Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Petra Nowotny"'
Autor:
Kerri S Rawson, David Dixon, Petra Nowotny, William M Ricci, Ellen F Binder, Thomas L Rodebaugh, Leah Wendleton, Peter Doré, Eric J Lenze
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120685 (2015)
Depressive symptoms are common in older adults after a disabling medical event and interfere with rehabilitation and recovery from the disability. This prospective study examined the role of genetic polymorphisms implicated in synaptic integrity and
Externí odkaz:
https://doaj.org/article/6d23462f9134437c80735be4ff0722ae
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50976 (2012)
Late onset Alzheimer's disease (LOAD) etiology is influenced by complex interactions between genetic and environmental risk factors. Large-scale genome wide association studies (GWAS) for LOAD have identified 10 novel risk genes: ABCA7, BIN1, CD2AP,
Externí odkaz:
https://doaj.org/article/33816ac0b59842e28994b8593c5b44a7
Autor:
Lesley Jones, Peter A. Holmans, Marian L. Hamshere, Denise Harold, Valentina Moskvina, Dobril Ivanov, Andrew Pocklington, Richard Abraham, Paul Hollingworth, Rebecca Sims, Amy Gerrish, Jaspreet Singh Pahwa, Nicola Jones, Alexandra Stretton, Angharad R. Morgan, Simon Lovestone, John Powell, Petroula Proitsi, Michelle K. Lupton, Carol Brayne, David C. Rubinsztein, Michael Gill, Brian Lawlor, Aoibhinn Lynch, Kevin Morgan, Kristelle S. Brown, Peter A. Passmore, David Craig, Bernadette McGuinness, Stephen Todd, Clive Holmes, David Mann, A. David Smith, Seth Love, Patrick G. Kehoe, Simon Mead, Nick Fox, Martin Rossor, John Collinge, Wolfgang Maier, Frank Jessen, Britta Schürmann, Hendrik van den Bussche, Isabella Heuser, Oliver Peters, Johannes Kornhuber, Jens Wiltfang, Martin Dichgans, Lutz Frölich, Harald Hampel, Michael Hüll, Dan Rujescu, Alison M. Goate, John S. K. Kauwe, Carlos Cruchaga, Petra Nowotny, John C. Morris, Kevin Mayo, Gill Livingston, Nicholas J. Bass, Hugh Gurling, Andrew McQuillin, Rhian Gwilliam, Panos Deloukas, Ammar Al-Chalabi, Christopher E. Shaw, Andrew B. Singleton, Rita Guerreiro, Thomas W. Mühleisen, Markus M. Nöthen, Susanne Moebus, Karl-Heinz Jöckel, Norman Klopp, H.-Erich Wichmann, Eckhard Rüther, Minerva M. Carrasquillo, V. Shane Pankratz, Steven G. Younkin, John Hardy, Michael C. O'Donovan, Michael J. Owen, Julie Williams
Publikováno v:
PLoS ONE, Vol 6, Iss 2 (2011)
Externí odkaz:
https://doaj.org/article/a0c75927ea024e6cbe0463ffa3cddcbf
Autor:
Lesley Jones, Peter A Holmans, Marian L Hamshere, Denise Harold, Valentina Moskvina, Dobril Ivanov, Andrew Pocklington, Richard Abraham, Paul Hollingworth, Rebecca Sims, Amy Gerrish, Jaspreet Singh Pahwa, Nicola Jones, Alexandra Stretton, Angharad R Morgan, Simon Lovestone, John Powell, Petroula Proitsi, Michelle K Lupton, Carol Brayne, David C Rubinsztein, Michael Gill, Brian Lawlor, Aoibhinn Lynch, Kevin Morgan, Kristelle S Brown, Peter A Passmore, David Craig, Bernadette McGuinness, Stephen Todd, Clive Holmes, David Mann, A David Smith, Seth Love, Patrick G Kehoe, Simon Mead, Nick Fox, Martin Rossor, John Collinge, Wolfgang Maier, Frank Jessen, Britta Schürmann, Reinhard Heun, Heike Kölsch, Hendrik van den Bussche, Isabella Heuser, Oliver Peters, Johannes Kornhuber, Jens Wiltfang, Martin Dichgans, Lutz Frölich, Harald Hampel, Michael Hüll, Dan Rujescu, Alison M Goate, John S K Kauwe, Carlos Cruchaga, Petra Nowotny, John C Morris, Kevin Mayo, Gill Livingston, Nicholas J Bass, Hugh Gurling, Andrew McQuillin, Rhian Gwilliam, Panos Deloukas, Ammar Al-Chalabi, Christopher E Shaw, Andrew B Singleton, Rita Guerreiro, Thomas W Mühleisen, Markus M Nöthen, Susanne Moebus, Karl-Heinz Jöckel, Norman Klopp, H-Erich Wichmann, Eckhard Rüther, Minerva M Carrasquillo, V Shane Pankratz, Steven G Younkin, John Hardy, Michael C O'Donovan, Michael J Owen, Julie Williams
