Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Petra Obexer"'
Autor:
Christina Salvador, Robert Salvador, Gabriele Kropshofer, Bernhard Meister, Marie Rock, Petra Obexer, Benjamin Hetzer, Evelyn Rabensteiner, Roman Crazzolara
Publikováno v:
Thrombosis Journal, Vol 22, Iss 1, Pp 1-8 (2024)
Abstract Background Thromboembolic complications are well known in the treatment of childhood acute lymphoblastic leukemia. Over the years it has not been possible to reach a consensus on a possible prophylaxis of thromboembolic events during intensi
Externí odkaz:
https://doaj.org/article/97aee1d3077a412ba722b64122000e9e
Autor:
Alexandra Podpeskar, Roman Crazzolara, Gabriele Kropshofer, Petra Obexer, Evelyn Rabensteiner, Miriam Michel, Christina Salvador
Publikováno v:
Frontiers in Pediatrics, Vol 10 (2022)
Survival of childhood acute lymphoblastic leukemia has significantly improved over the past decades. In the early years of chemotherapeutic development, improvement in survival rates could be attained only by increasing the cytostatic dose, also by m
Externí odkaz:
https://doaj.org/article/fecfc830c7044f589d434303559c8111
Autor:
Alexandra Podpeskar, Roman Crazzolara, Gabriele Kropshofer, Benjamin Hetzer, Evelyn Rabensteiner, Bernhard Meister, Petra Obexer, Christina Salvador
Publikováno v:
Nutrients, Vol 15, Iss 14, p 3239 (2023)
Background: As one of the few modifiable risk factors, the importance of dietary patterns for both disease prevention and treatment outcome in pediatric oncology has gained increasing popularity. Malnutrition is associated with lower survival rates,
Externí odkaz:
https://doaj.org/article/9b2a96c9596d439d93884dd8868a0813
Autor:
Judith Hagenbuchner, Veronika Obsilova, Teresa Kaserer, Nora Kaiser, Bettina Rass, Katarina Psenakova, Vojtech Docekal, Miroslava Alblova, Klara Kohoutova, Daniela Schuster, Tatsiana Aneichyk, Jan Vesely, Petra Obexer, Tomas Obsil, Michael J Ausserlechner
Publikováno v:
eLife, Vol 8 (2019)
FOXO transcription factors are critical regulators of cell homeostasis and steer cell death, differentiation and longevity in mammalian cells. By combined pharmacophore-modeling-based in silico and fluorescence polarization-based screening we identif
Externí odkaz:
https://doaj.org/article/2a1679493eee41128e3edfeaf260a091
Autor:
Maximilian A. Seiter, Stefan Salcher, Martina Rupp, Judith Hagenbuchner, Ursula Kiechl-Kohlendorfer, Jérémie Mortier, Gerhard Wolber, Judith M. Rollinger, Petra Obexer, Michael J. Ausserlechner
Publikováno v:
FEBS Open Bio, Vol 4, Iss C, Pp 659-671 (2014)
Defects in the regulation of apoptosis are one main cause of cancer development and may result from overexpression of anti-apoptotic proteins such as the X-linked inhibitor of apoptosis protein (XIAP). XIAP is frequently overexpressed in human leukem
Externí odkaz:
https://doaj.org/article/fcb857c5358b4ad3b38ba04b4dcf4e8a
Publikováno v:
Chemmedchem
New strategies to eradicate cancer stem cells in chronic myeloid leukemia (CML) include a combination of imatinib with peroxisome proliferator‐activated receptor gamma (PPARγ) ligands. Recently, we identified the partial PPARγ agonist telmisartan
FOXO transcription factors are critical regulators of cell homeostasis that control a plethora of different target genes and thereby steer cell death, differentiation, longevity and senescence in mammalian cells. The objective of the present study wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1ad60bd7ae8157a43abdbf6a71d35d9
https://doi.org/10.9734/bpi/nicb/v4/14349d
https://doi.org/10.9734/bpi/nicb/v4/14349d
Autor:
Daniela Schuster, Judith Hagenbuchner, Petra Huber-Cantonati, Thomas Gruber, Martin Tollinger, Thomas Müller, Heinz Zwierzina, Teresa Kaserer, Gilles A. Spoden, Michael J. Ausserlechner, Ronald Gust, Petra Obexer, Ursula Kiechl-Kohlendorfer, Sebastian Führer, Stefan Salcher
Publikováno v:
Oncogene
The transcription factor FOXO3 has been associated in different tumor entities with hallmarks of cancer, including metastasis, tumor angiogenesis, maintenance of tumor-initiating stem cells, and drug resistance. In neuroblastoma (NB), we recently dem
Autor:
Julia Lamprecht, Petra Obexer, Jessica Sagasser, Ronald Gust, Benjamin N. Ma, Stefanie Angerer, Brigitte Kircher, Stefan Salcher, Daniel Baecker, Martin Hermann
Publikováno v:
Journal of Medicinal Chemistry. 62:8053-8061
Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) complexes generate lipid-based ROS and induce ferroptosis in leukemia and neuroblastoma cell lines. The extent of ferroptosis on the mode of action is regulated by simple modifications of th
Publikováno v:
European journal of medicinal chemistry. 216
The development of resistance poses a serious problem in the therapy of cancer due to the necessity of a multiple-drug and unlimited treatment of affected patients. In chronic myeloid leukemia (CML), the introduction of imatinib has revolutionized th