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Mechanistic Insights into the Retaining Glucosyl-3-phosphoglycerate Synthase from Mycobacteria*

Autor: Ha T. Pham, Ana Carreras-González, Devinder Kaur, David Albesa-Jové, Francis Schaeffer, Sonia Lopez-Fernandez, Patrick J. Brennan, Mary Jackson, Saioa Urresti, Petra Gest, Mark J. van der Woerd, Pedro M. Alzari, Marcelo E. Guerin

Publikováno v: Journal of Biological Chemistry; Vol 287
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2012, 287 (29), pp.24649-24661. ⟨10.1074/jbc.M112.368191⟩
Journal of Biological Chemistry, 2012, 287 (29), pp.24649-24661. ⟨10.1074/jbc.M112.368191⟩

International audience; Considerable progress has been made in recent years in our understanding of the structural basis of glycosyl transfer. Yet the nature and relevance of the conformational changes associated with substrate recognition and cataly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5869feb1e8dc8707b3ff9cf7c450c221

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Rational Design, Synthesis, and Evaluation of New Selective Inhibitors of Microbial Class II (Zinc Dependent) Fructose Bis-phosphate Aldolases

Autor: Matthieu Fonvielle, Mary Jackson, Michel Therisod, Petra Gest, Racha Daher, Mathieu Coinçon, Marcelo E. Guerin, Jurgen Sygusch

Publikováno v: Journal of Medicinal Chemistry. 53:7836-7842

We report the synthesis and biochemical evaluation of several selective inhibitors of class II (zinc dependent) fructose bis-phosphate aldolases (Fba). The products were designed as transition-state analogues of the catalyzed reaction, structurally r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5166c299aa983efa7bf7dd7d99d4700b
https://doi.org/10.1021/jm1009814

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New Insights into the Early Steps of Phosphatidylinositol Mannoside Biosynthesis in Mycobacteria

Autor: Patrick J. Brennan, Sara Gibbs, Marcelo E. Guerin, Mary Jackson, B. S. Somashekar, Devinder Kaur, Petra Gest, Delphi Chatterjee

Publikováno v: Journal of Biological Chemistry. 284:25687-25696

Phosphatidyl-myo-inositol mannosides (PIMs) are key glycolipids of the mycobacterial cell envelope. They are considered not only essential structural components of the cell but also important molecules implicated in host-pathogen interactions. Althou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::138b74a8ca4727613fedcb03f0cd6fbc
https://doi.org/10.1074/jbc.m109.030593

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Substrate-induced Conformational Changes in the Essential Peripheral Membrane-associated Mannosyltransferase PimA from Mycobacteria

Autor: Mary Jackson, Pedro M. Alzari, David Giganti, Marcelo E. Guerin, Jana Korduláková, Mark J. van der Woerd, Francis Schaeffer, Alain Chaffotte, Petra Gest

Publikováno v: Journal of Biological Chemistry. 284:21613-21625

Phosphatidyl-myo-inositol mannosyltransferase A (PimA) is an essential glycosyltransferase (GT) involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIMs), which are key components of the mycobacterial cell envelope. PimA is the para

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::92fc2f5d9fb45c6b69ba332f9129557f
https://doi.org/10.1074/jbc.m109.003947

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Preliminary crystallographic analysis of GpgS, a key glucosyltransferase involved in methylglucose lipopolysaccharide biosynthesis inMycobacterium tuberculosis

Autor: Mary Jackson, Marcelo E. Guerin, Patrick J. Brennan, Ha T. Pham, Mark J. van der Woerd, Emily Hansen, Devinder Kaur, Petra Gest

Publikováno v: Acta Crystallographica Section F Structural Biology and Crystallization Communications. 64:1121-1124

Glucosyl-3-phosphoglycerate synthase (GpgS) is a key enzyme that catalyses the first glucosylation step in methylglucose lipopolysaccharide biosynthesis in mycobacteria. These important molecules are believed to be involved in the regulation of fatty

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb3e64c6e2647c4436583f6b821d2b6
https://doi.org/10.1107/s1744309108032892

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Glycolytic and Non-glycolytic Functions of Mycobacterium tuberculosis Fructose-1,6-bisphosphate Aldolase, an Essential Enzyme Produced by Replicating and Non-replicating Bacilli*

Autor: Petra Gest, Gavin J. Ryan, María de la Paz Santangelo, Dirk Schnappinger, Ha Pham, Mercedes Gonzalez-Juarrero, Sabine Ehrt, Susan E. Puckett, John S. Spencer, Racha Daher, Mathieu Coinçon, Marcelo E. Guerin, Jurgen Sygusch, Anne J. Lenaerts, Michel Therisod, Mary Jackson

The search for antituberculosis drugs active against persistent bacilli has led to our interest in metallodependent class II fructose-1,6-bisphosphate aldolase (FBA-tb), a key enzyme of gluconeogenesis absent from mammalian cells. Knock-out experimen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee1199e0fc38e3a49c7765816a52132d
https://europepmc.org/articles/PMC3220552/

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Structural basis of methylglucose lipopolysaccharide biosynthesis in mycobacteria

Autor: Patrick J. Brennan, Mary Jackson, Ha T. Pham, S.L. Fernandez, Petra Gest, Saioa Urresti, A.C. Gonzalez, Francis Schaeffer, David Albesa-Jové, Marcelo E. Guerin, Pedro M. Alzari, M. van der Woerd

Publikováno v: Acta Crystallographica Section A Foundations of Crystallography. 67:C789-C790

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65b9c2f7272fc35fe8e3874947fd5a93
https://doi.org/10.1107/s0108767311080019

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