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e13950 (2010)
BackgroundLate Onset Alzheimer's disease (LOAD) is the leading cause of dementia. Recent large genome-wide association studies (GWAS) identified the first strongly supported LOAD susceptibility genes since the discovery of the involvement of APOE in
Externí odkaz:
https://doaj.org/article/f60141a186cd4676b259fd600531e266
Autor:
Carlos Cruchaga, John S K Kauwe, Kevin Mayo, Noah Spiegel, Sarah Bertelsen, Petra Nowotny, Aarti R Shah, Richard Abraham, Paul Hollingworth, Denise Harold, Michael M Owen, Julie Williams, Simon Lovestone, Elaine R Peskind, Ge Li, James B Leverenz, Douglas Galasko, Alzheimer's Disease Neuroimaging Initiative, John C Morris, Anne M Fagan, David M Holtzman, Alison M Goate
Publikováno v:
PLoS Genetics, Vol 6, Iss 9, p e1001101 (2010)
Alzheimer's Disease (AD) is a complex and multifactorial disease. While large genome-wide association studies have had some success in identifying novel genetic risk factors for AD, case-control studies are less likely to uncover genetic factors that
Externí odkaz:
https://doaj.org/article/5639de89f57e446096241aa0086e24a8
Autor:
Heather R. Bailey, Shaney Flores, Petra Nowotny, Jesse Q. Sargent, Jeffrey M. Zacks, Alison Goate
Publikováno v:
Aging, Neuropsychology, and Cognition. 22:639-666
The apolipoprotein E (ApOE) ε4 allele is associated with neuropathological buildup of amyloid in the brain, and with lower performance on some laboratory measures of memory in some populations. In two studies, we tested whether ApOE genotype affects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3910196700f273b25632131ba232ce67
https://doi.org/10.1080/13825585.2015.1020916
https://doi.org/10.1080/13825585.2015.1020916
Autor:
Eric J. Lenze, Francis E. Lotrich, Bruce G. Pollock, Peter Dore, David Dixon, Petra Nowotny, Sean D. Kristjansson, Lauren D. Garfield
Publikováno v:
The American Journal of Geriatric Psychiatry. 22:971-979
Objective Antidepressant side effects are a significant public health issue, associated with poor adherence, premature treatment discontinuation, and, rarely, significant harm. Older adults assume the largest and most serious burden of medication sid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56afd23a567505cb348c7fa159df87d3
https://doi.org/10.1016/j.jagp.2013.07.003
https://doi.org/10.1016/j.jagp.2013.07.003
Autor:
Bruce G. Pollock, Peter Dore, Francis E. Lotrich, Anthony L. Hinrichs, Petra Nowotny, David Dixon, Eric J. Lenze, Meryl A. Butters
Publikováno v:
International Journal of Neuropsychopharmacology. 16:279-288
Older adults are among the most vulnerable to adverse cognitive effects of psychotropic medications and, therefore, the personalization of psychotropic treatment based on adverse drug reactions in this demographic is of great importance. We examined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::502106e980772982a1630ea120f8f27d
https://doi.org/10.1017/s1461145712000351
https://doi.org/10.1017/s1461145712000351
Autor:
Bruce L. Rollman, Petra Nowotny, Peichang Shi, Eric J. Lenze, Meryl A. Butters, Alison Goate, Rose C. Mantella, Carmen Andreescu, Paul M. Thompson
Publikováno v:
