Immune activation correlates with and predicts CXCR4 co-receptor tropism switch in HIV-1 infection

Autor: Ingrid Schellens, Hugo A. Tempelman, Maria A. Papathanasopoulos, José A. M. Borghans, Annemarie M. J. Wensing, Neeltje A. Kootstra, M. Nijhuis, Dorien de Jong, Tholakele Mathe, Petra M. van Ham, Sigrid Otto, Pauline J. Schipper, Zita Kruize, Robert Moraba, Bridgette Janine Connell, Francois Venter, Kiki Tesselaar, Lucas E Hermans

Publikováno v: Scientific reports, 10(1):15866. Nature Publishing Group
Scientific Reports
Connell, B J, Hermans, L E, Wensing, A M J, Schellens, I, Schipper, P J, van Ham, P M, de Jong, D T C M, Otto, S, Mathe, T, Moraba, R, Borghans, J A M, Papathanasopoulos, M A, Kruize, Z, Venter, F W D, Kootstra, N A, Tempelman, H, Tesselaar, K & Nijhuis, M 2020, ' Immune activation correlates with and predicts CXCR4 co-receptor tropism switch in HIV-1 infection ', Scientific Reports, vol. 10, no. 1, 15866 . https://doi.org/10.1038/s41598-020-71699-z
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports, 10(1):15866. Nature Publishing Group

HIV-1 cell entry is mediated by binding to the CD4-receptor and chemokine co-receptors CCR5 (R5) or CXCR4 (X4). R5-tropic viruses are predominantly detected during early infection. A switch to X4-tropism often occurs during the course of infection. X

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde2477eedf2d7c138c7ad8aa22467c4
https://pure.amc.nl/en/publications/immune-activation-correlates-with-and-predicts-cxcr4-coreceptor-tropism-switch-in-hiv1-infection(b10e0da7-a0ea-4b0d-853e-5221f69a365b).html

Development of sensitive ddPCR assays to reliably quantify the proviral DNA reservoir in all common circulating HIV subtypes and recombinant forms

Autor: Wilco J. van Snippenberg, Annemarie M. J. Wensing, Monique Nijhuis, Andy I. M. Hoepelman, Petra M. van Ham, K. Bosman, Dorien M. C. de Jong, Aster E. Pijning

Publikováno v: Journal of the International AIDS Society [E], 21(9). International AIDS Society
Journal of the International AIDS Society

Introduction The latent reservoir is the main barrier on the road to HIV cure, and clinical approaches towards eradication are often evaluated by their effect on proviral DNA. To ensure inclusiveness and representativeness in HIV cure studies, provir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f5d3158a5699c3cc101f3db93cbe54
https://pubmed.ncbi.nlm.nih.gov/30375818

Maraviroc is able to inhibit dual-R5 viruses in a dual/mixed HIV-1-infected patient

Autor: Monique Nijhuis, Petra M. van Ham, Steven F. L. van Lelyveld, Dorien de Jong, Jori Symons, Andy I. M. Hoepelman, Annemarie M. J. Wensing

Publikováno v: Journal of Antimicrobial Chemotherapy. 66:890-895

Objectives: Maraviroc is the first licensed chemokine co-receptor 5 (CCR5) co-receptor antagonist in clinical practice. It is currently being used in patients harbouring exclusively CCR5-tropic virus. The objective of the study was to investigate the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa9d338945d53803cd664e0e2c25e223
https://doi.org/10.1093/jac/dkq535

Dependence on the CCR5 coreceptor for viral replication explains the lack of rebound of CXCR4-predicted HIV variants in the Berlin patient

Autor: Petra M. van Ham, Gero Hütter, Jori Symons, Linos Vandekerckhove, Monique Nijhuis, Annemarie M. J. Wensing, Steven G. Deeks

Publikováno v: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 59(4)

The "Berlin patient" is the first patient cured of HIV-1 infection after allogeneic transplantation with nonfunctional CCR5 coreceptor stem cells. We demonstrate that CXCR4-predicted minority viruses present prior to transplantation were unable to re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a41f8b95e96495de22e6e9870ae5ca
https://pubmed.ncbi.nlm.nih.gov/24759824

Evolution and viral characteristics of a long-term circulating resistant HIV-1 strain in a cluster of treatment-naive patients

Autor: Petra M. van Ham, Annemarie M. J. Wensing, L. Marije Hofstra, Monique Nijhuis, Marieke Pingen, Wouter F W Bierman, Alberdina M. Simoons-Smit, Annelies Riezebos-Brilman, Tania Mudrikova

Publikováno v: Hofstra, L M, Nijhuis, M, Pingen, M, Mudrikova, T, Riezebos-Brilman, A, Smit, A M, Van Ham, P M, Bierman, W F W & Wensing, A M J 2013, ' Evolution and viral characteristics of a long-term circulating resistant HIV-1 strain in a cluster of treatment-naive patients ', Journal of Antimicrobial Chemotherapy, vol. 68, no. 6, pp. 1246-1250 . https://doi.org/10.1093/jac/dkt038
Journal of Antimicrobial Chemotherapy, 68(6), 1246-1250. Oxford University Press

Transmitted resistant HIV may revert to wild-type in the absence of drug pressure due to reduced replication capacity (RC). We observed eight therapy-naive patients infected with HIV harbouring four mutations at nucleoside reverse transcriptase inhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9da03a42bb7e8da02a2bf8d21b92b987
https://pubmed.ncbi.nlm.nih.gov/23467175