Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Petra Rueger"'
Autor:
Felix Weber, Bernd Bohrmann, Jens Niewoehner, Jens A.A. Fischer, Petra Rueger, Georg Tiefenthaler, Joerg Moelleken, Alexander Bujotzek, Kevin Brady, Thomas Singer, Martin Ebeling, Antonio Iglesias, Per-Ola Freskgård
Publikováno v:
Cell Reports, Vol 22, Iss 1, Pp 149-162 (2018)
Summary: Receptors show promise for the transport of monoclonal antibodies (mAbs) across the blood-brain barrier. However, safety liabilities associated with peripheral receptor binding and Fc effector function have been reported. We present the Brai
Externí odkaz:
https://doaj.org/article/cfcea31f527746b2b77e3b13637c56eb
Autor:
Tetyana Dashivets, Marco Thomann, Petra Rueger, Alexander Knaupp, Johannes Buchner, Tilman Schlothauer
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0143520 (2015)
Therapeutic performance of recombinant antibodies relies on two independent mechanisms: antigen recognition and Fc-mediated antibody effector functions. Interaction of Fc-fragment with different FcR triggers antibody-dependent cellular cytotoxicity a
Externí odkaz:
https://doaj.org/article/3fed091754384dec8a0d04e6fc49c565
Autor:
Peter Sondermann, Anne Freimoser–Grundschober, Pablo Umana, Felix Fingas, Sylvia Herter, Petra Rueger, Tilman Schlothauer, Christiane Neumann
Publikováno v:
Journal of chromatography. A. 1610
Therapeutic antibodies can elicit an immune response through different mechanisms, either cell independent via complement activation (CDC) or through activation of immune-effector cells (such as macrophages and NK cells). After target binding, the Fc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da884f0e0b1206a173a0b63ca7d33dc5
https://pubmed.ncbi.nlm.nih.gov/31597603
https://pubmed.ncbi.nlm.nih.gov/31597603
Autor:
Antonio Iglesias, Jens Niewoehner, Jens Fischer, Bernd Bohrmann, Alexander Bujotzek, Joerg Moelleken, Felix C. Weber, Thomas Singer, Georg Tiefenthaler, Martin Ebeling, Kevin Brady, Petra Rueger, Per-Ola Freskgard
Publikováno v:
Cell Reports, Vol 22, Iss 1, Pp 149-162 (2018)
Summary: Receptors show promise for the transport of monoclonal antibodies (mAbs) across the blood-brain barrier. However, safety liabilities associated with peripheral receptor binding and Fc effector function have been reported. We present the Brai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f91add0e98b7fb6fd2eb88b6b6b260
https://pubmed.ncbi.nlm.nih.gov/29298417
https://pubmed.ncbi.nlm.nih.gov/29298417
Autor:
Ulrike Reiff, Alexander Knaupp, Hubert Hertenberger, Lothar Kling, Andreas Wolfert, Petra Rueger, Christian Spick, Georg Drabner, Jan Olaf Stracke, Hans Koll, Thomas Emrich, Wilma Lau, Tilman Schlothauer, Apollon Papadimitriou
Publikováno v:
mAbs
Preserving the chemical and structural integrity of therapeutic antibodies during manufacturing and storage is a major challenge during pharmaceutical development. Oxidation of Fc methionines Met252 and Met428 is frequently observed, which leads to r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4fd155c1a4fa90162b31bf404998258
https://doi.org/10.4161/mabs.29601
https://doi.org/10.4161/mabs.29601
Autor:
Victoria Walker, Andrew E. Boyd, Justin Warne, Matthias Rueth, Wolfgang von der Saal, Richard W Marston, Frederick Arthur Brookfield, Stephen Martin Courtney, Anja Limberg, Michael Prime, Bernhard Goller, Petra Rueger, Richard A. Engh, Norman Kairies, Guy Georges
Publikováno v:
Journal of Medicinal Chemistry. 54:312-319
The inhibition of Aurora kinases in order to arrest mitosis and subsequently inhibit tumor growth via apoptosis of proliferating cells has generated significant discussion within the literature. We report a novel class of Aurora kinase inhibitors bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ad902287a2ae582c7edd9d886b2a5b7
https://doi.org/10.1021/jm101346r
https://doi.org/10.1021/jm101346r
Autor:
Johannes Buchner, Tilman Schlothauer, Petra Rueger, Marco Thomann, Alexander Knaupp, Tetyana Dashivets
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 12, p e0143520 (2015)
PLoS ONE, Vol 10, Iss 12, p e0143520 (2015)
Therapeutic performance of recombinant antibodies relies on two independent mechanisms: antigen recognition and Fc-mediated antibody effector functions. Interaction of Fc-fragment with different FcR triggers antibody-dependent cellular cytotoxicity a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a7148ba4aeefb9798566640af13efb9
https://doi.org/10.1371/journal.pone.0143520
https://doi.org/10.1371/journal.pone.0143520
Autor:
Rolf D. Schmid, Petra Rueger, Baerbel Beyersdorf-Radeck, Frank F. Bier, Frank Zischkale, Ursula Bilitewski
Publikováno v:
International Conference on Monitoring of Toxic Chemicals and Biomarkers.
Different biosensor systems suitable for the determination of pesticides in water are described. They are based on immobilized biological components, which are sensitive to compounds commonly used as pesticides. The biological components in the work
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa7188b6383b7b37739ff02b7c45dc2a
https://doi.org/10.1117/12.140254
https://doi.org/10.1117/12.140254
Phthalazinone Pyrazoles as Potent, Selective, and Orally Bioavailable Inhibitors of Aurora-A Kinase.
Autor:
Michael E. Prime, Stephen M. Courtney, Frederick A. Brookfield, Richard W. Marston, Victoria Walker, Justin Warne, Andrew E. Boyd, Norman A. Kairies, Wolfgang von der Saal, Anja Limberg, Guy Georges, Richard A. Engh, Bernhard Goller, Petra Rueger, Matthias Rueth
Publikováno v:
Journal of Medicinal Chemistry; Jan2011, Vol. 54 Issue 1, p312-319, 8p
Autor:
Hadassah Sade, Hansruedi Loetscher, Alain Tissot, Jan Olaf Stracke, Per-Ola Freskgard, Petra Rueger, Wilma Lau, Eduard Urich, Peter Maier, Anirvan Ghosh, Jens Niewoehner, Bernd Bohrmann, Ludovic Collin
Publikováno v:
Neuron. (1):49-60
SummaryAlthough biotherapeutics have vast potential for treating brain disorders, their use has been limited due to low exposure across the blood-brain barrier (BBB). We report that by manipulating the binding mode of an antibody fragment to the tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a70428e15b13977e3aa3a9a3a0009ff