Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Petra Leyendecker"'
1
Opioid-induced bowel dysfunction in cancer-related pain: Causes, consequences, and a novel approach for its management
Autor: Peter Holzer, PhD, Sam H. Ahmedzai, BSc, MBChB, FRCP, Norbert Niederle, MD, Petra Leyendecker, PhD, Michael Hopp, MD, Björn Bosse, Statistics (Diploma), Ingrid Spohr, PhD, Karen Reimer, MD
Publikováno v: Journal of Opioid Management. 5:145-151
Opioids are the mainstay of management for patients with cancer-related pain. Although the analgesic efficacy of opioid therapy is well documented, the recent European Pain in Cancer survey demonstrated that the management of moderate-to-severe pain
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::629dbbe5b67da3cfa9232e432950c3d0
https://doi.org/10.5055/jom.2009.0015
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2
Long-term efficacy and safety of combined prolonged-release oxycodone and naloxone in the management of non-cancer chronic pain
Autor: L Tarau, Winfried Meissner, Karen Reimer, H Dürr, R. Uhl, J Lejcko, Michael Hopp, Marek Hakl, Pavel Ševčík, R Hrib, Petra Leyendecker, Andreas Sandner-Kiesling
Publikováno v: International Journal of Clinical Practice
The aim of this study was to assess safety and efficacy of fixed combination oxycodone prolonged release (PR)/naloxone PR in terms of both analgesia and improving opioid-induced bowel dysfunction (OIBD) and associated symptoms, such as opioid-induced
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc4c0e232cf77fbcd4b189573284d1e
https://doi.org/10.1111/j.1742-1241.2010.02360.x
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3
Combined prolonged-release oxycodone and naloxone improves bowel function in patients receiving opioids for moderate-to-severe non-malignant chronic pain: a randomised controlled trial
Autor: T. Nichols, Petra Leyendecker, W. Kremers, U Schutter, B. Krain, P D Rogers, S Bond, R. Uhl, Karen Reimer, O. Löwenstein, M. Hopp
Publikováno v: Expert Opinion on Pharmacotherapy. 10:531-543
This randomised, double-blind, double-dummy, parallel-group multicentre study assessed the impact of a total daily dose of 60-80 mg oral oxycodone prolonged-release (PR)/naloxone PR (OXN PR) as fixed-ratio combination for patients with opioid-induced
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa42937ed9268758528eaa6af5ec0e81
https://doi.org/10.1517/14656560902796798
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4
A randomised controlled trial with prolonged-release oral oxycodone and naloxone to prevent and reverse opioid-induced constipation
Autor: Christian Ruckes, Joachim Nadstawek, Michael Hopp, Karen Reimer, Wolfgang Fleischer, Petra Leyendecker, Winfried Meissner, Stefan Mueller-Lissner, Stefan Wirz
Publikováno v: European Journal of Pain. 13:56-64
Background Opioid-induced constipation can have a major negative impact on patients’ quality of life. This randomised, double-blinded study evaluated the analgesic efficacy of prolonged-release (PR) oral oxycodone when co-administered with PR oral
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42a52463c68690fc1af6a5f34ffd460e
https://doi.org/10.1016/j.ejpain.2008.06.012
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5
Analgesic Efficacy and Safety of Oxycodone in Combination With Naloxone as Prolonged Release Tablets in Patients With Moderate to Severe Chronic Pain
Autor: Karen Reimer, Petra Leyendecker, Dana Vondrackova, Winfried Meissner, Istvan Szombati, Susanne Weber, Kai Hermanns, Michael Hopp, Birgit Grothe, Christian Ruckes, Wolfgang Fleischer
Publikováno v: The Journal of Pain. 9:1144-1154
This randomized, double-blind, placebo- and active-controlled, parallel-group study was designed to demonstrate the superiority of oxycodone in combination with naloxone in a prolonged release (PR) formulation over placebo with respect to analgesic e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfec22045aa2c93238b4c1c0bb621c70
https://doi.org/10.1016/j.jpain.2008.06.014
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6
Fixed-ratio combination oxycodone/naloxone compared with oxycodone alone for the relief of opioid-induced constipation in moderate-to-severe noncancer pain
Autor: K. Simpson, W. Kremers, S. Müller-Lissner, T. Nichols, B. Krain, Karen Reimer, J. Troy Ferrarons, O. Löwenstein, Petra Leyendecker, M. Hopp, B. Bosse, J. De Andrés
Publikováno v: Current Medical Research and Opinion. 24:3503-3512
Opioid therapy is frequently associated with treatment-limiting constipation. Naloxone is an opioid antagonist with low oral systemic bioavailability. This Phase III clinical trial assessed the safety and efficacy of an oral fixed-ratio combination o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3de994629e4656888312d4a76a5947db
https://doi.org/10.1185/03007990802584454
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7
Patient assessment of a novel therapeutic approach for the treatment of severe, chronic pain
Autor: Wolfgang Fleischer, Michael Hopp, Christian Ruckes, Joachim Nadstawek, Stefan Wirz, Petra Leyendecker, Karen Reimer
Publikováno v: International Journal of Clinical Practice. 62:1159-1167
SUMMARY Background and objectives: Opioid-induced constipation can have a major negative impact on patients’ quality of life. This randomised clinical trial evaluated patient assessment of the efficacy and tolerability of oral prolonged-release (PR
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55c0d1ec1df3b59002ab0ca5eed62748
https://doi.org/10.1111/j.1742-1241.2008.01820.x
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8
A randomized, double-blind, active-controlled, double-dummy, parallel-group study to determine the safety and efficacy of oxycodone/naloxone prolonged-release tablets in patients with moderate/severe, chronic cancer pain
Autor: Michael Hopp, Friedemann Nauck, B. Bosse, Gil Bar-Sela, Petra Leyendecker, Sam H Ahmedzai
Publikováno v: Palliative Medicine
Objective: An examination of whether oxycodone/naloxone prolonged-release tablets (OXN PR) can improve constipation and maintain analgesia, compared with oxycodone prolonged-release tablets (OxyPR) in patients with moderate/severe cancer pain. Method
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e213f2860a60952909be0ee9f698dd0f
http://resolver.sub.uni-goettingen.de/purl?gs-1/8355
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