Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Petra Henklein"'
Autor:
Clemens Cammann, Jonas Kulla, Lüder Wiebusch, Christian Walz, Fang Zhao, Theresa Lowinus, Eylin Topfstedt, Neha Mishra, Petra Henklein, Ursula Bommhardt, Lukas Bossaller, Christian Hagemeier, Dirk Schadendorf, Boris Schmidt, Annette Paschen, Ulrike Seifert
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115635- (2023)
Primary and acquired therapy resistance is a major problem in patients with BRAF-mutant melanomas being treated with BRAF and MEK inhibitors (BRAFI, MEKi). Therefore, development of alternative therapy regimes is still required. In this regard, new d
Externí odkaz:
https://doaj.org/article/a59ff95cf70448d3b0138e944befb1de
Autor:
Charlotte Gehin, Museer A. Lone, Winston Lee, Laura Capolupo, Sylvia Ho, Adekemi M. Adeyemi, Erica H. Gerkes, Alexander P.A. Stegmann, Estrella López-Martín, Eva Bermejo-Sánchez, Beatriz Martínez-Delgado, Christiane Zweier, Cornelia Kraus, Bernt Popp, Vincent Strehlow, Daniel Gräfe, Ina Knerr, Eppie R. Jones, Stefano Zamuner, Luciano A. Abriata, Vidya Kunnathully, Brandon E. Moeller, Anthony Vocat, Samuel Rommelaere, Jean-Philippe Bocquete, Evelyne Ruchti, Greta Limoni, Marine Van Campenhoudt, Samuel Bourgeat, Petra Henklein, Christian Gilissen, Bregje W. van Bon, Rolph Pfundt, Marjolein H. Willemsen, Jolanda H. Schieving, Emanuela Leonardi, Fiorenza Soli, Alessandra Murgia, Hui Guo, Qiumeng Zhang, Kun Xia, Christina R. Fagerberg, Christoph P. Beier, Martin J. Larsen, Irene Valenzuela, Paula Fernández-Álvarez, Shiyi Xiong, Robert Śmigiel, Vanesa López-González, Lluís Armengol, Manuela Morleo, Angelo Selicorni, Annalaura Torella, Moira Blyth, Nicola S. Cooper, Valerie Wilson, Renske Oegema, Yvan Herenger, Aurore Garde, Ange-Line Bruel, Frederic Tran Mau-Them, Alexis B.R. Maddocks, Jennifer M. Bain, Musadiq A. Bhat, Gregory Costain, Peter Kannu, Ashish Marwaha, Neena L. Champaigne, Michael J. Friez, Ellen B. Richardson, Vykuntaraju K. Gowda, Varunvenkat M. Srinivasan, Yask Gupta, Tze Y. Lim, Simone Sanna-Cherchi, Bruno Lemaitre, Toshiyuki Yamaji, Kentaro Hanada, John E. Burke, Ana Marjia Jakšić, Brian D. McCabe, Paolo De Los Rios, Thorsten Hornemann, Giovanni D’Angelo, Vincenzo A. Gennarino
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 10 (2023)
Neural differentiation, synaptic transmission, and action potential propagation depend on membrane sphingolipids, whose metabolism is tightly regulated. Mutations in the ceramide transporter CERT (CERT1), which is involved in sphingolipid biosynthesi
Externí odkaz:
https://doaj.org/article/47a113198d5649e88315ddec99f2067f
Autor:
Anouk C.M. Platteel, Juliane Liepe, Kathrin Textoris-Taube, Christin Keller, Petra Henklein, Hanna H. Schalkwijk, Rebeca Cardoso, Peter M. Kloetzel, Michele Mishto, Alice J.A.M. Sijts
Publikováno v:
Cell Reports, Vol 20, Iss 5, Pp 1242-1253 (2017)
Summary: Proteasome-catalyzed peptide splicing (PCPS) generates peptides that are presented by MHC class I molecules, but because their identification is challenging, the immunological relevance of spliced peptides remains unclear. Here, we developed
Externí odkaz:
https://doaj.org/article/dbbb84c5c1774707b8e9c342d573f020
Autor:
Ankur Midha, Katharina Janek, Agathe Niewienda, Petra Henklein, Sebastian Guenther, Diego O. Serra, Josephine Schlosser, Regine Hengge, Susanne Hartmann
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
Externí odkaz:
https://doaj.org/article/45b2ee46c8b34f7e8256ca438c824cba