The American Journal of Geriatric Psychiatry. 19:482-490
Background Generalized anxiety disorder (GAD) is a common disorder in older adults, which has been linked to hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis in this age group. The authors examined whether treatment of GAD in older adul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9306414d1331be4b660081a68b4cc3a0
https://doi.org/10.1097/jgp.0b013e3181ec806c
https://doi.org/10.1097/jgp.0b013e3181ec806c
Autor:
Bradley T. Hyman, Tatiana Foroud, James J. Lah, Roger N. Rosenberg, Philip L. De Jager, John M. Ringman, Thomas D. Bird, Ramon Diaz-Arrastia, Wayne W. Poon, Barry Reisberg, Juan C. Troncoso, Peter St George-Hyslop, Deborah Blacker, Ronald C. Kim, Adam L. Boxer, Gerard D. Schellenberg, Douglas Galasko, John Hardy, Erik D. Roberson, Minerva M. Carrasquillo, Richard Mayeux, Steven L. Carroll, Elaine R. Peskind, Walter A. Kukull, Marla Gearing, Lee-Way Jin, Paul K. Crane, James D. Bowen, Deborah C. Mash, Carol A. Miller, Eileen H. Bigio, Duane Beekly, Kenneth B. Fallon, Bruce L. Miller, Eliezer Masliah, Charles DeCarli, Gyungah Jun, Mary Ganguli, M. Ilyas Kamboh, Steven E. Arnold, Patricia L. Kramer, Gregory A. Jicha, David G. Clark, Lon S. Schneider, William G. Ellis, Anna Karydas, Alison Goate, Michael A. Slifer, Matthew P. Frosch, Steven G. Younkin, Steven T. DeKosky, F. Yesim Demirci, John Q. Trojanowski, Jeffrey Kaye, Sandra Weintraub, Jonathan D. Glass, Lindy E. Harrell, Adam C. Naj, Frank Martiniuk, Harry V. Vinters, Gail P. Jarvik, Ronald L. Hamilton, Ruchita Rajbhandary, Wayne C. McCormick, Neill R. Graff-Radford, Allan I. Levey, Jennifer Williamson, Daniel C. Marson, Andrew McDavid, John R. Gilbert, Thomas H. Beach, Christine M. Hulette, David A. Bennett, William P. Seeley, Christopher S. Carlson, Amanda J. Myers, Hakon Hakonarson, Debby W. Tsuang, Kathryn L. Lunetta, James R. Burke, Sid Gilman, John C. Morris, Bradley F. Boeve, Oscar L. Lopez, Nilufer Ertekin-Taner, Thomas J. Montine, Daniel P. Perl, Eric M. Reiman, Joseph F. Quinn, Susan M. McCurry, Paul Gallins, Murray A. Raskind, Badri N. Vardarajan, Joshua A. Sonnen, Robert S. Stern, Denis A. Evans, Lawrence S. Honig, Ekaterina Rogaeva, John H. Growdon, Michael L. Shelanski, Vivianna M. Van Deerlin, Joseph E. Parisi, Mary Sano, Dennis W. Dickson, Steven H. Ferris, Randall L. Woltjer, Li-San Wang, Jonathan L. Haines, Bruno Giordani, Martin R. Farlow, Jason J. Corneveaux, Gary W. Beecham, Clinton T. Baldwin, Ann C. McKee, Jean Paul Vonsattel, Julie A. Schneider, Malcolm B. Dick, Kelley Faber, John S. K. Kauwe, Neil W. Kowall, Wendy J. Mack, W Marsel Mesulam, Nigel J. Cairns, Nancy Johnson, Jacqueline L. Buros, Eric B. Larson, Ronald C. Petersen, Laura B. Cantwell, Margaret A. Pericak-Vance, Elizabeth Head, Petra Nowotny, Joseph D. Buxbaum, Andrew J. Saykin, Robert C. Green, Lindsay A. Farrer, Carlos Cruchaga, Joshua W. Miller, Matthew J. Huentelman, Rudolph E. Tanzi, Beth A. Dombroski, Andrew P. Lieberman, Daniel H. Geschwind, Robert W Barber, Jeffrey L. Cummings, Charles D. Smith, Bernardino Ghetti, Salvatore Spina, Regina M. Carney, Kathleen A. Welsh-Bohmer, Jason Karlawish, Edward H. Koo, Eden R. Martin, M. Michael Barmada, Carl W. Cotman, Helena C. Chui
Publikováno v:
Nature genetics
The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage 1) and two replication stages (stages 2 and 3). Both joint an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f5643882a13dc63b3c672e16c446352
http://europepmc.org/articles/PMC3090745
http://europepmc.org/articles/PMC3090745