Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Petra Kukkaro"'
Autor:
Tjalf Ziemssen, Douglas L. Arnold, Enrique Alvarez, Anne H. Cross, Roman Willi, Bingbing Li, Petra Kukkaro, Harald Kropshofer, Krishnan Ramanathan, Martin Merschhemke, Bernd Kieseier, Wendy Su, Dieter A. Häring, Stephen L. Hauser, Ludwig Kappos, Jens Kuhle
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
ObjectiveThis study aims to confirm the prognostic value of baseline serum neurofilament light chain (sNfL) for on-study disease activity and worsening in patients with relapsing MS (RMS).BackgroundPrevious post-hoc studies suggested that sNfL could
Externí odkaz:
https://doaj.org/article/6738fae8633d4bd7946601c33379a1d1
Autor:
Hongping Dong, David C Chang, Maggie Ho Chia Hua, Siew Pheng Lim, Yok Hian Chionh, Fabian Hia, Yie Hou Lee, Petra Kukkaro, Shee-Mei Lok, Peter C Dedon, Pei-Yong Shi
Publikováno v:
PLoS Pathogens, Vol 8, Iss 4, p e1002642 (2012)
RNA modification plays an important role in modulating host-pathogen interaction. Flavivirus NS5 protein encodes N-7 and 2'-O methyltransferase activities that are required for the formation of 5' type I cap (m(7)GpppAm) of viral RNA genome. Here we
Externí odkaz:
https://doaj.org/article/319dc46e5a4a4f669220e31c9c81e52e
Autor:
Shee-Mei Lok, Joshua M Costin, Yancey M Hrobowski, Andrew R Hoffmann, Dawne K Rowe, Petra Kukkaro, Heather Holdaway, Paul Chipman, Krystal A Fontaine, Michael R Holbrook, Robert F Garry, Victor Kostyuchenko, William C Wimley, Sharon Isern, Michael G Rossmann, Scott F Michael
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50995 (2012)
Dengue virus infects approximately 100 million people annually, but there is no available therapeutic treatment. The mimetic peptide, DN59, consists of residues corresponding to the membrane interacting, amphipathic stem region of the dengue virus en
Externí odkaz:
https://doaj.org/article/bdc87599a35e4f68be5cecd625da32e3
Autor:
Enrique Alvarez, Jens Kuhle, Ludwig Kappos, Tjalf Ziemssen, Douglas Arnold, Anne Cross, Ibolya Boer, Ayan Das Gupta, Xixi Hu, Petra Kukkaro, Bernd Kieseier, Ronald Zielman, Stephen Hauser
Publikováno v:
Monday, April 24.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2268d37d21c66ddcaa9be7b4f3091680
https://doi.org/10.1212/wnl.0000000000203102
https://doi.org/10.1212/wnl.0000000000203102
Autor:
Luis Abrishamian, Marc Bonten, Richa Chandra, Damodaran Solai Elango, Pierre Fustier, Kinfemichael Gedif, Susana Goncalves, Awawu Igbinadolor, Jeff Kingsley, Charles G Knutson, Petra Kukkaro, Nagalingeswaran Kumarasamy, Philippe Legenne, Martha Mekebeb-Reuter, Krishnan Ramanathan, Evgeniya Reshetnyak, Michael Robinson, Jennifer Rosa, Marianne Soergel, Vaia Stavropoulou, Nina Stojcheva, Michael T Stumpp, Andreas Tietz, Xiaojun Zhao, Zhaojie Zhang
Publikováno v:
Open Forum Infectious Diseases. 9
Background Ensovibep is a multi-specific DARPin (designed ankyrin repeat protein) antiviral in clinical development for treatment of COVID-19. In the Phase 2 EMPATHY study, ensovibep demonstrated greater viral load decline versus placebo. Here we rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bf0d7915d759c7edfda66906da2a1ac
https://doi.org/10.1093/ofid/ofac492.969
https://doi.org/10.1093/ofid/ofac492.969
Autor:
Lukas B. Tanner, Xue Li Guan, Sumarlin Lee, Petra Kukkaro, Yin Hoe Yau, Susana Geifman Shochat, Pei Yong Shi, Vernon Seow, Markus R. Wenk, Guntur Fibriansah, Shee-Mei Lok, Qian Zhang, Goran Biuković, Cornelia Hunke, Pau Ling Chew, Gerhard Grüber
Publikováno v:
Journal of Biological Chemistry. 287:40525-40534
Dengue virus surface proteins, envelope (E) and pre-membrane (prM), undergo rearrangement during the maturation process at acidic condition.prM-stem region binds tighter to both E protein and lipid membrane when environment becomes acidic.At acidic c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e412600992f6c587ee001806f9c9ec71
https://doi.org/10.1074/jbc.m112.384446
https://doi.org/10.1074/jbc.m112.384446
Autor:
Gang Zou, Shee-Mei Lok, Brendon J. Hanson, Petra Kukkaro, Pei Yong Shi, Jowin K. W. Ng, Paul A. MacAry, Sylvie Alonso, Grace K. Tan
Publikováno v:
Antiviral Research. 95:216-223
The four serotypes of dengue virus (DENV) are the causative agents of the most prevalent mosquito-borne viral disease in human. No clinically approved antiviral therapy is currently available. Therapeutic antibodies represent a viable approach for po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::601f422fa4fb99b5a938576f35b7cc4e
https://doi.org/10.1016/j.antiviral.2012.06.010
https://doi.org/10.1016/j.antiviral.2012.06.010
Autor:
Petra Kukkaro, Dennis H. Bamford
Publikováno v:
Environmental Microbiology Reports. 1:71-77
Although high-salt environments are rich in viruses, virus-host interactions have not been much explored. Here we study the virus-host interactions occurring in a variety of salt environments, up to saturated salinity. We chose viruses from different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c7f5bcf7d706d564b398a12a1a331bf
https://doi.org/10.1111/j.1758-2229.2008.00007.x
https://doi.org/10.1111/j.1758-2229.2008.00007.x
Autor:
Ramesh Jadi, Victor A. Kostyuchenko, Ruklanthi de Alwis, Joanne L. Tan, Aravinda M. de Silva, Thiam Seng Ng, Petra Kukkaro, Guntur Fibriansah, James E. Crowe, Shee-Mei Lok, Scott A. Smith
Publikováno v:
Nature Communications
Dengue virus (DENV) infects ~400 million people annually. There is no licensed vaccine or therapeutic drug. Only a small fraction of the total DENV-specific antibodies in a naturally occurring dengue infection consists of highly neutralizing antibodi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::997e1fb79b5dcc3e9288e0d7df629b8b
https://pubmed.ncbi.nlm.nih.gov/25698059
https://pubmed.ncbi.nlm.nih.gov/25698059
Autor:
Yancey M. Hrobowski, Robert F. Garry, Victor A. Kostyuchenko, Scott F. Michael, Andrew R. Hoffmann, Joshua M. Costin, Sharon Isern, Shee-Mei Lok, Dawne K. Rowe, Petra Kukkaro, Krystal A. Fontaine, Michael R. Holbrook, Paul R. Chipman, William C. Wimley, Heather A. Holdaway, Michael G. Rossmann
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50995 (2012)
PLoS ONE
PLoS ONE
Dengue virus infects approximately 100 million people annually, but there is no available therapeutic treatment. The mimetic peptide, DN59, consists of residues corresponding to the membrane interacting, amphipathic stem region of the dengue virus en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ba3ba1d9a5613319eda062be028ed02
http://europepmc.org/articles/PMC3511436?pdf=render
http://europepmc.org/articles/PMC3511436?pdf=render