Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Petra L Bakker"'
Autor:
Irena Bočkaj, Tosca E I Martini, Eduardo S de Camargo Magalhães, Petra L Bakker, Tiny G J Meeuwsen-de Boer, Inna Armandari, Saskia L Meuleman, Marin T Mondria, Colin Stok, Yannick P Kok, Bjorn Bakker, René Wardenaar, Jonas Seiler, Mathilde J C Broekhuis, Hilda van den Bos, Diana C J Spierings, Femke C A Ringnalda, Hans Clevers, Ulrich Schüller, Marcel A T M van Vugt, Floris Foijer, Sophia W M Bruggeman
Publikováno v:
PLoS Genetics, Vol 17, Iss 11, p e1009868 (2021)
While comprehensive molecular profiling of histone H3.3 mutant pediatric high-grade glioma has revealed extensive dysregulation of the chromatin landscape, the exact mechanisms driving tumor formation remain poorly understood. Since H3.3 mutant gliom
Externí odkaz:
https://doaj.org/article/e3b40f56962c48b392b15bc0a11a6d55
Autor:
Lin Zhou, Siqi Zheng, Fernando R Rosas Bringas, Bjorn Bakker, Judith E Simon, Petra L Bakker, Hinke G Kazemier, Michael Schubert, Maurits Roorda, Marcel A T M van Vugt, Michael Chang, Floris Foijer
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 12 (2021)
AbstractMaternal embryonic leucine zipper kinase (MELK) is frequently overexpressed in cancer, but the role of MELK in cancer is still poorly understood. MELK was shown to have roles in many cancer-associated processes including tumor growth, chemoth
Externí odkaz:
https://doaj.org/article/47ad807053204d65be2ed713aa553e49
Autor:
Irena Bočkaj, Tosca E. I. Martini, Marlinde J. Smit, Inna Armandari, Bjorn Bakker, René Wardenaar, Tiny G. J. Meeuwsen-de Boer, Petra L. Bakker, Diana C. J. Spierings, Eelco W. Hoving, Victor Guryev, Floris Foijer, Sophia W. M. Bruggeman
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9852 (2022)
Medulloblastoma is a pediatric brain malignancy that consists of four transcriptional subgroups. Structural and numerical aneuploidy are common in all subgroups, although they are particularly profound in Group 3 and Group 4 medulloblastoma and in a
Externí odkaz:
https://doaj.org/article/f73240404c5b403f963b1f47798fd400
Autor:
Christy Hong, Michael Schubert, Andréa E. Tijhuis, Marta Requesens, Maurits Roorda, Anouk van den Brink, Lorena Andrade Ruiz, Petra L. Bakker, Tineke van der Sluis, Wietske Pieters, Mengting Chen, René Wardenaar, Bert van der Vegt, Diana C. J. Spierings, Marco de Bruyn, Marcel A. T. M. van Vugt, Floris Foijer
Publikováno v:
Nature, 607, 366-373. Nature Publishing Group
Chromosomal instability (CIN) drives cancer cell evolution, metastasis and therapy resistance, and is associated with poor prognosis1. CIN leads to micronuclei that release DNA into the cytoplasm after rupture, which triggers activation of inflammato
Autor:
Amanda Faria Assoni, Erika N. Guerrero, René Wardenaar, Danyllo Oliveira, Petra L. Bakker, Valdemir Melechco Carvalho, Oswaldo Keith Okamoto, Mayana Zatz, Floris Foijer
Amyotrophic lateral sclerosis type 6 (ALS6) is a familial subtype of ALS linked to Fused in Sarcoma (FUS) gene mutation. FUS mutations lead to decreased global protein synthesis, but the mechanism that drives this has not been established. Here, we u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32525793cf1bc102d3ebd6655478acdf
https://doi.org/10.1101/2022.12.05.519150
https://doi.org/10.1101/2022.12.05.519150
Autor:
Michael Schubert, Christy Hong, Laura J. Jilderda, Marta Requesens Rueda, Andréa E. Tijhuis, Judith E. Simon, Petra L. Bakker, Jon L. Cooper, Aristi Damaskou, René Wardenaar, Bjorn Bakker, Sahil Gupta, Anouk van den Brink, Lorena Andrade Ruiz, Miriam H. Koster, Sameh A. Youssef, Danielle Luinenburg, Alex Strong, Thomas Engleitner, Hannes Ponstingl, Gerald de Haan, Alain de Bruin, Roland Rad, Hans W. Nijman, René H. Medema, Marcel A.T.M. van Vugt, Marco de Bruyn, Diana C.J. Spierings, Maria Colomé-Tatché, George S. Vassiliou, Floris Foijer
Chromosomal instability is a hallmark of cancer, but also an instigator of aneuploidy-induced stress, reducing cellular fitness. To better understand how cells with CIN adjust to aneuploidy and adopt a malignant fate in vivo, we performed a genome-wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::527f121bf935bcd0b7fa19d39b8526ff
