Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Petra H.H. van den Broek"'
Publikováno v:
Current Research in Toxicology, Vol 6, Iss , Pp 100149- (2024)
Tofacitinib is a small molecule Janus kinase (JAK) inhibitor, introduced to the European market in 2017, for the treatment of rheumatoid arthritis, psoriatic arthritis and ulcerative colitis. In the treatment of women with autoimmune diseases, pregna
Externí odkaz:
https://doaj.org/article/0dd656059de5435ba0d70e631e0990d4
Autor:
Celine Bolwerk, Cecile Magis-Escurra, Wouter Hoefsloot, Laurens F. M. Verscheijden, Arjan van Laarhoven, David M. Burger, Jakko van Ingen, Jan B. Koenderink, Frans G. M. Russel, Reinout van Crevel, Rob E. Aarnoutse, Martin J. Boeree, Rovina Ruslami, Petra H.H. van den Broek, Carlijn H. C. Litjens, Lindsey H.M. te Brake, Elin M. Svensson, Jeroen J. M. W. van den Heuvel, Saskia Kuipers, Rick Greupink
Publikováno v:
Journal of Clinical Pharmacology and Journal of New Drugs, 62, 3, pp. 385-396
Journal of Clinical Pharmacology and Journal of New Drugs, 62, 385-396
Journal of Clinical Pharmacology and Journal of New Drugs, 62, 385-396
Contains fulltext : 248642.pdf (Publisher’s version ) (Open Access) Moxifloxacin has an important role in the treatment of tuberculosis (TB). Unfortunately, coadministration with the cornerstone TB drug rifampicin results in suboptimal plasma expos
Autor:
Hedwig van Hove, Maartje H Meijer, Nel Roeleveld, Jeanne Pertijs, Frans G. M. Russel, Rick Greupink, Joris van Drongelen, Gaby A M Eliesen, Petra H.H. van den Broek
Publikováno v:
Archives of Toxicology, 95, 2, pp. 557-571
Archives of Toxicology, 95, 557-571
Archives of Toxicology
Archives of Toxicology, 95, 557-571
Archives of Toxicology
The application of anticancer drugs during pregnancy is associated with placenta-related adverse pregnancy outcomes. Therefore, it is important to study placental toxicity of anticancer drugs. The aim of this study was to compare effects on viability
Autor:
Gaby A.M. Eliesen, Milou Fransen, Nina Kooijman, Petra H.H. van den Broek, Frans G.M. Russel, Rick Greupink
Publikováno v:
Toxicology in Vitro, 80
Contains fulltext : 248599.pdf (Publisher’s version ) (Open Access) Tumor necrosis factor (TNF) regulates trophoblast turnover during the formation of the placental syncytium and can be a potentially relevant target for adverse effects of xenobioti
Autor:
Melissa A.E. van de Wal, Sanne J. C. M. Frambach, Frans G. M. Russel, Jan A.M. Smeitink, Tom J.J. Schirris, Ria de Haas, Petra H.H. van den Broek
Publikováno v:
Biochimica et Biophysica Acta. Molecular Basis of Disease, 1866
Biochimica et Biophysica Acta. Molecular Basis of Disease, 1866, 6
Biochimica et Biophysica Acta. Molecular Basis of Disease, 1866, 6
Mitochondrial complex I (CI), the first multiprotein enzyme complex of the OXPHOS system, executes a major role in cellular ATP generation. Consequently, dysfunction of this complex has been linked to inherited metabolic disorders, including Leigh di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5bf0a85cfb9515d9b44cde072e06879
http://hdl.handle.net/2066/218559
http://hdl.handle.net/2066/218559
Autor:
Joris van Drongelen, Gaby A M Eliesen, Petra H.H. van den Broek, Annick de Vries, Nel Roeleveld, Nina I Kooijman, Frans G. M. Russel, Rick Greupink, Hedwig van Hove
Publikováno v:
Clinical Pharmacology and Therapeutics
Clinical Pharmacology and Therapeutics, 108, 1, pp. 99-106
Clinical Pharmacology and Therapeutics, 108, 99-106
Clinical Pharmacology and Therapeutics, 108, 1, pp. 99-106
Clinical Pharmacology and Therapeutics, 108, 99-106
Contains fulltext : 220609.pdf (Publisher’s version ) (Open Access) Tumor necrosis factor (TNF) inhibitors are increasingly applied during pregnancy without clear knowledge of the impact on placenta and fetus. We assessed placental transfer and exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76edf0c9376283d1c6575724232f27a8
https://doi.org/10.1002/cpt.1827
https://doi.org/10.1002/cpt.1827
Autor:
Petra H.H. van den Broek, Jan A.M. Smeitink, Svetlana Pecheritsyna, Pierre Eftekhari, Akkiz Bekel, Peter van Zandvoort, Julien Beyrath, Lisanne Houben, Herma Renkema, Mina Pellegrini
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Scientific Reports, 8
Scientific Reports
Scientific Reports, 8
Scientific Reports
A deficient activity of one or more of the mitochondrial oxidative phosphorylation (OXPHOS) enzyme complexes leads to devastating diseases, with high unmet medical needs. Mitochondria, and more specifically the OXPHOS system, are the main cellular pr
Autor:
Karl M. Weigand, Marola M.H. van Lipzig, Frans G. M. Russel, Sylvia Notenboom, Petra H.H. van den Broek, Geny M. M. Groothuis, Johannes H. Proost, Rick Greupink, Evita van de Steeg
Publikováno v:
European Journal of Pharmaceutical Sciences, 115, pp. 175-184
European Journal of Pharmaceutical Sciences, 115, 175-184. ELSEVIER SCIENCE BV
European Journal of Pharmaceutical Sciences, 115, 175-184
European Journal of Pharmaceutical Sciences, 115, 175-184. ELSEVIER SCIENCE BV
European Journal of Pharmaceutical Sciences, 115, 175-184
Drug-induced liver injury (DILI) is a common reason for drug withdrawal from the market. An important cause of DILI is drug-induced cholestasis. One of the major players involved in drug-induced cholestasis is the bile salt efflux pump (BSEP; ABCB11)
Autor:
Joris van Drongelen, Gaby A M Eliesen, Petra H.H. van den Broek, Albert Bilos, Rick Greupink, Jeanne Pertijs, Jeroen J. van den Heuvel, Frans G. M. Russel
Publikováno v:
Toxicological Sciences. 157:500-509
Tyrosine kinase inhibitors (TKIs) play an important role in cancer pharmacotherapy, yet there is limited data on their use during pregnancy. We studied placental disposition and placental toxicity of crizotinib, a TKI used to treat nonsmall cell lung
Autor:
Matthew R. Redinbo, Simon T.K. Yauw, Harry van Goor, Roger M. L. M. Lomme, Aadra P. Bhatt, Melissa N.N. Arron, Rick Greupink, Petra H.H. van den Broek
Publikováno v:
Surgical Infections, 19, 4, pp. 417-423
Surgical Infections, 19, 417-423
Surgical Infections, 19, 417-423
Item does not contain fulltext BACKGROUND: The non-steroidal anti-inflammatory drug diclofenac has been associated with intestinal anastomotic leakage, although the underlying pathophysiology is unclear. Previous data suggest that reactivation of bil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c3b5d9063f7a472f3daa8b57cc13221
https://hdl.handle.net/2066/193593
https://hdl.handle.net/2066/193593