Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Petra Krafcikova"'
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
SARS-CoV-2 expresses a 2′-O RNA methyltransferase (MTase) that is involved in the viral RNA cap formation and therefore a target for antiviral therapy. Here the authors provide the structure of nsp10-nsp16 with the panMTase inhibitor sinefungin and
Externí odkaz:
https://doaj.org/article/56b68d24fa284e44a0da700bbd0bc2ff
Autor:
Roberto Benoni, Petra Krafcikova, Marek R. Baranowski, Joanna Kowalska, Evzen Boura, Hana Cahová
Publikováno v:
Viruses, Vol 13, Iss 9, p 1722 (2021)
The ongoing COVID-19 pandemic exemplifies the general need to better understand viral infections. The positive single-strand RNA genome of its causative agent, the SARS coronavirus 2 (SARS-CoV-2), encodes all viral enzymes. In this work, we focused o
Externí odkaz:
https://doaj.org/article/66a5d6f0269d4170a567034a04edbd4f
Autor:
Vladimira Horova, Barbora Landova, Jan Hodek, Karel Chalupsky, Petra Krafcikova, Dominika Chalupska, Vojtech Duchoslav, Jan Weber, Evzen Boura, Martin Klima
Publikováno v:
Viruses, Vol 13, Iss 8, p 1487 (2021)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the coronavirus disease-19 pandemic. One of the key components of the coronavirus replication complex are the RNA methyltransferases (MTases), RNA-modifying enzyme
Externí odkaz:
https://doaj.org/article/3beeeef5e93940659d181dfbb4333ecf
Autor:
Kateřina Krejčová, Petra Krafcikova, Martin Klima, Dominika Chalupska, Karel Chalupsky, Eva Zilecka, Evzen Boura
Flaviviruses are single-stranded positive-sense RNA (+RNA) viruses that are responsible for several (re)emerging diseases such as Yellow, Dengue or West Nile fevers. The Zika epidemic highlighted their dangerousness when a relatively benign virus kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::830f8ec44e306c79f175c80c18590afe
https://doi.org/10.1101/2023.05.03.539197
https://doi.org/10.1101/2023.05.03.539197
Autor:
Radim Nencka, Jan Silhan, Martin Klima, Tomas Otava, Hugo Kocek, Petra Krafcikova, Evzen Boura
Publikováno v:
Nucleic Acids Research
Coronaviral methyltransferases (MTases), nsp10/16 and nsp14, catalyze the last two steps of viral RNA-cap creation that takes place in cytoplasm. This cap is essential for the stability of viral RNA and, most importantly, for the evasion of innate im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd0d5179f136e6070bf4ec544ac32ee7
http://europepmc.org/articles/PMC8789044
http://europepmc.org/articles/PMC8789044
Autor:
Milan Stefek, Dominika Chalupska, Karel Chalupsky, Michala Zgarbova, Alexandra Dvorakova, Petra Krafcikova, Alice Shi Ming Li, Michal Sala, Milan Dejmek, Tomas Otava, Ema Chaloupecka, Masoud Vedadi, Jan Weber, Helena Mertlikova-Kaiserova, Radim Nencka
The search for new drugs against COVID-19 and its causative agent, SARS-CoV-2, is one of the major trends in current medicinal chemistry. Targeting capping machinery could be one of therapeutic concepts based on a unique mechanism of action. Viral RN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61709b4e2a5ebe4eade70467e7deb74d
https://doi.org/10.26434/chemrxiv-2023-ltv7l
https://doi.org/10.26434/chemrxiv-2023-ltv7l
Autor:
Petra Krafcikova, Dominika Chalupska, Karel Chalupsky, Evzen Boura, Martin Klima, Jan Weber, Vladimira Horova, Jan Hodek, Barbora Landova, Vojtech Duchoslav
Publikováno v:
Viruses; Volume 13; Issue 8; Pages: 1487
Viruses, Vol 13, Iss 1487, p 1487 (2021)
Viruses
Viruses, Vol 13, Iss 1487, p 1487 (2021)
Viruses
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the coronavirus disease-19 pandemic. One of the key components of the coronavirus replication complex are the RNA methyltransferases (MTases), RNA-modifying enzyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6172ef0b206b7089a066fb93a225949
Autor:
Dominika Chalupska, Karel Chalupsky, Jan Silhan, Evzen Boura, Jan Kozic, Petra Krafcikova, Pavel Dostalik
Publikováno v:
J Virol
The OC43 coronavirus is a human pathogen that usually causes only the common cold. One of its key enzymes, similar to other coronaviruses, is the 2'-O-RNA methyltransferase (MTase), which is essential for viral RNA stability and expression. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::586c8a2da7114240659672c78f25480a
https://europepmc.org/articles/PMC8274614/
https://europepmc.org/articles/PMC8274614/
The OC43 coronavirus is a human pathogen that usually causes only the common cold. One of its key enzymes, similar to other coronaviruses, is the 2′-O-RNA methyltransferase (MTase) that is essential for viral RNA stability and expression. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::018e005b9b97dac37422a2585ef3ff79
https://doi.org/10.1101/2021.03.16.435745
https://doi.org/10.1101/2021.03.16.435745
Autor:
Federico Gulluni, Lorenzo Prever, Huayi Li, Petra Krafcikova, Ilaria Corrado, Wen-Ting Lo, Jean Piero Margaria, Anlu Chen, Maria Chiara De Santis, Sophie J. Cnudde, Joseph Fogerty, Alex Yuan, Alberto Massarotti, Nasrin Torabi Sarijalo, Oscar Vadas, Roger L. Williams, Marcus Thelen, David R. Powell, Markus Schueler, Michael S. Wiesener, Tamas Balla, Hagit N. Baris, Dov Tiosano, Brian M. McDermott, Brian D. Perkins, Alessandra Ghigo, Miriam Martini, Volker Haucke, Evzen Boura, Giorgio Roberto Merlo, David A. Buchner, Emilio Hirsch
Publikováno v:
Science
Cytokinetic membrane abscission is a spatially and temporally regulated process that requires ESCRT (endosomal sorting complexes required for transport)-–dependent control of membrane remodeling at the midbody, a subcellular organelle that defines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13b7b8e4bf586cb0f98e5fc0fb47473f
http://hdl.handle.net/2318/1831621
http://hdl.handle.net/2318/1831621