Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Petra D Cravens"'
Autor:
Petra D Cravens, Rehana Z Hussain, William A Miller-Little, Li-Hong Ben, Benjamin M Segal, Emily Herndon, Olaf Stüve
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0165248 (2016)
Interleukin (IL)-12 and IL-23 are heterodimers that share the p40 subunit, and both cytokines are critical in the differentiation of T helper (Th)1 and Th17 cells, respectively. Th1 and Th17 effector cells have been implicated in the pathogenesis of
Externí odkaz:
https://doaj.org/article/bf8dd2078cc148ea9e9bf73ab97c9381
Autor:
Wei Hu, Josbert Metselaar, Li-Hong Ben, Petra D Cravens, Mahendra P Singh, Elliot M Frohman, Todd N Eagar, Michael K Racke, Bernd C Kieseier, Olaf Stüve
Publikováno v:
PLoS ONE, Vol 4, Iss 1, p e4151 (2009)
Minocycline is an oral tetracycline derivative with good bioavailability in the central nervous system (CNS). Minocycline, a potent inhibitor of matrix metalloproteinase (MMP)-9, attenuates disease activity in experimental autoimmune encephalomyeliti
Externí odkaz:
https://doaj.org/article/10b2eb9295b549ceaada9a6ad5a4749d
Autor:
Navid, Manouchehri, Rehana Z, Hussain, Petra D, Cravens, Ekaterina, Esaulova, Maxim N, Artyomov, Brian T, Edelson, Gregory F, Wu, Anne H, Cross, Richard, Doelger, Nicolas, Loof, Todd N, Eagar, Thomas G, Forsthuber, Laurent, Calvier, Joachim, Herz, Olaf, Stüve
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The bone marrow-derived CD11c+CD88+CD317+ myeloid cells within the central nervous system are associated with clinical experimental autoimmune encephalomyelitis. Transcriptional analyses identify ITGAX- (CD11c), C5AR1- (CD88), and BST2-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::49968c3c54e58bfee05bafc263367b55
https://pubmed.ncbi.nlm.nih.gov/33785592
https://pubmed.ncbi.nlm.nih.gov/33785592
Autor:
Olaf Stüve, Gregory F. Wu, Navid Manouchehri, Brian T. Edelson, Nicolas Loof, Joachim Herz, Ekaterina Esaulova, Anne H. Cross, Petra D. Cravens, Thomas G. Forsthuber, Maxim N. Artyomov, Rehana Z. Hussain, Laurent Calvier, Todd N. Eagar, Richard Doelger
Publikováno v:
Proceedings of the National Academy of Sciences. 118
Natalizumab, a humanized monoclonal antibody (mAb) against α4-integrin, reduces the number of dendritic cells (DC) in cerebral perivascular spaces in multiple sclerosis (MS). Selective deletion of α4-integrin in CD11c+ cells should curtail their mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c6e117b1e9a65f2874bf4c5f579a4ff
https://doi.org/10.1073/pnas.2014492118
https://doi.org/10.1073/pnas.2014492118
Autor:
Petra D. Cravens, Todd N. Eagar, Richard Doelger, Joachim Herz, Brian T. Edelson, Rehana Z. Hussain, Laurent Calvier, Olaf Stüve, Anne H. Cross, Nicolas Loof, Thomas G. Forsthuber, Gregory F. Wu, Navid Manouchehri
BackgroundNatalizumab, a humanized monoclonal antibody (mAb) against α4-integrin, reduces the number of dendritic cells (DC) in cerebral perivascular spaces in multiple sclerosis (MS). Selective deletion of α4-integrin in CD11c+ cells should curtai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::107419c69d9e0e8e094eca323719ba63
https://doi.org/10.1101/2020.06.10.144956
https://doi.org/10.1101/2020.06.10.144956
Autor:
Navid, Manouchehri, Rehana Z, Hussain, Petra D, Cravens, Richard, Doelger, Benjamin M, Greenberg, Darin T, Okuda, Thomas G, Forsthuber, Todd N, Eagar, Olaf, Stüve
Publikováno v:
Journal of neuroimmunology. 344
The Cre-lox system is a non-dynamic method of gene modification and characterization. Promoters thought to be relatively cell-specific are utilized for generation of cell-lineage-specific gene modifications.CD11c.CreA significant reduction of α4-int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c00ae8650c59c6a5c1a157d6efeb2f4e
https://pubmed.ncbi.nlm.nih.gov/32335319
https://pubmed.ncbi.nlm.nih.gov/32335319
Autor:
Nicolas Loof, Olaf Stüve, Darin T. Okuda, Peter T. Tsai, Emily Herndon, Brianne Dentel, Petra D. Cravens, Rehana Z. Hussain, Richard Doelger, Michael K. Racke
Publikováno v:
Annals of Clinical and Translational Neurology. 5:1543-1561
Objective Natalizumab blocks α4-integrin-mediated leukocyte migration into the central nervous system (CNS). It diminishes disease activity in multiple sclerosis (MS), but carries a high risk of progressive multifocal encephalopathy (PML), an opport
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d2553cd1b59cdc9d3efd539b365767d
https://doi.org/10.1002/acn3.664
https://doi.org/10.1002/acn3.664
Autor:
Teja Celhar, Anna-Marie Fairhurst, Anne B. Satterthwaite, Laurie S. Davis, Petra D. Cravens, Olga Zharkova
Publikováno v:
Rheumatology (Oxford, England)
SLE is a chronic autoimmune disease caused by perturbations of the immune system. The clinical presentation is heterogeneous, largely because of the multiple genetic and environmental factors that contribute to disease initiation and progression. Ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e760ecaf18f1117d799ebb222395de
http://europepmc.org/articles/PMC5410978
http://europepmc.org/articles/PMC5410978
Autor:
Olaf Stüve, Thomas G. Forsthuber, Benjamin Greenberg, Petra D. Cravens, Rehana Z. Hussain, Navid Manouchehri, Darin T. Okuda, Todd N. Eagar, Richard Doelger
Publikováno v:
Journal of Neuroimmunology. 344:577245
Background The Cre-lox system is a non-dynamic method of gene modification and characterization. Promoters thought to be relatively cell-specific are utilized for generation of cell-lineage-specific gene modifications. Methods CD11c.Cre+ITGA4fl/fl mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af5df937f09e821a0377759fbcafd210
https://doi.org/10.1016/j.jneuroim.2020.577245
https://doi.org/10.1016/j.jneuroim.2020.577245
Autor:
Rehana Z. Hussain, Todd N. Eagar, Richard Doelger, Valerie Granados, William A. Miller-Little, Olaf Stüve, Petra D. Cravens, Darin T. Okuda, Emily Herndon
Publikováno v:
Neurology® Neuroimmunology & Neuroinflammation
ObjectiveThe goal of this study was to investigate the role of CD 19+B cells within the brain and spinal cord during CNS autoimmunity in a peptide-induced, primarily T-cell–mediated experimental autoimmune encephalomyelitis (EAE) model of MS. We hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83aa286482af82048134aa19b22320fe
https://pubmed.ncbi.nlm.nih.gov/31403056
https://pubmed.ncbi.nlm.nih.gov/31403056