Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Petra Pečinková"'
Mixture Effects of Tryptophan Intestinal Microbial Metabolites on Aryl Hydrocarbon Receptor Activity
Autor:
Aneta Vrzalová, Petra Pečinková, Peter Illés, Soňa Gurská, Petr Džubák, Martin Szotkowski, Marián Hajdúch, Sridhar Mani, Zdeněk Dvořák
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10825 (2022)
Aryl hydrocarbon receptor (AHR) plays pivotal roles in intestinal physiology and pathophysiology. Intestinal AHR is activated by numerous dietary, endogenous, and microbial ligands. Whereas the effects of individual compounds on AHR are mostly known,
Externí odkaz:
https://doaj.org/article/bbe414ea573344799271833a751af8dc
Autor:
Barbora Vyhlídalová, Kristýna Krasulová, Petra Pečinková, Karolína Poulíková, Radim Vrzal, Zdeněk Andrysík, Aneesh Chandran, Sridhar Mani, Zdenek Dvorak
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 8, p 2799 (2020)
The efforts for therapeutic targeting of the aryl hydrocarbon receptor (AhR) have emerged in recent years. We investigated the effects of available antimigraine triptan drugs, having an indole core in their structure, on AhR signaling in human hepati
Externí odkaz:
https://doaj.org/article/ac689271d9844133b2b83826c653b209
Autor:
Barbora Vyhlídalová, Kristýna Krasulová, Petra Pečinková, Adéla Marcalíková, Radim Vrzal, Lenka Zemánková, Jan Vančo, Zdeněk Trávníček, Jan Vondráček, Martina Karasová, Sridhar Mani, Zdeněk Dvořák
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 7, p 2614 (2020)
We examined the effects of gut microbial catabolites of tryptophan on the aryl hydrocarbon receptor (AhR). Using a reporter gene assay, we show that all studied catabolites are low-potency agonists of human AhR. The efficacy of catabolites differed s
Externí odkaz:
https://doaj.org/article/04270e0b74804ce4a71a903df1898c26
Autor:
Aneta Grycová, Hansol Joo, Vítězslav Maier, Peter Illés, Barbora Vyhlídalová, Karolína Poulíková, Lucia Sládeková, Petr Nádvorník, Radim Vrzal, Lenka Zemánková, Petra Pečinková, Martin Poruba, Iveta Zapletalová, Rostislav Večeřa, Pavel Anzenbacher, Jiří Ehrmann, Peter Ondra, Jong-Wha Jung, Sridhar Mani, Zdeněk Dvořák
Publikováno v:
Journal of medicinal chemistry. 65(9)
Targeting the aryl hydrocarbon receptor (AhR) is an emerging therapeutic strategy for multiple diseases (e.g., inflammatory bowel disease).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f282e15f7eaad64d30b2eeac93914b7d
https://pubmed.ncbi.nlm.nih.gov/35416668
https://pubmed.ncbi.nlm.nih.gov/35416668
Autor:
Kristýna Krasulová, Karolína Poulíková, Peter Illes, Radim Vrzal, Zdeněk Dvořák, Barbora Vyhlídalová, Petra Pečinková, Natália Sirotová, Sridhar Mani, Adéla Marcalíková
Publikováno v:
Toxicology letters. 334
The interplays between the metabolic products of intestinal microbiota and the host signaling through xenobiotic receptors, including pregnane X receptor (PXR), are of growing interest, in the context of intestinal health and disease. A distinct clas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f757fbe109ee2d231f78fa73373d2943
https://pubmed.ncbi.nlm.nih.gov/33002526
https://pubmed.ncbi.nlm.nih.gov/33002526
Autor:
Adéla Marcalíková, Lenka Zemánková, Jan Vondráček, Kristýna Krasulová, Martina Karasová, Radim Vrzal, Zdeněk Dvořák, Zdeněk Trávníček, Ján Vančo, Barbora Vyhlídalová, Sridhar Mani, Petra Pečinková
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 2614, p 2614 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 7
International Journal of Molecular Sciences
Volume 21
Issue 7
We examined the effects of gut microbial catabolites of tryptophan on the aryl hydrocarbon receptor (AhR). Using a reporter gene assay, we show that all studied catabolites are low-potency agonists of human AhR. The efficacy of catabolites differed s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cd174c5e78e028172bf669dfba26ff7
https://www.mdpi.com/1422-0067/21/7/2614
https://www.mdpi.com/1422-0067/21/7/2614
Autor:
Zdeněk Andrysík, Kristýna Krasulová, Zdenek Dvorak, Aneesh Chandran, Karolína Poulíková, Petra Pečinková, Radim Vrzal, Barbora Vyhlídalová, Sridhar Mani
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 8
International Journal of Molecular Sciences, Vol 21, Iss 2799, p 2799 (2020)
Volume 21
Issue 8
International Journal of Molecular Sciences, Vol 21, Iss 2799, p 2799 (2020)
The efforts for therapeutic targeting of the aryl hydrocarbon receptor (AhR) have emerged in recent years. We investigated the effects of available antimigraine triptan drugs, having an indole core in their structure, on AhR signaling in human hepati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bd0758d7ccc5c780dd4fbcc98a8edd6
https://pubmed.ncbi.nlm.nih.gov/32316498
https://pubmed.ncbi.nlm.nih.gov/32316498
Autor:
Hao Li, Breyen Coffin, Irwin J. Kurland, Weijie Chen, Lars Ulrik Nordstrøm, Vera DesMarais, Kristýna Krasulová, Chamini V. Karunaratne, Wei Dou, Joseph Albanese, Eva Jiskrová, Annie Yang, Dana J. Lukin, Michael Longo, Qiang Liu, Zdeněk Dvořák, Xiaoping Luo, Petra Pečinková, Sridhar Mani, Ashwin Akki, Peter Illes, Yunping Qiu
Publikováno v:
Bioorg Chem
Microbial metabolite mimicry is a new concept that promises to deliver compounds that have minimal liabilities and enhanced therapeutic effects in a host. In a previous publication, we have shown that microbial metabolites of L-tryptophan, indoles, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4cd97504eec6e77711f612b3d779b9c
https://doi.org/10.1016/j.bioorg.2021.104661
https://doi.org/10.1016/j.bioorg.2021.104661
Autor:
Vrzalová, Aneta1 (AUTHOR), Pečinková, Petra1 (AUTHOR), Illés, Peter1 (AUTHOR), Gurská, Soňa2 (AUTHOR), Džubák, Petr2 (AUTHOR), Szotkowski, Martin2 (AUTHOR), Hajdúch, Marián2 (AUTHOR), Mani, Sridhar3 (AUTHOR), Dvořák, Zdeněk1 (AUTHOR) moulin@email.cz
Publikováno v:
International Journal of Molecular Sciences. Sep2022, Vol. 23 Issue 18, pN.PAG-N.PAG. 15p.
Autor:
Díaz, Mariana, Pečinková, Petra, Nowicka, Anna, Baroux, Célia, Sakamoto, Takuya, Gandha, Priscilla Yuliani, Jeřábková, Hana, Matsunaga, Sachihiro, Grossniklaus, Ueli, 1, Ales Pecinka
Publikováno v:
Plant Cell; Jul2019, Vol. 31 Issue 7, p1579-1597, 19p