https://doi.org/10.1101/2021.12.03.471107
https://doi.org/10.1101/2021.12.03.471107
Autor:
Jonas Seiler, Marin T Mondria, Irena Bockaj, Marcel A. T. M. van Vugt, Bjorn Bakker, Diana C.J. Spierings, Femke Ringnalda, Saskia L Meuleman, Mathilde J.C. Broekhuis, Ulrich Schüller, Floris Foijer, Hans Clevers, Colin Stok, Tosca. E. I. Martini, Eduardo Sabino de Camargo Magalhães, Hilda van den Bos, Yannick P Kok, Tiny G. J. Meeuwsen-de Boer, Inna Armandari, René Wardenaar, Petra L. Bakker, Sophia W.M. Bruggeman
Publikováno v:
PLoS Genetics, Vol 17, Iss 11 (2021)
PLoS Genetics, 17(11). Public Library of Science
PLoS genetics, 17(11):1009868. PUBLIC LIBRARY SCIENCE
PLoS Genetics, Vol 17, Iss 11, p e1009868 (2021)
Bočkaj, I, Martini, T E I, de Camargo Magalhães, E S, Bakker, P L, Meeuwsen-de Boer, T G J, Armandari, I, Meuleman, S L, Mondria, M T, Stok, C, Kok, Y P, Bakker, B, Wardenaar, R, Seiler, J, Broekhuis, M J C, van den Bos, H, Spierings, D C J, Ringnalda, F C A, Clevers, H, Schüller, U, van Vugt, M A T M, Foijer, F & Bruggeman, S W M 2021, ' The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma ', PLoS Genetics, vol. 17, no. 11, e1009868, pp. e1009868 . https://doi.org/10.1371/journal.pgen.1009868
PLoS Genetics, 17(11):e1009868. Public Library of Science
PLoS Genetics
PLoS Genetics, 17(11). Public Library of Science
PLoS genetics, 17(11):1009868. PUBLIC LIBRARY SCIENCE
PLoS Genetics, Vol 17, Iss 11, p e1009868 (2021)
Bočkaj, I, Martini, T E I, de Camargo Magalhães, E S, Bakker, P L, Meeuwsen-de Boer, T G J, Armandari, I, Meuleman, S L, Mondria, M T, Stok, C, Kok, Y P, Bakker, B, Wardenaar, R, Seiler, J, Broekhuis, M J C, van den Bos, H, Spierings, D C J, Ringnalda, F C A, Clevers, H, Schüller, U, van Vugt, M A T M, Foijer, F & Bruggeman, S W M 2021, ' The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma ', PLoS Genetics, vol. 17, no. 11, e1009868, pp. e1009868 . https://doi.org/10.1371/journal.pgen.1009868
PLoS Genetics, 17(11):e1009868. Public Library of Science
PLoS Genetics
While comprehensive molecular profiling of histone H3.3 mutant pediatric high-grade glioma has revealed extensive dysregulation of the chromatin landscape, the exact mechanisms driving tumor formation remain poorly understood. Since H3.3 mutant gliom
Autor:
Christy, Hong, Michael, Schubert, Andréa E, Tijhuis, Marta, Requesens, Maurits, Roorda, Anouk, van den Brink, Lorena Andrade, Ruiz, Petra L, Bakker, Tineke, van der Sluis, Wietske, Pieters, Mengting, Chen, René, Wardenaar, Bert, van der Vegt, Diana C J, Spierings, Marco, de Bruyn, Marcel A T M, van Vugt, Floris, Foijer
Publikováno v:
Nature. 607(7918)
Chromosomal instability (CIN) drives cancer cell evolution, metastasis and therapy resistance, and is associated with poor prognosis
Autor:
Maurits Roorda, Michael Schubert, Petra L. Bakker, Michael Chang, Marcel A. T. M. van Vugt, Bjorn Bakker, Lin Zhou, Judith E Simon, Hinke G. Kazemier, Fernando R. Rosas Bringas, Siqi Zheng, Floris Foijer
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 12 (2021)
G3 : Genes, Genomes, Genetics, 11(12):335. GENETICS SOCIETY AMERICA
G3: Genes|Genomes|Genetics
G3 : Genes, Genomes, Genetics, 11(12):335. GENETICS SOCIETY AMERICA
G3: Genes|Genomes|Genetics
Maternal embryonic leucine zipper kinase (MELK) is frequently overexpressed in cancer, but the role of MELK in cancer is still poorly understood. MELK was shown to have roles in many cancer-associated processes including tumor growth, chemotherapy re
Autor:
Michael Schubert, Bjorn Bakker, Fernando R. Rosas Bringas, Siqi Zheng, Floris Foijer, Petra L. Bakker, Lin Zhou, Maurits Roorda, Hinke G. Kazemier, Marcel A. T. M. van Vugt, Michael Chang, Judith E Simon
Maternal embryonic leucine zipper kinase (MELK) is frequently overexpressed in cancer, but the role of MELK in cancer is still poorly understood. MELK was shown to have roles in many cancer-associated processes including tumor growth, chemotherapy re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99e37de8eaf5215e410df674114149d3
https://doi.org/10.1101/2021.07.16.452653
https://doi.org/10.1101/2021.07.16.452653