Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Petra S. Bachmann"'
Autor:
Richard B. Lock, Glenn M. Marshall, Ursula R. Kees, Jette Ford, Jane E. Bardell, Rachael A. Papa, Rosemary Gorman, Petra S. Bachmann
Supplementary Figure 1 from Divergent Mechanisms of Glucocorticoid Resistance in Experimental Models of Pediatric Acute Lymphoblastic Leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42c4aec69f68e94064be16f7792368c0
https://doi.org/10.1158/0008-5472.22370843.v1
https://doi.org/10.1158/0008-5472.22370843.v1
Autor:
Richard B. Lock, Glenn M. Marshall, Ursula R. Kees, Jette Ford, Jane E. Bardell, Rachael A. Papa, Rosemary Gorman, Petra S. Bachmann
Cell line models of glucocorticoid resistance in childhood acute lymphoblastic leukemia (ALL) almost invariably exhibit altered glucocorticoid receptor (GR) function. However, these findings are incongruous with those using specimens derived directly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09bad29eb189daaa78c85badd3d4a2ab
https://doi.org/10.1158/0008-5472.c.6496553
https://doi.org/10.1158/0008-5472.c.6496553
Autor:
Rocco Piazza, Vera Magistroni, Angela Mogavero, Federica Andreoni, Chiara Ambrogio, Roberto Chiarle, Luca Mologni, Petra S Bachmann, Richard B Lock, Paola Collini, Giuseppe Pelosi, Carlo Gambacorti-Passerini
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 5, Pp 511-522 (2013)
BIM is a proapoptotic member of the Bcl-2 family. Here, we investigated the epigenetic status of the BIM locus in NPM/ALK+ anaplastic large cell lymphoma (ALCL) cell lines and in lymph node biopsies from NPM/ALK+ ALCL patients. We show that BIM is ep
Externí odkaz:
https://doaj.org/article/03b409ae70454479a9d66bf43e7da19e
Autor:
Andrea Biondi, Barbara Szymanska, Petra S. Bachmann, Glenn M. Marshall, Vera Magistroni, Greta Geninson, Angela Mogavero, Berthold Göttgens, Richard Saffery, Rocco Piazza, Richard B. Lock, Nicholas C. Wong, Mary E. Janes, Vivek A Bhadri, Diego Miranda-Saavedra, John E. Pimanda, Giovanni Cazzaniga, Carlo Gambacorti-Passerini, Carwyn Davies, Jeffrey M. Craig
Publikováno v:
Blood. 116:3013-3022
Glucocorticoids play a critical role in the therapy of lymphoid malignancies, including pediatric acute lymphoblastic leukemia (ALL), although the mechanisms underlying cellular resistance remain unclear. We report glucocorticoid resistance attributa
Autor:
Richard B. Lock, Petra S. Bachmann
Publikováno v:
Current Drug Targets. 8:773-783
The number of new anti-cancer drugs emerging for clinical trials in humans far exceeds the availability of pediatric acute leukemia patients to be entered into clinical trials. Therefore, preclinical testing of new agents for the treatment of childho
Publikováno v:
Blood. 105:2519-2526
Glucocorticoids are among the most effective agents used in the treatment of childhood acute lymphoblastic leukemia (ALL), and patient response to treatment is an important determinant of long-term outcome. Despite its clinical significance, the mole
Autor:
Petra S. Bachmann, Richard B. Lock, Jette Ford, Rachael A. Papa, Glenn M. Marshall, Rosemary Gorman, Jane E. Bardell, Ursula R. Kees
Publikováno v:
Cancer research. 67(9)
Cell line models of glucocorticoid resistance in childhood acute lymphoblastic leukemia (ALL) almost invariably exhibit altered glucocorticoid receptor (GR) function. However, these findings are incongruous with those using specimens derived directly
Publikováno v:
Leukemialymphoma. 48(4)
Major advances in understanding the pathophysiology of acute leukemia have resulted in a dramatic increase in the availability of novel compounds for clinical trials. However, since the number of new drugs far exceeds the number of clinical trials th
Autor:
Vera Magistroni, Rocco Piazza, Angela Mogavero, Richard B. Lock, Luca Mologni, Roberto Chiarle, Carlo Gambacorti-Passerini, Petra S. Bachmann, Chiara Ambrogio, Giuseppe Pelosi, Federica Andreoni, Paola Collini
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 5, Pp 511-522 (2013)
BIM is a proapoptotic member of the Bcl-2 family. Here, we investigated the epigenetic status of the BIM locus in NPM/ALK+ anaplastic large cell lymphoma (ALCL) cell lines and in lymph node biopsies from NPM/ALK+ ALCL patients. We show that BIM is ep
Autor:
Jeffrey M. Craig, Nicholas C. Wong, Richard B. Lock, John E. Pimanda, Vera Magistroni, Carwyn Davies, Richard Saffery, Angela Mogavero, Mary James, Vivek A Bhadri, Glenn M. Marshall, Rocco Piazza, Carlo Gambacorti-Passerini, Petra S. Bachmann
Publikováno v:
Blood. 114:939-939
Abstract 939 Introduction: The glucocorticoids dexamethasone and prednisolone are critical components of combination chemotherapy regimens used to treat pediatric acute lymphoblastic leukemia (ALL). While approximately 80% of patients are cured, poor