Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Petra Hundehege"'
Autor:
Christina B. Schroeter, Leoni Rolfes, K. S. Sophie Gothan, Joel Gruchot, Alexander M. Herrmann, Stefanie Bock, Luca Fazio, Antonia Henes, Venu Narayanan, Steffen Pfeuffer, Christopher Nelke, Saskia Räuber, Niklas Huntemann, Eduardo Duarte-Silva, Vera Dobelmann, Petra Hundehege, Heinz Wiendl, Katharina Raba, Patrick Küry, David Kremer, Tobias Ruck, Thomas Müntefering, Thomas Budde, Manuela Cerina, Sven G. Meuth
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-19 (2022)
Abstract Background Cladribine is a synthetic purine analogue that interferes with DNA synthesis and repair next to disrupting cellular proliferation in actively dividing lymphocytes. The compound is approved for the treatment of multiple sclerosis (
Externí odkaz:
https://doaj.org/article/58f69881c3e94968a5c457db1a7af330
Autor:
Felix Glaser, Petra Hundehege, Etmar Bulk, Luca Matteo Todesca, Sandra Schimmelpfennig, Elke Nass, Thomas Budde, Sven G. Meuth, Albrecht Schwab
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Non-small cell lung cancer (NSCLC) has a poor prognosis with a 5 year survival rate of only ~ 10%. Important driver mutations underlying NSCLC affect the epidermal growth factor receptor (EGFR) causing the constitutive activation of its tyro
Externí odkaz:
https://doaj.org/article/ea44233d01d54406b574d27a85bdab53
Publikováno v:
Cellular Physiology and Biochemistry, Vol 55, Iss S3, Pp 145-156 (2021)
Externí odkaz:
https://doaj.org/article/69fb5c1c016f4777a93248744b69b3fa
Autor:
Manuela Cerina, Muthuraman Muthuraman, Marco Gallus, Nabin Koirala, Andre Dik, Lydia Wachsmuth, Petra Hundehege, Patrick Schiffler, Jan-Gerd Tenberge, Vinzenz Fleischer, Gabriel Gonzalez-Escamilla, Venu Narayanan, Julia Krämer, Cornelius Faber, Thomas Budde, Sergiu Groppa, Sven G. Meuth
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-16 (2020)
Abstract Background Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS), characterized by inflammatory and neurodegenerative processes. Despite demyelination being a hallmark of the disease, how it relates to neurodeg
Externí odkaz:
https://doaj.org/article/04861f764dbb4359978bce487ff0e7bf
Autor:
Petra Hundehege, Manuela Cerina, Susann Eichler, Christian Thomas, Alexander M Herrmann, Kerstin Göbel, Thomas Müntefering, Juncal Fernandez-Orth, Stefanie Bock, Venu Narayanan, Thomas Budde, Erwin-Josef Speckmann, Heinz Wiendl, Anna Schubart, Tobias Ruck, Sven G Meuth
Publikováno v:
Neural Regeneration Research, Vol 14, Iss 11, Pp 1950-1960 (2019)
Autoimmune diseases of the central nervous system (CNS) like multiple sclerosis (MS) are characterized by inflammation and demyelinated lesions in white and grey matter regions. While inflammation is present at all stages of MS, it is more pronounced
Externí odkaz:
https://doaj.org/article/047ceb78633e4f8ebf177bdbc57d621b
Autor:
Tengiz Oniani, Laura Vinnenberg, Rahul Chaudhary, Julian A. Schreiber, Kathrin Riske, Brandon Williams, Hans-Christian Pape, John A. White, Anna Junker, Guiscard Seebohm, Sven G. Meuth, Petra Hundehege, Thomas Budde, Mehrnoush Zobeiri
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 11, p 6285 (2022)
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system that is characterized by the progressive loss of oligodendrocytes and myelin and is associated with thalamic dysfunction. Cuprizone (CPZ)-induced general demyelination i
Externí odkaz:
https://doaj.org/article/9fbb2807f42e431c8bf2d65f55c70606
Autor:
Petra Hundehege, Juncal Fernandez-Orth, Pia Römer, Tobias Ruck, Thomas Müntefering, Susann Eichler, Manuela Cerina, Lisa Epping, Sarah Albrecht, Amélie F. Menke, Katharina Birkner, Kerstin Göbel, Thomas Budde, Frauke Zipp, Heinz Wiendl, Ali Gorji, Stefan Bittner, Sven G. Meuth
Publikováno v:
Neurosignals, Vol 26, Iss 1, Pp 77-93 (2018)
Background/Aims: Multiple sclerosis (MS) is a prototypical autoimmune central nervous system (CNS) disease. Particularly progressive forms of MS (PMS) show significant neuroaxonal damage as consequence of demyelination and neuronal hyperexcitation. I
Externí odkaz:
https://doaj.org/article/51ed4769974e495d9c31602ef20bb7a2
Autor:
Catharina C. Gross, Marc Pawlitzki, Andreas Schulte-Mecklenbeck, Leoni Rolfes, Tobias Ruck, Petra Hundehege, Heinz Wiendl, Michael Herty, Sven G. Meuth
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 6, p 2046 (2020)
The central nervous system (CNS) is an immune-privileged compartment that is separated from the circulating blood and the peripheral organs by the blood−brain and the blood−cerebrospinal fluid (CSF) barriers. Transmigration of lymphocyte subsets
Externí odkaz:
https://doaj.org/article/09fbc6affe7947bc9a5da76c17e726f8
Autor:
Christina B. Schroeter, Christopher Nelke, Marcus Schewe, Lucas Spohler, Alexander M. Herrmann, Thomas Müntefering, Niklas Huntemann, Maria Kuzikov, Philip Gribbon, Sarah Albrecht, Stefanie Bock, Petra Hundehege, Lea Christine Neelsen, Thomas Baukrowitz, Guiscard Seebohm, Bernhard Wünsch, Stefan Bittner, Tobias Ruck, Thomas Budde, Sven G. Meuth
Publikováno v:
Biological Chemistry. 404:355-375
Modulation of two-pore domain potassium (K2P) channels has emerged as a novel field of therapeutic strategies as they may regulate immune cell activation and metabolism, inflammatory signals, or barrier integrity. One of these ion channels is the TWI
Autor:
Lukas Gola, Laura Bierhansl, Nicolas Hummel, Lisanne Korn, Matthias Pawlowski, Manuela Cerina, Petra Hundehege, Thomas Budde, Simone König, Sven G. Meuth, Heinz Wiendl, Stjepana Kovac
Publikováno v:
Free Radical Biology and Medicine. 194:337-346
Hyperexcitability-induced neuronal damage plays a role both in epilepsy as well as in inflammatory brain diseases such as multiple sclerosis (MS) and as such represents an important disease pathway which potentially can be targeted to mitigate neuron