Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Petra Selchow"'
Autor:
Katja Becker, Klara Haldimann, Petra Selchow, Lukas M. Reinau, Michael Dal Molin, Peter Sander
Publikováno v:
Frontiers in Microbiology, Vol 8 (2017)
Lipoproteins are important components of the mycobacterial cell envelope due to their function in cell wall homeostasis and bacterial virulence. They are post-translationally modified with lipid- and glycosyl-residues in various species and interfere
Externí odkaz:
https://doaj.org/article/864df716021b41f4a0ef19c308d7bd62
Autor:
Petra Selchow, Diane J. Ordway, Deepshikha Verma, Nicholas Whittel, Aline Petrig, Sven N. Hobbie, Erik C. Böttger, Peter Sander
Publikováno v:
Antimicrob Agents Chemother
Antibiotic therapy of infections caused by the emerging pathogen Mycobacterium abscessus is challenging due to the organism's inherent resistance to clinically available antimicrobials. The low bactericidal potency of currently available treatment re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::166aa7602af33389f2f20cfe9cc99abb
https://europepmc.org/articles/PMC8846310/
https://europepmc.org/articles/PMC8846310/
Autor:
Barbara Borer, Daniel Schäfle, Peter Sander, Michael Meuli, Anna Rominski, Petra Selchow, Bettina Schulthess
Publikováno v:
Antimicrob Agents Chemother
Mycobacterium abscessus exhibits arr (ADP-ribosyltransferase)-dependent rifampicin (RIF) resistance. In apparent contrast, rifabutin (RBT) has demonstrated promising activity in M. abscessus infection models implying that RBT might not be inactivated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::503e754debd19d472362dceb7e873830
https://europepmc.org/articles/PMC8092531/
https://europepmc.org/articles/PMC8092531/
Autor:
Sakshi Luthra, Aron Gagliardi, Daniel Schäfle, Peter Sander, Bettina Schulthess, Petra Selchow
Publikováno v:
Antimicrob Agents Chemother
Isoniazid (INH) is a cornerstone of antitubercular therapy. Mycobacterium tuberculosis complex bacteria are the only mycobacteria sensitive to clinically relevant concentrations of INH. All other mycobacteria, including M. marinum and M. avium subsp.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1102569a72ccde17372caab035c30af6
https://europepmc.org/articles/PMC7179591/
https://europepmc.org/articles/PMC7179591/
Autor:
Ulrich Matt, Annelies S. Zinkernagel, Peter Sander, O. Sharif, Katrin Schilcher, A. Stenzinger, Sabine Strommer, Johannes Nemeth, Petra Selchow, M. Dal Molin, Markus Zeitlinger, Federica Andreoni
Publikováno v:
International Journal of Antimicrobial Agents. 50:55-62
Mycobacterium tuberculosis (MTB) is notorious for persisting within host macrophages. Efflux pumps decrease intracellular drug levels, thus fostering persistence of MTB during therapy. Isoniazid (INH) and pyrazinamide (PZA) are substrates of the effl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e06a62a792023cf333a9f5c564baa64
https://doi.org/10.1016/j.ijantimicag.2017.02.022
https://doi.org/10.1016/j.ijantimicag.2017.02.022
Autor:
Stephan Laage-Witt, Andreas Tschumi, Daniel Schäfle, Peter Sander, Michael Dal Molin, Thomas Ryckmans, Petra Selchow
Drug resistance in Mycobacterium tuberculosis is relentlessly progressing while only a handful of novel drug candidates are developed. Here we describe a GFP-based high-throughput screening of 386,496 diverse compounds to identify putative tuberculos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8dfbf23f948338c9b54a3b828c55b56
https://doi.org/10.5167/uzh-177726
https://doi.org/10.5167/uzh-177726
Publikováno v:
J. Antimicrob. Chemother.
Objectives Rifampicin, a potent first-line TB drug of the rifamycin group, shows only little activity against the emerging pathogen Mycobacterium abscessus. Reportedly, bacterial resistance to rifampicin is associated with polymorphisms in the target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b23a509e7e1e51f92851c5f7a3e41f2c
Autor:
Annelies S. Zinkernagel, Peter Sander, Petra Selchow, A. Stenzinger, Sabine Strommer, M. Dal Molin, Markus Zeitlinger, Katrin Schilcher, Federica Andreoni, Ulrich Matt, Omar Sharif, Johannes Nemeth
Publikováno v:
International journal of antimicrobial agents. 51(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43c8cc92b8a57619355d6d7641c194c1
https://pubmed.ncbi.nlm.nih.gov/28506804
https://pubmed.ncbi.nlm.nih.gov/28506804
Autor:
Davide Deodato, Davide M. Ferraris, Peter Sander, Petra Selchow, Maurizio Botta, Menico Rizzi, Mattia Mori, Francesca Moraca
Publikováno v:
Bioorganic & Medicinal Chemistry Letters; Vol 24
Bioorganic & Medicinal Chemistry Letters
Bioorganic & Medicinal Chemistry Letters
The Mycobacterium tuberculosis extracellular zinc metalloprotease 1 (Zmp1) has been proposed to play a key role in phagosome maturation and to enhance the survival of Mycobacterium tuberculosis in the host. Consequently, small molecule inhibitors of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aed6a39f47fb14be2d83f86ba64cc2d
Autor:
Peter Sander, Michael Dal Molin, Juliane K. Brülle, Anna Rominski, Petra Selchow, Katja Becker
Publikováno v:
J. Antimicrob. Chemother.
Objectives: Mycobacterium abscessus is innately resistant towards a variety of drugs thereby limiting therapeutic options. Bacterial resistance towards aminoglycosides (AGs) mainly is conferred by AG modifying enzymes which often have overlapping act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5413b8848bfb67ef6cb96a9362834e61
https://pubmed.ncbi.nlm.nih.gov/28486671
https://pubmed.ncbi.nlm.nih.gov/28486671