Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Petra M. Kopp"'
Autor:
Benjamin T. Goult, Dorit Hanein, Petra M. Kopp, Igor L. Barsukov, Xiao-Ping Xu, Neil Bate, Alexandre R. Gingras, Bipin Patel, Niels Volkmann, Mark F. Swift, David R. Critchley
Publikováno v:
Journal of Structural Biology. 184:21-32
Talin is a large adaptor protein that activates integrins and couples them to cytoskeletal actin. Talin contains an N-terminal FERM (band 4.1, ezrin, radixin, moesin) domain (the head) linked to a flexible rod comprised of 13 amphipathic helical bund
Publikováno v:
Biochemical Society transactions. 39(2)
Tetraspanin CD9 is associated with integrin adhesion receptors and it was reported that CD9 regulates integrin-dependent cell migration and invasion. Pro- and anti-migratory effects of CD9 have been linked to adhesion-dependent signalling pathways, i
Autor:
Petra M. Kopp, Paul R. Elliott, Benjamin T. Goult, Neil Bate, Gordon C. K. Roberts, J. Günter Grossmann, Igor L. Barsukov, David R. Critchley
Publikováno v:
Structure(London, England:1993)
Summary FERM domains are found in a diverse superfamily of signaling and adaptor proteins at membrane interfaces. They typically consist of three separately folded domains (F1, F2, F3) in a compact cloverleaf structure. The crystal structure of the N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1324c51cc8f16f7f9e4767688e2a6e8d
https://kar.kent.ac.uk/42120/1/2010_Elliott_Structure.pdf
https://kar.kent.ac.uk/42120/1/2010_Elliott_Structure.pdf
Autor:
Igor L. Barsukov, Benjamin T. Goult, Neil Bate, Alexandre R. Gingras, Gordon C. K. Roberts, David R. Critchley, Bipin Patel, Petra M. Kopp, Jonas Emsley
Publikováno v:
The Journal of Biological Chemistry
Talin is an adaptor protein that couples integrins to F-actin. Structural studies show that the N-terminal talin head contains an atypical FERM domain, whereas the N- and C-terminal parts of the talin rod include a series of α-helical bundles. Howev
Autor:
David R. Critchley, Nicholas P.J. Brindle, Emmanuel Debrand, Petra M. Kopp, Susan J. Monkley, Catrin Pritchard, Benjamin T. Goult, Daniela Mazzeo, Tania M. Hansen, Neil Bate, Uta Praekelt, Stacey Coleman, Alexandre R. Gingras
Publikováno v:
European Journal of Cell Biology
Talin binds to and activates integrins and is thought to couple them to cytoskeletal actin. However, functional studies on talin have been restricted by the fact that most cells express two talin isoforms. Here we show that human umbilical vein endot
Autor:
Franceso Conti, Ming-Zhi Zhang, Robert S. Ross, Ana Maria Manso, Petra M. Kopp, Uta Praekelt, Raymond C. Harris, Bipin Patel, Neil Bate, Kerstin Rehm, David R. Critchley, Stefan Linder, Susan J. Monkley, Emmanuel Debrand, Roy Zent
Publikováno v:
European Journal of Cell Biology
Talins are adaptor proteins that connect the integrin family of cell adhesion receptors to cytoskeletal actin. Vertebrates express two closely related talins encoded by separate genes, and while it is well established that talin1 plays a key role in