Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Petra Kueppers"'
Publikováno v:
Journal of Biotechnology. 191:158-164
Overexpression and purification of membrane proteins has been a bottleneck for their functional and structural study for a long time. Both homologous and heterologous expression of membrane proteins with suitable tags for purification presents unique
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16a3bf819ed17e37a53f01addb386b26
https://doi.org/10.1016/j.jbiotec.2014.07.010
https://doi.org/10.1016/j.jbiotec.2014.07.010
Publikováno v:
Journal of Biological Chemistry. 289:15272-15279
Pdr5 is a plasma membrane-bound ABC transporter from Saccharomyces cerevisiae and is involved in the phenomenon of resistance against xenobiotics, which are clinically relevant in bacteria, fungi, and humans. Many fungal ABC transporters such as Pdr5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::011a974fe6c1928ca895e7c650bad809
https://doi.org/10.1074/jbc.m114.553065
https://doi.org/10.1074/jbc.m114.553065
Publikováno v:
FEBS Journal. 277:540-549
Multidrug resistance is a major challenge in the therapy of cancer and pathogenic fungal infections. More than three decades ago, P-glycoprotein was the first identified multidrug transporter. It has been studied extensively at the genetic and bioche
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8cba4fb0ed4553f5248d44a06be769d
https://doi.org/10.1111/j.1742-4658.2009.07485.x
https://doi.org/10.1111/j.1742-4658.2009.07485.x
Publikováno v:
Biological Chemistry. 392
A subset of the family of ATP-binding cassette (ABC) transporters has been in focus owing to their involvement in conferring multidrug resistance in cancer cells and among immune compromised individuals. Saccharomyces cerevisiae is protected against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e4b783a5afb81eccc322e9305ce65d0
https://doi.org/10.1515/bc.2011.011
https://doi.org/10.1515/bc.2011.011
Autor:
Karl Kuchler, Tobias Schwarzmueller, Lutz Schmitt, Cornelia Klein, Robert K. Ernst, Petra Kueppers
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 105(13)
The yeast ABC transporter Pdr5 plays a major role in drug resistance against a large number of structurally unrelated compounds. Although Pdr5 has been extensively studied, many important aspects regarding its molecular mechanisms remain unresolved.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4262b1c87e9068df2cb8c4dd2d41d05
https://pubmed.ncbi.nlm.nih.gov/18356296
https://pubmed.ncbi.nlm.nih.gov/18356296