Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Petra Kovaříková"'
Autor:
Eliška Potůčková, Jaroslav Roh, Miloslav Macháček, Sumit Sahni, Ján Stariat, Vít Šesták, Hana Jansová, Pavlína Hašková, Anna Jirkovská, Kateřina Vávrová, Petra Kovaříková, Danuta S Kalinowski, Des R Richardson, Tomáš Šimůnek
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0139929 (2015)
Cancer cells have a high iron requirement and many experimental studies, as well as clinical trials, have demonstrated that iron chelators are potential anti-cancer agents. The ligand, 2-benzoylpyridine 4-ethyl-3-thiosemicarbazone (Bp4eT), demonstrat
Externí odkaz:
https://doaj.org/article/32e0e5c048be40ea9b144abca457a50c
Autor:
Eliška Potůčková, Kateřina Hrušková, Jan Bureš, Petra Kovaříková, Iva A Špirková, Kateřina Pravdíková, Lucie Kolbabová, Tereza Hergeselová, Pavlína Hašková, Hana Jansová, Miloslav Macháček, Anna Jirkovská, Vera Richardson, Darius J R Lane, Danuta S Kalinowski, Des R Richardson, Kateřina Vávrová, Tomáš Šimůnek
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112059 (2014)
Salicylaldehyde isonicotinoyl hydrazone (SIH) is a lipophilic, tridentate iron chelator with marked anti-oxidant and modest cytotoxic activity against neoplastic cells. However, it has poor stability in an aqueous environment due to the rapid hydroly
Externí odkaz:
https://doaj.org/article/75379cfa306d4b7089a5881bf026ec6f
Autor:
Kateřina Vávrová, Kateřina Hrušková, Tereza Hergeselová, Eliška Potůčková, Lukáš Opálka, Petra Kovaříková, Pavlína Hašková, Tomáš Šimůnek
Publikováno v:
Chemical Research in Toxicology. 31:435-446
Aroylhydrazone iron chelators such as salicylaldehyde isonicotinoyl hydrazone (SIH) protect various cells against oxidative injury and display antineoplastic activities. Previous studies have shown that a nitro-substituted hydrazone, namely, NHAPI, d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51c1672ade1dc7582ed4e3d8617385ba
https://doi.org/10.1021/acs.chemrestox.7b00324
https://doi.org/10.1021/acs.chemrestox.7b00324
Autor:
Tomáš Šimůnek, Petra Reimerová, Petra Kovaříková, Hana Jansová, Jan Bures, Eduard Jirkovský, Lucie Vostatkova, Anna Jirkovská-Vávrová, Olga Lenčová-Popelová, Yvona Mazurová, Milos Hroch, Michaela Adamcova, Zuzana Pokorná, Martin Štěrba
Publikováno v:
Toxicology. 372:52-63
Chronic anthracycline (ANT) cardiotoxicity is a serious complication of cancer chemotherapy. Molsidomine, a NO-releasing drug, has been found cardioprotective in different models of I/R injury and recently in acute high-dose ANT cardiotoxicity. Hence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53387911a3c092fba1bf6a5566c53800
https://doi.org/10.1016/j.tox.2016.11.002
https://doi.org/10.1016/j.tox.2016.11.002
Autor:
Tomáš Šimůnek, Miloslav Machacek, Katherine J. Franz, Anna Jirkovská, Jan Bures, Petra Kovaříková, Pavlína Hašková, Hana Jansová
Publikováno v:
Toxicology. 371:17-28
Catecholamines may undergo iron-promoted oxidation resulting in formation of reactive intermediates (aminochromes) capable of redox cycling and reactive oxygen species (ROS) formation. Both of them induce oxidative stress resulting in cellular damage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a0d3e8fbb38462632ec9d6d9bcf4af
https://doi.org/10.1016/j.tox.2016.10.004
https://doi.org/10.1016/j.tox.2016.10.004
Autor:
Petra Brazdova, Jaroslav Chládek, Jaroslav Roh, Petra Kovaříková, Galina Karabanovich, Olga Lenčová, Anna Jirkovská, Martin Štěrba, Eduard Jirkovský, Zuzana Pokorná, Ján Stariat, Jan Bures, Tomáš Šimůnek
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 364(3)
Dexrazoxane (DEX), the only cardioprotectant approved against anthracycline cardiotoxicity, has been traditionally deemed to be a prodrug of the iron-chelating metabolite ADR-925. However, pharmacokinetic profile of both agents, particularly with res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb300fd38ff0eed1f56fae3293bffd6
https://pubmed.ncbi.nlm.nih.gov/29273587
https://pubmed.ncbi.nlm.nih.gov/29273587
Publikováno v:
Klinicka onkologie. 27:S22-S27
Migration and invasiveness are phenotypic characteristics of cells that contribute to physiological processes, such as wound healing or embryogenesis and they are involved in serious pathological processes, namely in tumor cell metastasis. Availabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e75af92ac022c8ba47905c5bcc832100
https://doi.org/10.14735/amko20141s22
https://doi.org/10.14735/amko20141s22
Publikováno v:
Journal of Separation Science. 37:1089-1093
Creatine, phosphocreatine, and adenine nucleotides are highly polar markers of myocardial metabolism that are poorly retained on RP silica sorbents. Zirconia represents an alternative material to silica with high promise to be used in hydrophilic int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f88b6cbb31b5d2448f51e2ad1a06c8c4
https://doi.org/10.1002/jssc.201301330
https://doi.org/10.1002/jssc.201301330
Autor:
Jaroslav Roh, Petra Kovaříková, Danuta S. Kalinowski, Ján Stariat, Vit Sestak, Tomáš Eisner, Des R. Richardson, Jiří Klimeš, Milan Nobilis, Přemysl Mladěnka, Tomáš Šimůnek, Vlasta Suprunová, Tomáš Filipský
Publikováno v:
Biomedical Chromatography. 28:621-629
Novel thiosemicarbazone metal chelators are extensively studied anti-cancer agents with marked and selective activity against a wide variety of cancer cells, as well as human tumor xenografts in mice. This study describes the first validated LC-MS/MS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::639f8d1426a739b23c67a98b6d254f18
https://doi.org/10.1002/bmc.3080
https://doi.org/10.1002/bmc.3080
Autor:
Olga Popelová, Petra Kovaříková, Vladimír Geršl, Tomáš Šimůnek, Martin Štěrba, Eduard Jirkovský, Anna Vávrová
Publikováno v:
Antioxidants & Redox Signaling. 18:899-929
Significance: Anthracyclines (doxorubicin, daunorubicin, or epirubicin) rank among the most effective anticancer drugs, but their clinical usefulness is hampered by the risk of cardiotoxicity. The most feared are the chronic forms of cardiotoxicity,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eed9b5d183c9cb1e350ee53bf2b969dc
https://doi.org/10.1089/ars.2012.4795
https://doi.org/10.1089/ars.2012.4795