Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Petra Kukanja"'
Autor:
Markus M. Hilscher, Christoffer Mattsson Langseth, Petra Kukanja, Chika Yokota, Mats Nilsson, Gonçalo Castelo-Branco
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-18 (2022)
Abstract Background Oligodendrocytes are glial cells that support and insulate axons in the central nervous system through the production of myelin. Oligodendrocytes arise throughout embryonic and early postnatal development from oligodendrocyte prec
Externí odkaz:
https://doaj.org/article/8ebec61e086345adbd3180bca6c5fb7d
Autor:
Elisa M. Floriddia, Tânia Lourenço, Shupei Zhang, David van Bruggen, Markus M. Hilscher, Petra Kukanja, João P. Gonçalves dos Santos, Müge Altınkök, Chika Yokota, Enric Llorens-Bobadilla, Sara B. Mulinyawe, Mário Grãos, Lu O. Sun, Jonas Frisén, Mats Nilsson, Gonçalo Castelo-Branco
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The oligodendrocyte lineage is known for its transcriptional heterogeneity, but the functional consequences of this are unclear. Here, the authors show that distinct populations of mature oligodendrocytes have spatial preferences in the brain and spi
Externí odkaz:
https://doaj.org/article/ece367487961471eb842a80b9dcd6fef
Autor:
Marie Leoz, Petra Kukanja, Zeping Luo, Fang Huang, Daniele C Cary, B Matija Peterlin, Koh Fujinaga
Publikováno v:
PLoS Pathogens, Vol 14, Iss 11, p e1007402 (2018)
Transcription of HIV provirus is a key step of the viral cycle, and depends on the recruitment of the cellular positive transcription elongation factor b (P-TEFb) to the HIV promoter. The viral transactivator Tat can displace P-TEFb from the 7SK smal
Externí odkaz:
https://doaj.org/article/f54a35e94d4f40aaa8d6e0d215ff042d
Autor:
Di Zhang, Yanxiang Deng, Petra Kukanja, Eneritz Agirre, Marek Bartosovic, Mingze Dong, Cong Ma, Sai Ma, Graham Su, Shuozhen Bao, Yang Liu, Yang Xiao, Gorazd B. Rosoklija, Andrew J. Dwork, J. John Mann, Kam W. Leong, Maura Boldrini, Liya Wang, Maximilian Haeussler, Benjamin J. Raphael, Yuval Kluger, Gonçalo Castelo-Branco, Rong Fan
Publikováno v:
Nature. 616:113-122
Emerging spatial technologies, including spatial transcriptomics and spatial epigenomics, are becoming powerful tools for profiling of cellular states in the tissue context1–5. However, current methods capture only one layer of omics information at
Autor:
Rong Fan, Di Zhang, Yanxiang Deng, Petra Kukanja, Marek Bartosovic, Graham Su, Shuozhen Bao, Yang Liu, Yang Xiao, Sai Ma, Gorazd Rosoklija, Andrew Dowrk, J. Mann, Kam Leong, Maura Boldrini, Goncalo Castelo-Branco
Emerging spatial technologies including spatial transcriptomics and spatial epigenomics are becoming powerful tools for profiling cellular states in the tissue context. However, current methods capture only one layer of omics information at a time pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4a4f76501f67669de9aba847e48186a
https://doi.org/10.21203/rs.3.rs-1728747/v1
https://doi.org/10.21203/rs.3.rs-1728747/v1
Autor:
Will Macnair, Daniela Calini, Eneritz Agirre, Julien Bryois, Sarah Jäkel, Petra Kukanja, Nadine Stokar-Regenscheit, Virginie Ott, Lynette C. Foo, Ludovic Collin, Sven Schippling, Eduard Urich, Erik Nutma, Manuel Marzin, Sandra Amor, Roberta Magliozzi, Elyas Heidari, Mark D. Robinson, Charles ffrench-Constant, Gonçalo Castelo-Branco, Anna Williams, Dheeraj Malhotra
The lack of understanding as to the cellular and molecular basis of clinical and genetic heterogeneity in progressive multiple sclerosis (MS) has hindered the search for new effective therapies and biomarkers. Here, to address this gap, we analysed 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82ac11ba9c2fd8f4a2ebc946257f7694
https://doi.org/10.1101/2022.04.06.487263
https://doi.org/10.1101/2022.04.06.487263
Autor:
Yanxiang Deng, Marek Bartosovic, Petra Kukanja, Di Zhang, Yang Liu, Graham Su, Archibald Enninful, Zhiliang Bai, Gonçalo Castelo-Branco, Rong Fan
Publikováno v:
Science
Spatial omics emerged as a new frontier of biological and biomedical research. Here, we present spatial-CUT&Tag for spatially resolved genome-wide profiling of histone modifications by combining in situ CUT&Tag chemistry, microfluidic deterministic b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5e3fd5468ec4293b6aaff8e4f049a9b
https://europepmc.org/articles/PMC7612972/
https://europepmc.org/articles/PMC7612972/
Autor:
Yanxiang Deng, Marek Bartosovic, Sai Ma, Di Zhang, Petra Kukanja, Yang Xiao, Graham Su, Yang Liu, Xiaoyu Qin, Gorazd B. Rosoklija, Andrew J. Dwork, J. John Mann, Mina L. Xu, Stephanie Halene, Joseph E. Craft, Kam W. Leong, Maura Boldrini, Gonçalo Castelo-Branco, Rong Fan
Publikováno v:
Nature. 609(7926)
Cellular function in tissue is dependent on the local environment, requiring new methods for spatial mapping of biomolecules and cells in the tissue context1. The emergence of spatial transcriptomics has enabled genome-scale gene expression mapping2
Autor:
David van Bruggen, Fabio Pohl, Christoffer Mattsson Langseth, Petra Kukanja, Hower Lee, Alejandro Mossi Albiach, Mukund Kabbe, Mandy Meijer, Sten Linnarsson, Markus M. Hilscher, Mats Nilsson, Erik Sundström, Gonçalo Castelo-Branco
Publikováno v:
Developmental cell. 57(11)
Oligodendrogenesis in the human central nervous system has been observed mainly at the second trimester of gestation, a much later developmental stage compared to oligodendrogenesis in mice. Here, we characterize the transcriptomic neural diversity i
Autor:
Jonas Frisén, David van Bruggen, Shupei Zhang, Chika Yokota, Sara B. Mulinyawe, Markus M. Hilscher, Petra Kukanja, Muge Altinkok, Elisa M. Floriddia, Enric Llorens-Bobadilla, João P. Gonçalves dos Santos, Mats Nilsson, Mário Grãos, Lu O. Sun, Gonçalo Castelo-Branco, Tânia Lourenço
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Mature oligodendrocytes (MOLs) show transcriptional heterogeneity, the functional consequences of which are unclear. MOL heterogeneity might correlate with the local environment or their interactions with different neuron types. Here, we show that di