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pro vyhledávání: '"Petra Igličar"'
Autor:
Nataša Nagelj Kovačič, Uroš Urleb, Andrej Preželj, Jurij Trontelj, Igor Locatelli, Samo Andrenšek, Petra Igličar, Aleš Mrhar
Publikováno v:
Chromatographia. 70:1103-1112
Multiple-species plasma-stability testing and pharmacokinetic studies in rats and dogs were performed on LK-157, a novel 10-ethylidene tricyclic carbapenem and potent inactivator of β-lactamases of classes A, C, and D. An LC–MS–MS method was dev
Publikováno v:
Journal of Pharmacy and Pharmacology. 61:1211-1218
Publikováno v:
Journal of Pharmacy and Pharmacology. 61:1211-1218
Objectives LK-157 is a novel 10-ethylidene tricyclic carbapenem that resembles the structure of the broad-spectrum antibiotic sanfetrinem and acts as a potent inactivator of β-lactamases of classes A, C and D. LK-157 is a highly soluble but poorly p