Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks.

Autor: Petra Langerak, Eva Mejia-Ramirez, Oliver Limbo, Paul Russell

Publikováno v: PLoS Genetics, Vol 7, Iss 9, p e1002271 (2011)

The multifunctional Mre11-Rad50-Nbs1 (MRN) protein complex recruits ATM/Tel1 checkpoint kinase and CtIP/Ctp1 homologous recombination (HR) repair factor to double-strand breaks (DSBs). HR repair commences with the 5'-to-3' resection of DNA ends, gene

Externí odkaz: https://doaj.org/article/fc71716de1324abba27736f0887b6d72

The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain

Autor: Bruno Martoglio, Michael Young, Sherry Niessen, Petra Langerak, Michael P. Cooke, Daniel R. Beisner, Carol Dahlberg, S. Sutton, Benjamin F. Cravatt, Albert E. Parker, Ursula Bodendorf, Tim Wiltshire, Whitney Barnes, Francella Otero, Laurent Poirot

Publikováno v: The Journal of Experimental Medicine

The protease Sppl2a cleaves the N-terminal fragment of invariant chain (CD74) and is required for efficient B cell development and function.
B cell development requires tight regulation to allow for the generation of a diverse repertoire while p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db8cd2a3df60b5f6449a15af6a4194a
http://europepmc.org/articles/PMC3549714

Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub during somatic hypermutation

Autor: Petra Langerak, Paul C.M. van den Berk, Peter H.L. Krijger, Heinz Jacobs

Publikováno v: The Journal of Experimental Medicine

During somatic hypermutation (SHM), B cells introduce mutations into their immunoglobulin genes to generate high affinity antibodies. Current models suggest a separation in the generation of G/C transversions by the Ung2-dependent pathway and the gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::593bb63531b85e9feb5190e7d8e134b9
https://doi.org/10.1084/jem.20091707

Critical Function of γH2A in S-Phase

Autor: Petra Langerak, Paul Russell, Oliver Limbo, Eva Mejia-Ramirez

Publikováno v: PLoS Genetics, Vol 11, Iss 9, p e1005517 (2015)
PLoS Genetics

Phosphorylation of histone H2AX by ATM and ATR establishes a chromatin recruitment platform for DNA damage response proteins. Phospho-H2AX (γH2AX) has been most intensively studied in the context of DNA double-strand breaks caused by exogenous clast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aacd5d469d262215ba2446f927a12f2f
http://europepmc.org/articles/PMC4569340?pdf=render

Epidermal growth factor receptor-induced activato protein 1 activity controls density-dependent growht inhibition in normal rat kidney fibroblasts

Autor: P.H.J. Peters, Jan Lankelma, Petra Langerak, Hans V. Westerhoff, Jorrit J. Hornberg, Everardus J.J. van Zoelen, Henk L. Dekker

Publikováno v: Molecular Biotechnology, 34, 101-108
Hornberg, J J, Dekker, H, Peters, P H J, Langerak, P, Westerhoff, H V, Lankelma, J & Zoelen, E J J 2006, ' Epidermal growth factor receptor-induced activato protein 1 activity controls density-dependent growht inhibition in normal rat kidney fibroblasts. ', Molecular Biotechnology, vol. 34, pp. 101-108 . https://doi.org/10.1385/MB:34:2:101
Molecular Biotechnology, 34, 101-108. Humana Press
Molecular Biotechnology, 34, 2, pp. 101-108

Density-dependent growth inhibition secures tissue homeostasis. Dysfunction of the mechanisms, which regulate this type of growth control is a major cause of neoplasia. In confluent normal rat kidney (NRK) fibroblasts, epidermal growth factor (EGF) r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5f9f2c1af191154260ac01a7584c1ce
https://research.vu.nl/en/publications/2069e45c-e7ec-4b5e-bf95-fc0a55dd3d93