic
Publikováno v:
JCI Insight, Vol 8, Iss 17 (2023)
Intact fibroblast growth factor 23 (iFGF23) is a phosphaturic hormone that is cleaved by furin into N-terminal and C-terminal fragments. Several studies have implicated vitamin D in regulating furin in infections. Thus, we investigated the effect of
Externí odkaz:
https://doaj.org/article/b06b80cae0e94772ab23ca6c29508e95
Autor:
Wen Zhou, Petra Simic, Iris Y. Zhou, Peter Caravan, Xavier Vela Parada, Donghai Wen, Onica L. Washington, Maria Shvedova, Kerry A. Pierce, Clary B. Clish, Michael Mannstadt, Tatsuya Kobayashi, Marc N. Wein, Harald Jüppner, Eugene P. Rhee
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 8 (2023)
How phosphate levels are detected in mammals is unknown. The bone-derived hormone fibroblast growth factor 23 (FGF23) lowers blood phosphate levels by reducing kidney phosphate reabsorption and 1,25(OH)2D production, but phosphate does not directly s
Externí odkaz:
https://doaj.org/article/e89541dfb86a4e3cba30439d498ee8eb
Autor:
Ignacio Portales-Castillo, Petra Simic
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
The actions of several bone-mineral ion regulators, namely PTH, FGF23, Klotho and 1,25(OH)2 vitamin D (1,25(OH)2D), control calcium and phosphate metabolism, and each of these molecules has additional biological effects related to cell signaling, met
Externí odkaz:
https://doaj.org/article/93f9af770daa40568a2fc91189600dca
Autor:
Petra Simic, Xavier Fernando Vela Parada, Samir M. Parikh, Ryan Dellinger, Leonard P. Guarente, Eugene P. Rhee
Publikováno v:
BMC Nephrology, Vol 21, Iss 1, Pp 1-9 (2020)
Abstract Background Preclinical studies have identified both NAD+ and sirtuin augmentation as potential strategies for the prevention and treatment of AKI. Nicotinamide riboside (NR) is a NAD+ precursor vitamin and pterostilbene (PT) is potent sirtui
Externí odkaz:
https://doaj.org/article/cb64e9305f5947d394fce6f6124b03d6
Autor:
Petra Simic, Eric O. Williams, Eric L. Bell, Jing Jing Gong, Michael Bonkowski, Leonard Guarente
Publikováno v:
Cell Reports, Vol 3, Iss 4, Pp 1175-1186 (2013)
The epithelial-to-mesenchymal transition (EMT) is important for the development of cancer metastases and organ fibrosis, conditions prevalent in aging. Because sirtuins affect the pathology of aging, we tested the effect of SirT1 on EMT. Reduced SIRT
Externí odkaz:
https://doaj.org/article/73d53392cf324778b58da00d7df77e7c
Autor:
Petra Simic, Kayvan Zainabadi, Eric Bell, David B. Sykes, Borja Saez, Sutada Lotinun, Roland Baron, David Scadden, Ernestina Schipani, Leonard Guarente
Publikováno v:
EMBO Molecular Medicine, Vol 5, Iss 3, Pp 430-440 (2013)
Abstract Mesenchymal stem cells (MSCs) are multi‐potent cells that can differentiate into osteoblasts, adipocytes, chondrocytes and myocytes. This potential declines with aging. We investigated whether the sirtuin SIRT1 had a function in MSCs by cr
Externí odkaz:
https://doaj.org/article/d6fce7dc458e4c2090ba9165d4886d3d
Autor:
Petra Simic, Kayvan Zainabadi, Eric Bell, David B. Sykes, Borja Saez, Sutada Lotinun, Roland Baron, David Scadden, Ernestina Schipani, Leonard Guarente
Publikováno v:
EMBO Molecular Medicine, Vol 5, Iss 3, Pp 482-482 (2013)
Externí odkaz:
https://doaj.org/article/3a011196ed9441b88abf021164dde0b1
Autor:
Jodie L. Babitt, Petra Simic
Publikováno v:
Curr Osteoporos Rep
PURPOSE OF REVIEW: Fibroblast growth factor-23 (FGF23) is a bone- and bone marrow-derived hormone that is critical to maintain phosphate homeostasis. The principal actions of FGF23 are to reduce serum phosphate levels by decreasing kidney phosphate r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5340d585dea23937a3b65d232c574d1e
https://doi.org/10.1007/s11914-021-00703-w
https://doi.org/10.1007/s11914-021-00703-w
Publikováno v:
Nephron
Elevated fibroblast growth factor 23 (FGF23) levels are markers and potential mediators, of adverse outcomes in acute kidney injury (AKI). We recently identified glycerol-3-phosphate (G-3-P), a glycolysis byproduct, as a kidney-derived factor that ci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e6b8410de1625fd2d19baca5434e466
https://doi.org/10.1159/000517734
https://doi.org/10.1159/000517734