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Patulin influences the expression of Th1/Th2 cytokines by activated peripheral blood mononuclear cells and T cells through depletion of intracellular glutathione

Autor: Albert Duschl, Gertie Janneke Oostingh, Petra Luft, Yvonne Gruijthuijsen, Jutta Horejs-Hoeck, Irina Lehmann

Publikováno v: Environmental Toxicology. 23:84-95

Patulin is a mold toxin secreted mainly by fungi of the Penicillium species. Exposure generally results from consumption of moldy fruits and fruit products. Since recent studies identified mold exposure as a risk factor for allergic diseases, we exam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3658fe302c39bebe4024360e40464712
https://doi.org/10.1002/tox.20309

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IL-4 and IL-13 Induce SOCS-1 Gene Expression in A549 Cells by Three Functional STAT6-Binding Motifs Located Upstream of the Transcription Initiation Site

Autor: Gerhard Regl, Jutta Horejs-Hoeck, Angela Schmiedlechner, Petra Luft, Anna-Maria Frischauf, Albert Duschl, Fritz Aberger, Daniel Hebenstreit

Publikováno v: ResearcherID

Proteins of the suppressors of cytokine signaling (SOCS) family have important functions as negative regulators of cytokine signaling. We show here that SOCS-1 expression can be induced in the human epithelial lung cell line A549 by IL-4 and IL-13. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71aa2e943a08aaaddbb35d493d0c714c
https://doi.org/10.4049/jimmunol.171.11.5901

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The diesel exhaust component pyrene induces expression of IL-8 but not of eotaxin

Autor: Ulrich Pöschl, Markus Haake, C. Schauer, Heike Bömmel, Michael Kracht, Joachim Bartels, Petra Luft, Jutta Horejs-Hoeck, Herbert Hein, Albert Duschl

Publikováno v: International Immunopharmacology. 3:1371-1379

Environmental pollutants can influence the expression of immunoregulatory molecules and, in this way, promote allergies. The local synthesis of proinflammatory chemokines is an important aspect in the development of allergic airway inflammation. We h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08224d2ebb89014f0913600c71240409
https://doi.org/10.1016/s1567-5769(03)00135-8

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Antibody microarray-based profiling of complex specimens: systematic evaluation of labeling strategies

Autor: Albert Duschl, Petra Luft, Yana V. Syagailo, Sven Rüffer, Virryan Banzon, Jörg D. Hoheisel, Wlad Kusnezow, René Schaal, Christoph Schröder

Publikováno v: Proteomics. 7(11)

Antibody microarrays have often had limited success in detection of low abundant proteins in complex specimens. Signal amplification systems improve this situation, but still are quite laborious and expensive. However, the issue of sensitivity is mor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee4be329a9dee153a1ee5fc14925789
https://pubmed.ncbi.nlm.nih.gov/17474144

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SOCS-1 and SOCS-3 inhibit IL-4 and IL-13 induced activation of Eotaxin-3/CCL26 gene expression in HEK293 cells

Autor: Angela Schmiedlechner, Albert Duschl, Daniel Hebenstreit, Jutta Horejs-Hoeck, Petra Luft

Publikováno v: Molecular immunology. 42(3)

Secretion of various chemokines including Eotaxin-3/CCL26 results in the attraction of eosinophils to sites of allergic inflammation. IL-4/IL-13-induced activation of the Eotaxin-3/CCL26 gene in human dermal fibroblasts was shown to be a STAT6-depend

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::365651d8a6d59918d25768ac0be2c060
https://pubmed.ncbi.nlm.nih.gov/15589317

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