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pro vyhledávání: '"Petra L Kohler"'
Autor:
Petra L Kohler, Seth D Greenwood, Suba Nookala, Malak Kotb, David M Kranz, Patrick M Schlievert
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41157 (2012)
Staphylococcus aureus produces superantigens (SAgs) that bind and cross-link T cells and APCs, leading to activation and proliferation of immune cells. SAgs bind to variable regions of the β-chains of T cell receptors (Vβ-TCRs), and each SAg binds
Externí odkaz:
https://doaj.org/article/fbc2fe7868724b3aa93e39acbd7679a5
Akademický článek
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Autor:
Candace N. Rouchon, Arielle J. Weinstein, Carissa A. Hutchison, Zahra B. Zubair-Nizami, Petra L. Kohler, Kristi L. Frank
Publikováno v:
Journal of Bacteriology. 204
Enterococcus faecalis is a leading cause of health-care-associated infections for which there are limited treatment options. E. faecalis is resistant to several antibiotics and to high concentrations of the human antimicrobial enzyme lysozyme. The mo
Publikováno v:
Wound Repair and Regeneration
Microbial biofilms have become increasingly recognized as a cause of wound chronicity. There are several topical antimicrobial wound care products available for use; however, their effectiveness has routinely been demonstrated with planktonic microor
Autor:
Wilmara Salgado-Pabón, Joseph A. Merriman, Elizabeth A. Mueller, Adam R. Spaulding, John R. Kirby, Petra L. Kohler, Patrick M. Schlievert, Olivia N. Chuang-Smith, Bao G. Vu
Publikováno v:
Antimicrobial Agents and Chemotherapy. 57:5432-5437
Gram-positive bacteria cause serious human illnesses through combinations of cell surface and secreted virulence factors. We initiated studies with four of these organisms to develop novel topical antibacterial agents that interfere with growth and e
Autor:
Karen A. Cloud-Hansen, Kathleen T. Hackett, Petra L. Kohler, Joseph P. Dillard, Holly Hamilton, Yolande A. Chan, Nicholas A Turner
Publikováno v:
Journal of Bacteriology. 195:1666-1679
Neisseria gonorrhoeae uses a type IV secretion system (T4SS) to secrete chromosomal DNA into the surrounding milieu. The DNA is effective in transforming gonococci in the population, and this mechanism of DNA donation may contribute to the high degre
Autor:
Elizabeth A. Stohl, H. Steven Seifert, Kathleen T. Hackett, Yolande A. Chan, Petra L. Kohler, Joseph P. Dillard
Publikováno v:
Journal of Biological Chemistry. 287:11222-11233
Symptomatic gonococcal infection, caused exclusively by the human-specific pathogen Neisseria gonorrhoeae (the gonococcus), is characterized by the influx of polymorphonuclear leukocytes (PMNs) to the site of infection. Although PMNs possess a potent
Autor:
Marnie L. Peterson, Ying Chi Lin, Petra L. Kohler, Alexander R. Horswill, Kristi L. Strandberg, Patrick M. Schlievert, Michael E. Olson, Michele J. Anderson
Publikováno v:
Biochemistry. 50:7157-7167
Pulsed-field gel electrophoresis (PFGE) clonal type USA200 is the most widely disseminated Staphylococcus aureus colonizer of the nose and is a major cause of toxic shock syndrome (TSS). Exoproteins derived from these organisms have been suggested to
Publikováno v:
Molecular Microbiology. 71:158-171
Neisseria gonorrhoeae (Gc), an obligate human bacterial pathogen, utilizes pilin antigenic variation to evade host immune defenses. Antigenic variation is driven by recombination between expressed (pilE) and silent (pilS) copies of the pilin gene, wh
Publikováno v:
Journal of Bacteriology. 189:5421-5428
Type IV secretion systems require peptidoglycan lytic transglycosylases for efficient secretion, but the function of these enzymes is not clear. The type IV secretion system gene cluster of Neisseria gonorrhoeae encodes two peptidoglycan transglycosy