Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Petra Martinsson"'
Publikováno v:
British Journal of Pharmacology. 137:568-573
The present study was aimed at elucidating the apoptosis inhibitory properties of the cyanoguanidine CHS 828. CHS 828 exhibits impressive cytotoxic activity in vitro and in vivo. Apoptosis is not its main mode of cytotoxic effect, and we have previou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de04e2bd38bbf3d7c5ebf4be6ba01ae6
https://doi.org/10.1038/sj.bjp.0704888
https://doi.org/10.1038/sj.bjp.0704888
Publikováno v:
Biochemical Pharmacology. 63:1491-1498
The role of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) and the ADP-ribosylation inhibitor 3-aminobenzamide (3-ABA) in the cytotoxicity induced by the novel antitumoral cyanoguanidine CHS 828 was investigated in the human lymphoma cell line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4ff5f7c3c14d89b0f5e2b284ff2ebca
https://doi.org/10.1016/s0006-2952(02)00890-0
https://doi.org/10.1016/s0006-2952(02)00890-0
Publikováno v:
Anti-Cancer Drugs. 12:699-705
Cell death induced by etoposide in the human lymphoma cell line U-937 GTB was characterized. Activity of caspases -3, -8 and -9 was measured by spectrophotometric detection of specific cleavage products, DNA fragmentation by TdT-mediated dUTP nick en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c77cd37ad9acf181b73fd56266c1f651
https://doi.org/10.1097/00001813-200109000-00009
https://doi.org/10.1097/00001813-200109000-00009
Publikováno v:
European Journal of Pharmacology. 417:181-187
N-(6-(4-chlorophenoxy)hexyl)-N'-cyano-N"-4-pyridylguanidine (CHS 828), with promising antitumoral effects in vitro and in vivo, is currently in clinical Phase I and II studies. Its exact mechanism of action is unclear, but previous studies indicate t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c1b7dd4f89a47337e67741377d3e969
https://doi.org/10.1016/s0014-2999(01)00925-6
https://doi.org/10.1016/s0014-2999(01)00925-6
Autor:
Gunnar Liminga, M. de la Torre, Petra Martinsson, Sumeer Dhar, A. Lukinius, S. Bashir Hassan, Jörgen Kristensen, E. Jonsson, Lise Binderup, R. Larsson
Publikováno v:
European journal of cancer (Oxford, England : 1990). 37(2)
CHS 828, a novel pyridyl cyanoguanidine, has shown potent antitumour activity both in vitro and in vivo and is currently undergoing phase I evaluation in humans in collaboration with the European Organization for Research and Treatment of Cancer (EOR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9e1a393a7ba64bb93408d2ec9902245
https://pubmed.ncbi.nlm.nih.gov/11166155
https://pubmed.ncbi.nlm.nih.gov/11166155
Publikováno v:
Biochemical pharmacology. 60(12)
Effects of calcein acetoxymethyl ester (calcein/AM) on macromolecular synthesis, mitochondrial membrane potential, and mode of death were studied in U-937 GTB lymphoma cells. This was accomplished by measurements of 14 C-labeled thymidine and leucine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757b05ffa237a6b55f387c2a88abfd70
https://pubmed.ncbi.nlm.nih.gov/11108790
https://pubmed.ncbi.nlm.nih.gov/11108790
Publikováno v:
European journal of clinical pharmacology. 52(3)
The fluorometric microculture cytotoxic assay was employed for characterisation of the cytotoxic effect of cyclosporin A (CsA) and its non-immunosuppressive analogue SDZ PSC 833, [3-keto-Bmt1]-[Val2]-cyclosporin (PSC) in tumour cells from patients wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89b8a1e0e9492939d725e6665796217c
https://pubmed.ncbi.nlm.nih.gov/9218926
https://pubmed.ncbi.nlm.nih.gov/9218926