Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Petra C Kienesberger"'
Autor:
Amy Brown, Intekhab Hossain, Lester J Perez, Carine Nzirorera, Kathleen Tozer, Kenneth D'Souza, Purvi C Trivedi, Christie Aguiar, Alexandra M Yip, Jennifer Shea, Keith R Brunt, Jean-Francois Legare, Ansar Hassan, Thomas Pulinilkunnil, Petra C Kienesberger
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189402 (2017)
Lysophosphatidic acid (LPA) receptor signaling has been implicated in cardiovascular and obesity-related metabolic disease. However, the distribution and regulation of LPA receptors in the myocardium and adipose tissue remain unclear.This study aimed
Externí odkaz:
https://doaj.org/article/45e0e150667b41e18bc7376440a54e01
Autor:
Ross A Breckenridge, Izabela Piotrowska, Keat-Eng Ng, Timothy J Ragan, James A West, Surendra Kotecha, Norma Towers, Michael Bennett, Petra C Kienesberger, Ryszard T Smolenski, Hillary K Siddall, John L Offer, Mihaela M Mocanu, Derek M Yelon, Jason R B Dyck, Jules L Griffin, Andrey Y Abramov, Alex P Gould, Timothy J Mohun
Publikováno v:
PLoS Biology, Vol 11, Iss 9, p e1001666 (2013)
Cardiomyocytes are vulnerable to hypoxia in the adult, but adapted to hypoxia in utero. Current understanding of endogenous cardiac oxygen sensing pathways is limited. Myocardial oxygen consumption is determined by regulation of energy metabolism, wh
Externí odkaz:
https://doaj.org/article/c94bc252bb4048fdb56691e64de2627d
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Obesity is a state of metabolic dysfunction that can lead to dyslipidemia and impaired glucose homeostasis. Apple polyphenols have been shown to ameliorate dyslipidemia/metabolic dysfunction in humans. The influence of apple (poly)phenols on
Externí odkaz:
https://doaj.org/article/74f41e20e52a4975b33ac5555d1ef099
Autor:
Angkoon Phinyomark, Keith R. Brunt, Petra C. Kienesberger, Jean-Francois Légaré, Kevin Russell, Erik Scheme, Nagaprasad Puvvada, Ansar Hassan, Thomas Pulinilkunnil, Elizabeth Zed, Alli Murugesan, Stacy Grieve, Tony Reiman
Publikováno v:
Nanomedicine. 16:2175-2188
Aim: Monitoring minimal residual disease remains a challenge to the effective medical management of hematological malignancies; yet surface-enhanced Raman spectroscopy (SERS) has emerged as a potential clinical tool to do so. Materials & methods: We
Publikováno v:
The Journal of biological chemistry. 298(12)
Triple-negative breast cancer (TNBC) poses significant challenges for treatment given the lack of targeted therapies and increased probability of relapse. It is pertinent to identify vulnerabilities in TNBC and develop newer treatments. Our prior res
Autor:
Petra C. Kienesberger, Kareem Gawdat, Jean S. Marshall, Stephanie Legere, Jean-Francois Légaré, Keith R. Brunt, Thomas Pulinilkunnil, Christie Aguiar, Mathieu Castonguay, Ansar Hassan
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-14 (2019)
Journal of Translational Medicine
Journal of Translational Medicine
Background The objectives of the study were to characterize and quantify cellular inflammation and structural remodeling of human atria and correlate findings with molecular markers of inflammation and patient surrogate outcome. Methods Voluntary par
Autor:
Dipsikha Biswas, Angella Mercer, Neil Mueller, Petra C. Kienesberger, Thomas Pulinilkunnil, Yassine El Hiani, Luke Duffley, Shanmugasundaram Pakkiriswami, Khoi Thien Dao, Logan Slade
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-12 (2021)
Cell Death Discovery
Cell Death Discovery
Triple-negative breast cancers (TNBCs) are characterized by poor survival, prognosis, and gradual resistance to cytotoxic chemotherapeutics, like doxorubicin (DOX). The clinical utility of DOX is limited by its cardiotoxic and chemoresistant effects
Autor:
Angella Mercer, Chibuike C. Udenigwe, Thomas Pulinilkunnil, Petra C. Kienesberger, Caleb Acquah, Kenneth D'Souza, Yadab Paudel
Publikováno v:
Foodfunction. 12(8)
Consumption of milk-derived whey proteins has been demonstrated to have insulin-sensitizing effects in mice and humans, in part through the generation of bioactive whey peptides. While whey peptides can prevent insulin resistance in vitro, it is uncl
Autor:
Thomas Pulinilkunnil, Vassilis Aidinis, Dipsikha Biswas, Geena Paramel Varghese, Petra C. Kienesberger, Daniel A. Kane, Andrew J. Morris, Thomas O. Eichmann, Carine Nzirorera, Kenneth D'Souza, Purvi C. Trivedi, Andrew M. Cowie, Mohamed Touaibia
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 10, Pp 1805-1817 (2018)
Autotaxin (ATX) is an adipokine that generates the bioactive lipid, lysophosphatidic acid (LPA). ATX-LPA signaling has been implicated in diet-induced obesity and systemic insulin resistance. However, it remains unclear whether the ATX-LPA pathway in
Autor:
Chibuike C. Udenigwe, Esther Yi, Kenneth D'Souza, Roghayeh Amini Sarteshnizi, Petra C. Kienesberger
The prevalence of diabetes mellitus, a chronic disease characterized by marked alterations in energy homeostasis, is increasing at rapid rates globally, fuelled in part by the obesity epidemic. Although diabetes can be managed using multi-drug therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de1bb144c03ad27f840ef41d2c08b415
https://doi.org/10.1039/9781839163425-00311
https://doi.org/10.1039/9781839163425-00311