Autor:
Ankur Midha, Katharina Janek, Agathe Niewienda, Petra Henklein, Sebastian Guenther, Diego O. Serra, Josephine Schlosser, Regine Hengge, Susanne Hartmann
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
Ascariasis is a widespread soil-transmitted helminth infection caused by the intestinal roundworm Ascaris lumbricoides in humans, and the closely related Ascaris suum in pigs. Progress has been made in understanding interactions between helminths and
Externí odkaz:
https://doaj.org/article/fe07477f19b344b887e0c3266a6515b3
Autor:
Friedrich Hahn, Adrian Schmalen, Christian Setz, Melanie Friedrich, Stefan Schlößer, Julia Kölle, Robert Spranger, Pia Rauch, Kirsten Fraedrich, Tatjana Reif, Julia Karius-Fischer, Ashok Balasubramanyam, Petra Henklein, Torgils Fossen, Ulrich Schubert
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0174254 (2017)
There is a significantly higher risk for type II diabetes in HIV-1 carriers, albeit the molecular mechanism for this HIV-related pathology remains enigmatic. The 52 amino acid HIV-1 p6 Gag protein is synthesized as the C-terminal part of the Gag poly
Externí odkaz:
https://doaj.org/article/ff4f74b40c1748b0ba8e1d0e7fc126d2
Autor:
Izabela Mlynarczuk-Bialy, Thorsten R. Doeppner, Jakub Golab, Dominika Nowis, Grzegorz M. Wilczynski, Kamil Parobczak, Moritz E. Wigand, Malgorzata Hajdamowicz, Łukasz P. Biały, Olga Aniolek, Petra Henklein, Mathias Bähr, Boris Schmidt, Ulrike Kuckelkorn, Peter-M. Kloetzel
Publikováno v:
Translational Oncology, Vol 7, Iss 5, Pp 570-579 (2014)
Inhibition of the proteasome offers many therapeutic possibilities in inflammation as well as in neoplastic diseases. However, clinical use of proteasome inhibitors is limited by the development of resistance or severe side effects. In our study we c
Externí odkaz:
https://doaj.org/article/dac0949447534c1b883208e645e9afcb
Autor:
Friedrich Hahn, Christian Setz, Melanie Friedrich, Pia Rauch, Sara Marie Solbak, Nils Åge Frøystein, Petra Henklein, Jörg Votteler, Torgils Fossen, Ulrich Schubert
Publikováno v:
Viruses, Vol 6, Iss 10, Pp 3738-3765 (2014)
The HIV-1 p6 Gag protein contains two late assembly (l-) domains that recruit proteins of the endosomal sorting complex required for transport (ESCRT) pathway to mediate membrane fission between the nascent virion and the cell membrane. It was recent
Externí odkaz:
https://doaj.org/article/f1abba788c204694adf1a465b5253234
Autor:
Adrian Schmalen, Julia Karius-Fischer, Pia Rauch, Christian Setz, Klaus Korn, Petra Henklein, Torgils Fossen, Ulrich Schubert
Publikováno v:
Viruses, Vol 10, Iss 12, p 710 (2018)
As part of the Pr55Gag polyprotein, p6 fulfills an essential role in the late steps of the replication cycle. However, almost nothing is known about the functions of the mature HIV-1 p6 protein. Recently, we showed that p6 is a bona fide substrate of
Externí odkaz:
https://doaj.org/article/e91b4b96925e4478a6f09e72f46365f7
Autor:
Melanie Friedrich, Christian Setz, Friedrich Hahn, Alina Matthaei, Kirsten Fraedrich, Pia Rauch, Petra Henklein, Maximilian Traxdorf, Torgils Fossen, Ulrich Schubert
Publikováno v:
Viruses, Vol 8, Iss 4, p 117 (2016)
The HIV-1 Gag p6 protein regulates the final abscission step of nascent virions from the cell membrane by the action of its two late (l-) domains, which recruit Tsg101 and ALIX, components of the ESCRT system. Even though p6 consists of only 52 amino
Externí odkaz:
https://doaj.org/article/a5aa0f29422d4585a157e6d21a641618