Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Petra C. Kienesberger"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Obesity is a state of metabolic dysfunction that can lead to dyslipidemia and impaired glucose homeostasis. Apple polyphenols have been shown to ameliorate dyslipidemia/metabolic dysfunction in humans. The influence of apple (poly)phenols on
Externí odkaz:
https://doaj.org/article/74f41e20e52a4975b33ac5555d1ef099
Autor:
Dipsikha Biswas, Logan Slade, Luke Duffley, Neil Mueller, Khoi Thien Dao, Angella Mercer, Shanmugasundaram Pakkiriswami, Yassine El Hiani, Petra C. Kienesberger, Thomas Pulinilkunnil
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-12 (2021)
Proposed mechanism. A Doxorubicin (DOX) targets the BCAA catabolic pathway in TNBCs, by downregulating BCKDK and augmenting clearance of intracellular BCKAs. B Genetic or pharmacological (high BT2 concentration) inhibition of BCKDK results in increas
Externí odkaz:
https://doaj.org/article/004b3d68105a445d9f322e3d584c6ae8
Autor:
Christie M. Aguiar, Kareem Gawdat, Stephanie Legere, Jean Marshall, Ansar Hassan, Petra C. Kienesberger, Thomas Pulinilkunnil, Mathieu Castonguay, Keith R. Brunt, Jean-Francois Legare
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-14 (2019)
Abstract Background The objectives of the study were to characterize and quantify cellular inflammation and structural remodeling of human atria and correlate findings with molecular markers of inflammation and patient surrogate outcome. Methods Volu
Externí odkaz:
https://doaj.org/article/9c829a9be3d04259b8e79b3e14aaf0df
Autor:
Dipsikha Biswas, Kathleen Tozer, Khoi T. Dao, Lester J. Perez, Angella Mercer, Amy Brown, Intekhab Hossain, Alexandra M. Yip, Christie Aguiar, Hany Motawea, Keith R. Brunt, Jennifer Shea, Jean F. Legare, Ansar Hassan, Petra C. Kienesberger, Thomas Pulinilkunnil
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Background: Predicting relapses of post-operative complications in obese patients who undergo cardiac surgery is significantly complicated by persistent metabolic maladaptation associated with obesity. Despite studies supporting the linkages of incre
Externí odkaz:
https://doaj.org/article/8fa588f2063c4f8f8b9ae2e309709fd0
Autor:
Kenneth D'Souza, Carine Nzirorera, Andrew M. Cowie, Geena P. Varghese, Purvi Trivedi, Thomas O. Eichmann, Dipsikha Biswas, Mohamed Touaibia, Andrew J. Morris, Vassilis Aidinis, Daniel A. Kane, Thomas Pulinilkunnil, Petra C. Kienesberger
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 10, Pp 1805-1817 (2018)
Autotaxin (ATX) is an adipokine that generates the bioactive lipid, lysophosphatidic acid (LPA). ATX-LPA signaling has been implicated in diet-induced obesity and systemic insulin resistance. However, it remains unclear whether the ATX-LPA pathway in
Externí odkaz:
https://doaj.org/article/a7d0f675a50149038c6e8eb316042478
Autor:
Anu Jose, Petra C. Kienesberger
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 17, p 9575 (2021)
Besides serving as a structural membrane component and intermediate of the glycerolipid metabolism, lysophosphatidic acid (LPA) has a prominent role as a signaling molecule through its binding to LPA receptors at the cell surface. Extracellular LPA i
Externí odkaz:
https://doaj.org/article/c43ed42c1404437c93872758db04aa0a
Autor:
Lester J. Perez, Liliam Rios, Purvi Trivedi, Kenneth D’Souza, Andrew Cowie, Carine Nzirorera, Duncan Webster, Keith Brunt, Jean-Francois Legare, Ansar Hassan, Petra C. Kienesberger, Thomas Pulinilkunnil
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract The global incidence of obesity has led to an increasing need for understanding the molecular mechanisms that drive this epidemic and its comorbidities. Quantitative real-time RT-PCR (RT-qPCR) is the most reliable and widely used method for
Externí odkaz:
https://doaj.org/article/a44ca9d6535b468986ac3dcbda46d949
Autor:
Kenneth D’Souza, Angella Mercer, Hannah Mawhinney, Thomas Pulinilkunnil, Chibuike C. Udenigwe, Petra C. Kienesberger
Publikováno v:
Nutrients, Vol 12, Iss 2, p 425 (2020)
Deregulation of lipid metabolism and insulin function in muscle and adipose tissue are hallmarks of systemic insulin resistance, which can progress to type 2 diabetes. While previous studies suggested that milk proteins influence systemic glucose hom
Externí odkaz:
https://doaj.org/article/f60c96ee19224f278ef086327e33f950
Relationship of glucose and oleate metabolism to cardiac function in lipin-1 deficient (fld) mice[S]
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 1, Pp 105-118 (2012)
Lipin-1 is the major phosphatidate phosphatase (PAP) in the heart and a transcriptional coactivator that regulates fatty acid (FA) oxidation in the liver. As the control of FA metabolism is essential for maintaining cardiac function, we investigated
Externí odkaz:
https://doaj.org/article/f9de88e5029743a6af598391eb7551ae
Autor:
Gabriele Schoiswohl, Martina Schweiger, Renate Schreiber, Gregor Gorkiewicz, Karina Preiss-Landl, Ulrike Taschler, Kathrin A. Zierler, Franz P.W. Radner, Thomas O. Eichmann, Petra C. Kienesberger, Sandra Eder, Achim Lass, Guenter Haemmerle, Thomas J. Alsted, Bente Kiens, Gerald Hoefler, Rudolf Zechner, Robert Zimmermann
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 3, Pp 490-499 (2010)
FAs are mobilized from triglyceride (TG) stores during exercise to supply the working muscle with energy. Mice deficient for adipose triglyceride lipase (ATGL-ko) exhibit defective lipolysis and accumulate TG in adipose tissue and muscle, suggesting
Externí odkaz:
https://doaj.org/article/e6767bddb33b4e44b985ee5aa3151637